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Antiinflammatory, analgesic and antioxidant activities of Cyathula prostrata (Linn.) Blume (Amaranthaceae).
J Ethnopharmacol. 2012 May 07; 141(1):282-9.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Cyathula prostrata (Linn) Blume (Amaranthaceae) is an annual herb widely used traditionally in the treatment of various inflammatory and pain related health disorders in Nigeria. The aim of this study is to evaluate the anti-inflammatory, analgesic and antioxidant activities of the methanolic extract of Cyathula prostrata (Linn) Blume.

MATERIALS AND METHODS

The anti-inflammatory (phorbol 12-myristate 13-acetate (PMA)-induced reactive oxygen species (ROS), lipopolysaccharide (LPS) induced nitric oxide production in U937 macrophages, LPS-induced COX-2 expression, carrageenan-induced rat paw oedema, arachidonic acid-induced ear oedema and xylene-induced ear oedema), analgesic (acetic acid-induced writhing and hot plate tests) and antioxidant activities (DPPH [1,1-diphenyl-2-picrylhydrazyl] and lipid peroxidation assays) activities of the plant extract were investigated.

RESULTS

The methanolic extract of Cyathula prostrata did not show inhibitory activity in the in vitro PMA-induced reactive oxygen species, LPS-induced nitric oxide production and LPS-induced COX-2 expression assays. In the in vivo anti-inflammatory assays, the extract (50, 100 and 200mg/kg) showed a significant (P<0.05) dose-dependent inhibition in the carrageenan, arachidonic acid and xylene-induced tests. Cyathula prostrata produced a significant (P<0.05, 0.001) dose-dependent inhibition in the acetic acid and hot plate analgesic tests respectively. The plant extract did not exhibit any antioxidant activity in the DPPH and lipid peroxidation assays.

CONCLUSION

The results suggest that the methanolic extract of Cyathula prostrata possesses anti-inflammatory and analgesic activities and this authenticates the use of the plant in the traditional treatment of ailments associated with inflammation and pain.

Authors+Show Affiliations

Department of Pharmacognosy, Faculty of Pharmacy, University of Lagos, College of Medicine Campus, Idi-Araba, Lagos, Nigeria.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22387161

Citation

Ibrahim, Bolanle, et al. "Antiinflammatory, Analgesic and Antioxidant Activities of Cyathula Prostrata (Linn.) Blume (Amaranthaceae)." Journal of Ethnopharmacology, vol. 141, no. 1, 2012, pp. 282-9.
Ibrahim B, Sowemimo A, van Rooyen A, et al. Antiinflammatory, analgesic and antioxidant activities of Cyathula prostrata (Linn.) Blume (Amaranthaceae). J Ethnopharmacol. 2012;141(1):282-9.
Ibrahim, B., Sowemimo, A., van Rooyen, A., & Van de Venter, M. (2012). Antiinflammatory, analgesic and antioxidant activities of Cyathula prostrata (Linn.) Blume (Amaranthaceae). Journal of Ethnopharmacology, 141(1), 282-9. https://doi.org/10.1016/j.jep.2012.02.032
Ibrahim B, et al. Antiinflammatory, Analgesic and Antioxidant Activities of Cyathula Prostrata (Linn.) Blume (Amaranthaceae). J Ethnopharmacol. 2012 May 7;141(1):282-9. PubMed PMID: 22387161.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiinflammatory, analgesic and antioxidant activities of Cyathula prostrata (Linn.) Blume (Amaranthaceae). AU - Ibrahim,Bolanle, AU - Sowemimo,Abimbola, AU - van Rooyen,Anzel, AU - Van de Venter,Maryna, Y1 - 2012/03/01/ PY - 2011/11/08/received PY - 2012/02/13/revised PY - 2012/02/14/accepted PY - 2012/3/6/entrez PY - 2012/3/6/pubmed PY - 2012/8/11/medline SP - 282 EP - 9 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 141 IS - 1 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Cyathula prostrata (Linn) Blume (Amaranthaceae) is an annual herb widely used traditionally in the treatment of various inflammatory and pain related health disorders in Nigeria. The aim of this study is to evaluate the anti-inflammatory, analgesic and antioxidant activities of the methanolic extract of Cyathula prostrata (Linn) Blume. MATERIALS AND METHODS: The anti-inflammatory (phorbol 12-myristate 13-acetate (PMA)-induced reactive oxygen species (ROS), lipopolysaccharide (LPS) induced nitric oxide production in U937 macrophages, LPS-induced COX-2 expression, carrageenan-induced rat paw oedema, arachidonic acid-induced ear oedema and xylene-induced ear oedema), analgesic (acetic acid-induced writhing and hot plate tests) and antioxidant activities (DPPH [1,1-diphenyl-2-picrylhydrazyl] and lipid peroxidation assays) activities of the plant extract were investigated. RESULTS: The methanolic extract of Cyathula prostrata did not show inhibitory activity in the in vitro PMA-induced reactive oxygen species, LPS-induced nitric oxide production and LPS-induced COX-2 expression assays. In the in vivo anti-inflammatory assays, the extract (50, 100 and 200mg/kg) showed a significant (P<0.05) dose-dependent inhibition in the carrageenan, arachidonic acid and xylene-induced tests. Cyathula prostrata produced a significant (P<0.05, 0.001) dose-dependent inhibition in the acetic acid and hot plate analgesic tests respectively. The plant extract did not exhibit any antioxidant activity in the DPPH and lipid peroxidation assays. CONCLUSION: The results suggest that the methanolic extract of Cyathula prostrata possesses anti-inflammatory and analgesic activities and this authenticates the use of the plant in the traditional treatment of ailments associated with inflammation and pain. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/22387161/Antiinflammatory_analgesic_and_antioxidant_activities_of_Cyathula_prostrata__Linn___Blume__Amaranthaceae__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(12)00117-1 DB - PRIME DP - Unbound Medicine ER -