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[Neurologic paraneoplastic syndrome with anti-CV2/CRMP5 antibodies revealing a small cell lung cancer. Effectiveness of the lung cancer treatment].
Rev Neurol (Paris). 2012 Apr; 168(4):371-4.RN

Abstract

INTRODUCTION

Paraneoplastic neurological syndrome associated with anti-CV2/CRMP5 antibodies are rare. Various clinical manifestations can occur, cerebellar ataxia, polyneuropathy, optic neuritis with NORB or uveitis. Small cell lung carcinoma is generally responsible.

CASE REPORT

We report the case of a 64-year-old man who developed visual symptoms with papilledema, cerebellar signs, polyneuropathy confirmed with a neurophysiological studies. Anti-CV2/CRMP5 antibodies were present. A small cell lung carcinoma was responsible for this paraneoplastic syndrome revealing the cancer. The paraneoplastic syndrome improved with radio chemotherapy of the cancer alone.

CONCLUSION

A paraneoplastic neurological syndrome must be evoked in case of an atypic neurological syndrome. This diagnostic can be confirmed by the presence of anti-neuronal antibodies. In this case, a small cells cancer of the lung must be research.

Authors+Show Affiliations

Service de pneumologie, hôpital Tenon, 4, rue de la Chine, 75970 Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

fre

PubMed ID

22387203

Citation

Rosencher, L, et al. "[Neurologic Paraneoplastic Syndrome With anti-CV2/CRMP5 Antibodies Revealing a Small Cell Lung Cancer. Effectiveness of the Lung Cancer Treatment]." Revue Neurologique, vol. 168, no. 4, 2012, pp. 371-4.
Rosencher L, Maisonobe T, Lavole A, et al. [Neurologic paraneoplastic syndrome with anti-CV2/CRMP5 antibodies revealing a small cell lung cancer. Effectiveness of the lung cancer treatment]. Rev Neurol (Paris). 2012;168(4):371-4.
Rosencher, L., Maisonobe, T., Lavole, A., Milleron, B., & Ferroir, J. P. (2012). [Neurologic paraneoplastic syndrome with anti-CV2/CRMP5 antibodies revealing a small cell lung cancer. Effectiveness of the lung cancer treatment]. Revue Neurologique, 168(4), 371-4. https://doi.org/10.1016/j.neurol.2011.07.016
Rosencher L, et al. [Neurologic Paraneoplastic Syndrome With anti-CV2/CRMP5 Antibodies Revealing a Small Cell Lung Cancer. Effectiveness of the Lung Cancer Treatment]. Rev Neurol (Paris). 2012;168(4):371-4. PubMed PMID: 22387203.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Neurologic paraneoplastic syndrome with anti-CV2/CRMP5 antibodies revealing a small cell lung cancer. Effectiveness of the lung cancer treatment]. AU - Rosencher,L, AU - Maisonobe,T, AU - Lavole,A, AU - Milleron,B, AU - Ferroir,J-P, Y1 - 2012/03/03/ PY - 2011/02/09/received PY - 2011/06/27/revised PY - 2011/07/05/accepted PY - 2012/3/6/entrez PY - 2012/3/6/pubmed PY - 2012/9/6/medline SP - 371 EP - 4 JF - Revue neurologique JO - Rev. Neurol. (Paris) VL - 168 IS - 4 N2 - INTRODUCTION: Paraneoplastic neurological syndrome associated with anti-CV2/CRMP5 antibodies are rare. Various clinical manifestations can occur, cerebellar ataxia, polyneuropathy, optic neuritis with NORB or uveitis. Small cell lung carcinoma is generally responsible. CASE REPORT: We report the case of a 64-year-old man who developed visual symptoms with papilledema, cerebellar signs, polyneuropathy confirmed with a neurophysiological studies. Anti-CV2/CRMP5 antibodies were present. A small cell lung carcinoma was responsible for this paraneoplastic syndrome revealing the cancer. The paraneoplastic syndrome improved with radio chemotherapy of the cancer alone. CONCLUSION: A paraneoplastic neurological syndrome must be evoked in case of an atypic neurological syndrome. This diagnostic can be confirmed by the presence of anti-neuronal antibodies. In this case, a small cells cancer of the lung must be research. SN - 0035-3787 UR - https://www.unboundmedicine.com/medline/citation/22387203/[Neurologic_paraneoplastic_syndrome_with_anti_CV2/CRMP5_antibodies_revealing_a_small_cell_lung_cancer__Effectiveness_of_the_lung_cancer_treatment]_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0035-3787(12)00008-2 DB - PRIME DP - Unbound Medicine ER -