Tags

Type your tag names separated by a space and hit enter

Fear conditioning in psychopaths: event-related potentials and peripheral measures.
Biol Psychol. 2012 Apr; 90(1):50-9.BP

Abstract

Aversive pavlovian delay conditioning was investigated in a sample of 11 criminal psychopaths as identified by using the Psychopathy Checklist-Revised and 11 matched healthy controls. A painful electric stimulus served as unconditioned stimulus and neutral faces as conditioned stimuli. Event-related potentials, startle response potentiation, skin conductance response, corrugator activity, and heart rate were assessed, along with valence, arousal, and contingency ratings of the CS and US. Compared to healthy controls, psychopathic subjects failed to differentiate between the CS+/CS- as shown by an absence of a conditioned response in startle potentiation and skin conductance measures. Through use of a fear-eliciting US, these data confirm previous findings of a deficient capacity to form associations between neutral and aversive events in psychopathy that appears unrelated to cognitive deficits and is consistent with hypothesized frontolimbic deficits in the disorder.

Authors+Show Affiliations

Department of Psychosomatic Medicine, University Medicine Charité, Berlin, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22387928

Citation

Rothemund, Yvonne, et al. "Fear Conditioning in Psychopaths: Event-related Potentials and Peripheral Measures." Biological Psychology, vol. 90, no. 1, 2012, pp. 50-9.
Rothemund Y, Ziegler S, Hermann C, et al. Fear conditioning in psychopaths: event-related potentials and peripheral measures. Biol Psychol. 2012;90(1):50-9.
Rothemund, Y., Ziegler, S., Hermann, C., Gruesser, S. M., Foell, J., Patrick, C. J., & Flor, H. (2012). Fear conditioning in psychopaths: event-related potentials and peripheral measures. Biological Psychology, 90(1), 50-9. https://doi.org/10.1016/j.biopsycho.2012.02.011
Rothemund Y, et al. Fear Conditioning in Psychopaths: Event-related Potentials and Peripheral Measures. Biol Psychol. 2012;90(1):50-9. PubMed PMID: 22387928.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fear conditioning in psychopaths: event-related potentials and peripheral measures. AU - Rothemund,Yvonne, AU - Ziegler,Silvio, AU - Hermann,Christiane, AU - Gruesser,Sabine M, AU - Foell,Jens, AU - Patrick,Christopher J, AU - Flor,Herta, Y1 - 2012/02/23/ PY - 2011/09/23/received PY - 2012/02/14/revised PY - 2012/02/15/accepted PY - 2012/3/6/entrez PY - 2012/3/6/pubmed PY - 2012/7/27/medline SP - 50 EP - 9 JF - Biological psychology JO - Biol Psychol VL - 90 IS - 1 N2 - Aversive pavlovian delay conditioning was investigated in a sample of 11 criminal psychopaths as identified by using the Psychopathy Checklist-Revised and 11 matched healthy controls. A painful electric stimulus served as unconditioned stimulus and neutral faces as conditioned stimuli. Event-related potentials, startle response potentiation, skin conductance response, corrugator activity, and heart rate were assessed, along with valence, arousal, and contingency ratings of the CS and US. Compared to healthy controls, psychopathic subjects failed to differentiate between the CS+/CS- as shown by an absence of a conditioned response in startle potentiation and skin conductance measures. Through use of a fear-eliciting US, these data confirm previous findings of a deficient capacity to form associations between neutral and aversive events in psychopathy that appears unrelated to cognitive deficits and is consistent with hypothesized frontolimbic deficits in the disorder. SN - 1873-6246 UR - https://www.unboundmedicine.com/medline/citation/22387928/Fear_conditioning_in_psychopaths:_event_related_potentials_and_peripheral_measures_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0301-0511(12)00033-6 DB - PRIME DP - Unbound Medicine ER -