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Deficiency of serum concentration of 25-hydroxyvitamin D in psoriatic patients: a case-control study.
J Am Acad Dermatol 2012; 67(5):931-8JA

Abstract

BACKGROUND

Some autoimmune conditions have been associated with reduced vitamin D levels, including systemic lupus erythematosus, rheumatoid arthritis, diabetes mellitus, and multiple sclerosis.

OBJECTIVE

The main objective of this study was to analyze the 25-hydroxyvitamin D (OHD) status of patients with psoriasis in comparison with control subjects without this disease.

METHODS

This case-control study included 86 patients (43 with psoriasis and 43 age- and sex-matched control subjects) from the outpatient clinic of our hospital dermatology department in Granada, Spain. All patients and control subjects were studied during one 4-week period to avoid seasonal variations in vitamin D levels.

RESULTS

Serum 25-OHD levels were significantly lower in psoriatic patients than in control subjects even after adjusting for confounding factors in a multivariate analysis (odds ratio 2.89, 95% confidence interval 1.02-7.64, P < .03 for vitamin D insufficiency). Low 25-OHD levels were negatively associated with C-reactive protein (inflammatory activation marker) and body mass index in multiple linear regression analysis. Psoriatic patients with body mass index greater than or equal to 27 kg/m(2) had a higher risk of 25-OHD insufficiency (sensitivity of 82.3% and specificity of 51.7%).

LIMITATIONS

Further studies with larger numbers of patients are required to analyze the pathogenic mechanisms underlying the relationship between 25-OHD deficiency and psoriasis.

CONCLUSIONS

The 25-OHD values are significantly lower in psoriatic patients than in control subjects. Low 25-OHD levels are negatively associated with C-reactive protein, an inflammatory activation marker, and with obesity. Psoriatic patients with a body mass index of 27 or more are likely to have vitamin D insufficiency.

Authors+Show Affiliations

Dermatology Department, San Cecilio University Hospital, Granada, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22387034

Citation

Orgaz-Molina, Jacinto, et al. "Deficiency of Serum Concentration of 25-hydroxyvitamin D in Psoriatic Patients: a Case-control Study." Journal of the American Academy of Dermatology, vol. 67, no. 5, 2012, pp. 931-8.
Orgaz-Molina J, Buendía-Eisman A, Arrabal-Polo MA, et al. Deficiency of serum concentration of 25-hydroxyvitamin D in psoriatic patients: a case-control study. J Am Acad Dermatol. 2012;67(5):931-8.
Orgaz-Molina, J., Buendía-Eisman, A., Arrabal-Polo, M. A., Ruiz, J. C., & Arias-Santiago, S. (2012). Deficiency of serum concentration of 25-hydroxyvitamin D in psoriatic patients: a case-control study. Journal of the American Academy of Dermatology, 67(5), pp. 931-8. doi:10.1016/j.jaad.2012.01.040.
Orgaz-Molina J, et al. Deficiency of Serum Concentration of 25-hydroxyvitamin D in Psoriatic Patients: a Case-control Study. J Am Acad Dermatol. 2012;67(5):931-8. PubMed PMID: 22387034.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Deficiency of serum concentration of 25-hydroxyvitamin D in psoriatic patients: a case-control study. AU - Orgaz-Molina,Jacinto, AU - Buendía-Eisman,Agustín, AU - Arrabal-Polo,Miguel A, AU - Ruiz,José Carlos, AU - Arias-Santiago,Salvador, Y1 - 2012/03/02/ PY - 2011/08/05/received PY - 2012/01/06/revised PY - 2012/01/13/accepted PY - 2012/3/6/entrez PY - 2012/3/6/pubmed PY - 2013/1/18/medline SP - 931 EP - 8 JF - Journal of the American Academy of Dermatology JO - J. Am. Acad. Dermatol. VL - 67 IS - 5 N2 - BACKGROUND: Some autoimmune conditions have been associated with reduced vitamin D levels, including systemic lupus erythematosus, rheumatoid arthritis, diabetes mellitus, and multiple sclerosis. OBJECTIVE: The main objective of this study was to analyze the 25-hydroxyvitamin D (OHD) status of patients with psoriasis in comparison with control subjects without this disease. METHODS: This case-control study included 86 patients (43 with psoriasis and 43 age- and sex-matched control subjects) from the outpatient clinic of our hospital dermatology department in Granada, Spain. All patients and control subjects were studied during one 4-week period to avoid seasonal variations in vitamin D levels. RESULTS: Serum 25-OHD levels were significantly lower in psoriatic patients than in control subjects even after adjusting for confounding factors in a multivariate analysis (odds ratio 2.89, 95% confidence interval 1.02-7.64, P < .03 for vitamin D insufficiency). Low 25-OHD levels were negatively associated with C-reactive protein (inflammatory activation marker) and body mass index in multiple linear regression analysis. Psoriatic patients with body mass index greater than or equal to 27 kg/m(2) had a higher risk of 25-OHD insufficiency (sensitivity of 82.3% and specificity of 51.7%). LIMITATIONS: Further studies with larger numbers of patients are required to analyze the pathogenic mechanisms underlying the relationship between 25-OHD deficiency and psoriasis. CONCLUSIONS: The 25-OHD values are significantly lower in psoriatic patients than in control subjects. Low 25-OHD levels are negatively associated with C-reactive protein, an inflammatory activation marker, and with obesity. Psoriatic patients with a body mass index of 27 or more are likely to have vitamin D insufficiency. SN - 1097-6787 UR - https://www.unboundmedicine.com/medline/citation/22387034/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0190-9622(12)00142-9 DB - PRIME DP - Unbound Medicine ER -