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Serum ferritin levels predict incident non-alcoholic fatty liver disease in healthy Korean men.
Metabolism. 2012 Aug; 61(8):1182-8.M

Abstract

Little research has been done to examine the temporal relationship between serum ferritin and the development of nonalcoholic fatty liver disease. The aim of this study was to examine whether serum ferritin levels predict incident fatty liver in non-diabetic men. The study cohort comprised 2410 healthy Korean male who were aged 30 to 59years old with no evidence of ultrasonographically detectable fatty liver (USFL) at baseline. Alcohol intake was assessed with a self-reported questionnaire. At each visit, biochemical and anthropometric measurements and abdominal ultrasonography were done. Cox proportional hazard models were used to calculate the adjusted hazard ratios in separate models for USFL. During 7545.9 person-years of follow-up, 586 participants developed USFL. The hazard ratio (95% confidence interval) for incident USFL comparing the highest quartile of serum ferritin level to the lowest quartile was 1.54 (1.21-1.94) after adjusting for age, body mass index, smoking, alcohol intake, and exercise. That association remained significant after further adjustment for cardiovascular risk factors and in time-dependent models. The association between serum ferritin and incident USFL was still significant in the non-overweight group or the no current smoker group. Serum ferritin level was an independent risk factor of incident fatty liver detected by ultrasonography even in non-obese, healthy Korean men. Increased serum ferritin levels appear to be an early predictor for incident fatty liver.

Authors+Show Affiliations

Health Screening Center, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22386931

Citation

Kim, Chan-Won, et al. "Serum Ferritin Levels Predict Incident Non-alcoholic Fatty Liver Disease in Healthy Korean Men." Metabolism: Clinical and Experimental, vol. 61, no. 8, 2012, pp. 1182-8.
Kim CW, Chang Y, Sung E, et al. Serum ferritin levels predict incident non-alcoholic fatty liver disease in healthy Korean men. Metabolism. 2012;61(8):1182-8.
Kim, C. W., Chang, Y., Sung, E., Shin, H., & Ryu, S. (2012). Serum ferritin levels predict incident non-alcoholic fatty liver disease in healthy Korean men. Metabolism: Clinical and Experimental, 61(8), 1182-8. https://doi.org/10.1016/j.metabol.2012.01.007
Kim CW, et al. Serum Ferritin Levels Predict Incident Non-alcoholic Fatty Liver Disease in Healthy Korean Men. Metabolism. 2012;61(8):1182-8. PubMed PMID: 22386931.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum ferritin levels predict incident non-alcoholic fatty liver disease in healthy Korean men. AU - Kim,Chan-Won, AU - Chang,Yoosoo, AU - Sung,Eunju, AU - Shin,Hocheol, AU - Ryu,Seungho, Y1 - 2012/03/03/ PY - 2011/09/20/received PY - 2012/01/05/revised PY - 2012/01/06/accepted PY - 2012/3/6/entrez PY - 2012/3/6/pubmed PY - 2012/10/2/medline SP - 1182 EP - 8 JF - Metabolism: clinical and experimental JO - Metabolism VL - 61 IS - 8 N2 - Little research has been done to examine the temporal relationship between serum ferritin and the development of nonalcoholic fatty liver disease. The aim of this study was to examine whether serum ferritin levels predict incident fatty liver in non-diabetic men. The study cohort comprised 2410 healthy Korean male who were aged 30 to 59years old with no evidence of ultrasonographically detectable fatty liver (USFL) at baseline. Alcohol intake was assessed with a self-reported questionnaire. At each visit, biochemical and anthropometric measurements and abdominal ultrasonography were done. Cox proportional hazard models were used to calculate the adjusted hazard ratios in separate models for USFL. During 7545.9 person-years of follow-up, 586 participants developed USFL. The hazard ratio (95% confidence interval) for incident USFL comparing the highest quartile of serum ferritin level to the lowest quartile was 1.54 (1.21-1.94) after adjusting for age, body mass index, smoking, alcohol intake, and exercise. That association remained significant after further adjustment for cardiovascular risk factors and in time-dependent models. The association between serum ferritin and incident USFL was still significant in the non-overweight group or the no current smoker group. Serum ferritin level was an independent risk factor of incident fatty liver detected by ultrasonography even in non-obese, healthy Korean men. Increased serum ferritin levels appear to be an early predictor for incident fatty liver. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/22386931/Serum_ferritin_levels_predict_incident_non_alcoholic_fatty_liver_disease_in_healthy_Korean_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(12)00035-2 DB - PRIME DP - Unbound Medicine ER -