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Deficiency of serum concentration of 25-hydroxyvitamin D in psoriatic patients: a case-control study.

Abstract

BACKGROUND

Some autoimmune conditions have been associated with reduced vitamin D levels, including systemic lupus erythematosus, rheumatoid arthritis, diabetes mellitus, and multiple sclerosis.

OBJECTIVE

The main objective of this study was to analyze the 25-hydroxyvitamin D (OHD) status of patients with psoriasis in comparison with control subjects without this disease.

METHODS

This case-control study included 86 patients (43 with psoriasis and 43 age- and sex-matched control subjects) from the outpatient clinic of our hospital dermatology department in Granada, Spain. All patients and control subjects were studied during one 4-week period to avoid seasonal variations in vitamin D levels.

RESULTS

Serum 25-OHD levels were significantly lower in psoriatic patients than in control subjects even after adjusting for confounding factors in a multivariate analysis (odds ratio 2.89, 95% confidence interval 1.02-7.64, P < .03 for vitamin D insufficiency). Low 25-OHD levels were negatively associated with C-reactive protein (inflammatory activation marker) and body mass index in multiple linear regression analysis. Psoriatic patients with body mass index greater than or equal to 27 kg/m(2) had a higher risk of 25-OHD insufficiency (sensitivity of 82.3% and specificity of 51.7%).

LIMITATIONS

Further studies with larger numbers of patients are required to analyze the pathogenic mechanisms underlying the relationship between 25-OHD deficiency and psoriasis.

CONCLUSIONS

The 25-OHD values are significantly lower in psoriatic patients than in control subjects. Low 25-OHD levels are negatively associated with C-reactive protein, an inflammatory activation marker, and with obesity. Psoriatic patients with a body mass index of 27 or more are likely to have vitamin D insufficiency.

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  • Authors+Show Affiliations

    ,

    Dermatology Department, San Cecilio University Hospital, Granada, Spain.

    , , ,

    Source

    MeSH

    Adult
    Autoimmunity
    Body Mass Index
    C-Reactive Protein
    Case-Control Studies
    Female
    Humans
    Hydroxycholecalciferols
    Logistic Models
    Male
    Multivariate Analysis
    Obesity
    Psoriasis
    ROC Curve
    Sensitivity and Specificity
    Vitamin D Deficiency

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22387034

    Citation

    Orgaz-Molina, Jacinto, et al. "Deficiency of Serum Concentration of 25-hydroxyvitamin D in Psoriatic Patients: a Case-control Study." Journal of the American Academy of Dermatology, vol. 67, no. 5, 2012, pp. 931-8.
    Orgaz-Molina J, Buendía-Eisman A, Arrabal-Polo MA, et al. Deficiency of serum concentration of 25-hydroxyvitamin D in psoriatic patients: a case-control study. J Am Acad Dermatol. 2012;67(5):931-8.
    Orgaz-Molina, J., Buendía-Eisman, A., Arrabal-Polo, M. A., Ruiz, J. C., & Arias-Santiago, S. (2012). Deficiency of serum concentration of 25-hydroxyvitamin D in psoriatic patients: a case-control study. Journal of the American Academy of Dermatology, 67(5), pp. 931-8. doi:10.1016/j.jaad.2012.01.040.
    Orgaz-Molina J, et al. Deficiency of Serum Concentration of 25-hydroxyvitamin D in Psoriatic Patients: a Case-control Study. J Am Acad Dermatol. 2012;67(5):931-8. PubMed PMID: 22387034.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Deficiency of serum concentration of 25-hydroxyvitamin D in psoriatic patients: a case-control study. AU - Orgaz-Molina,Jacinto, AU - Buendía-Eisman,Agustín, AU - Arrabal-Polo,Miguel A, AU - Ruiz,José Carlos, AU - Arias-Santiago,Salvador, Y1 - 2012/03/02/ PY - 2011/08/05/received PY - 2012/01/06/revised PY - 2012/01/13/accepted PY - 2012/3/6/entrez PY - 2012/3/6/pubmed PY - 2013/1/18/medline SP - 931 EP - 8 JF - Journal of the American Academy of Dermatology JO - J. Am. Acad. Dermatol. VL - 67 IS - 5 N2 - BACKGROUND: Some autoimmune conditions have been associated with reduced vitamin D levels, including systemic lupus erythematosus, rheumatoid arthritis, diabetes mellitus, and multiple sclerosis. OBJECTIVE: The main objective of this study was to analyze the 25-hydroxyvitamin D (OHD) status of patients with psoriasis in comparison with control subjects without this disease. METHODS: This case-control study included 86 patients (43 with psoriasis and 43 age- and sex-matched control subjects) from the outpatient clinic of our hospital dermatology department in Granada, Spain. All patients and control subjects were studied during one 4-week period to avoid seasonal variations in vitamin D levels. RESULTS: Serum 25-OHD levels were significantly lower in psoriatic patients than in control subjects even after adjusting for confounding factors in a multivariate analysis (odds ratio 2.89, 95% confidence interval 1.02-7.64, P < .03 for vitamin D insufficiency). Low 25-OHD levels were negatively associated with C-reactive protein (inflammatory activation marker) and body mass index in multiple linear regression analysis. Psoriatic patients with body mass index greater than or equal to 27 kg/m(2) had a higher risk of 25-OHD insufficiency (sensitivity of 82.3% and specificity of 51.7%). LIMITATIONS: Further studies with larger numbers of patients are required to analyze the pathogenic mechanisms underlying the relationship between 25-OHD deficiency and psoriasis. CONCLUSIONS: The 25-OHD values are significantly lower in psoriatic patients than in control subjects. Low 25-OHD levels are negatively associated with C-reactive protein, an inflammatory activation marker, and with obesity. Psoriatic patients with a body mass index of 27 or more are likely to have vitamin D insufficiency. SN - 1097-6787 UR - https://www.unboundmedicine.com/medline/citation/22387034/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0190-9622(12)00142-9 DB - PRIME DP - Unbound Medicine ER -