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Cost effectiveness of strategies to combat breast, cervical, and colorectal cancer in sub-Saharan Africa and South East Asia: mathematical modelling study.
BMJ. 2012 Mar 02; 344:e614.BMJ

Abstract

OBJECTIVE

To determine the costs and health effects of interventions to combat breast, cervical, and colorectal cancers in order to guide resource allocation decisions in developing countries.

SETTING

Two World Health Organization sub-regions of the world: countries in sub-Saharan Africa with very high adult and high child mortality (AfrE); and countries in South East Asia with high adult and high child mortality (SearD).

DESIGN

Cost effectiveness analysis of prevention and treatment strategies for breast, cervical, and colorectal cancer, using mathematical modelling based on a lifetime population model.

DATA SOURCES

Demographic and epidemiological data were taken from the WHO mortality and global burden of disease databases. Estimates of intervention coverage, effectiveness, and resource needs were based on clinical trials, treatment guidelines, and expert opinion. Unit costs were taken from the WHO-CHOICE price database.

MAIN OUTCOME MEASURES

Cost per disability adjusted life year (DALY) averted, expressed in international dollars ($Int) for the year 2005.

RESULTS

In both regions certain interventions in cervical cancer control (screening through cervical smear tests or visual inspection with acetic acid in combination with treatment) and colorectal cancer control (increasing the coverage of treatment interventions) cost <$Int2000 per DALY averted and can be considered highly cost effective. In the sub-Saharan African region screening for colorectal cancer (by colonoscopy at age 50 in combination with treatment) costs $Int2000-6000 per DALY averted and can be considered cost effective. In both regions certain interventions in breast cancer control (treatment of all cancer stages in combination with mammography screening) cost $Int2000-6000 per DALY averted and can also be considered cost effective. Other interventions, such as campaigns to eat more fruit and vegetable or subsidies in colorectal cancer control, are not cost effective according to the criteria defined.

CONCLUSION

Highly cost effective interventions to combat cervical and colorectal cancer are available in the African and Asian sub-regions. In cervical cancer control, these include screening through smear tests or visual inspection in combination with treatment. In colorectal cancer, increasing treatment coverage is highly cost effective (screening through colonoscopy is cost effective in the African sub-region). In breast cancer control, mammography screening in combination with treatment of all stages is cost effective.

Authors+Show Affiliations

Department of Medical Technology Assessment, Ministry of Health, Ben Tbai 2, San Simone, Jerusalem, Israel. gary.ginsberg@moh.health.gov.ilNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22389347

Citation

Ginsberg, Gary M., et al. "Cost Effectiveness of Strategies to Combat Breast, Cervical, and Colorectal Cancer in sub-Saharan Africa and South East Asia: Mathematical Modelling Study." BMJ (Clinical Research Ed.), vol. 344, 2012, pp. e614.
Ginsberg GM, Lauer JA, Zelle S, et al. Cost effectiveness of strategies to combat breast, cervical, and colorectal cancer in sub-Saharan Africa and South East Asia: mathematical modelling study. BMJ. 2012;344:e614.
Ginsberg, G. M., Lauer, J. A., Zelle, S., Baeten, S., & Baltussen, R. (2012). Cost effectiveness of strategies to combat breast, cervical, and colorectal cancer in sub-Saharan Africa and South East Asia: mathematical modelling study. BMJ (Clinical Research Ed.), 344, e614. https://doi.org/10.1136/bmj.e614
Ginsberg GM, et al. Cost Effectiveness of Strategies to Combat Breast, Cervical, and Colorectal Cancer in sub-Saharan Africa and South East Asia: Mathematical Modelling Study. BMJ. 2012 Mar 2;344:e614. PubMed PMID: 22389347.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cost effectiveness of strategies to combat breast, cervical, and colorectal cancer in sub-Saharan Africa and South East Asia: mathematical modelling study. AU - Ginsberg,Gary M, AU - Lauer,Jeremy A, AU - Zelle,Sten, AU - Baeten,Steef, AU - Baltussen,Rob, Y1 - 2012/03/02/ PY - 2012/3/6/entrez PY - 2012/3/6/pubmed PY - 2012/4/24/medline SP - e614 EP - e614 JF - BMJ (Clinical research ed.) JO - BMJ VL - 344 N2 - OBJECTIVE: To determine the costs and health effects of interventions to combat breast, cervical, and colorectal cancers in order to guide resource allocation decisions in developing countries. SETTING: Two World Health Organization sub-regions of the world: countries in sub-Saharan Africa with very high adult and high child mortality (AfrE); and countries in South East Asia with high adult and high child mortality (SearD). DESIGN: Cost effectiveness analysis of prevention and treatment strategies for breast, cervical, and colorectal cancer, using mathematical modelling based on a lifetime population model. DATA SOURCES: Demographic and epidemiological data were taken from the WHO mortality and global burden of disease databases. Estimates of intervention coverage, effectiveness, and resource needs were based on clinical trials, treatment guidelines, and expert opinion. Unit costs were taken from the WHO-CHOICE price database. MAIN OUTCOME MEASURES: Cost per disability adjusted life year (DALY) averted, expressed in international dollars ($Int) for the year 2005. RESULTS: In both regions certain interventions in cervical cancer control (screening through cervical smear tests or visual inspection with acetic acid in combination with treatment) and colorectal cancer control (increasing the coverage of treatment interventions) cost <$Int2000 per DALY averted and can be considered highly cost effective. In the sub-Saharan African region screening for colorectal cancer (by colonoscopy at age 50 in combination with treatment) costs $Int2000-6000 per DALY averted and can be considered cost effective. In both regions certain interventions in breast cancer control (treatment of all cancer stages in combination with mammography screening) cost $Int2000-6000 per DALY averted and can also be considered cost effective. Other interventions, such as campaigns to eat more fruit and vegetable or subsidies in colorectal cancer control, are not cost effective according to the criteria defined. CONCLUSION: Highly cost effective interventions to combat cervical and colorectal cancer are available in the African and Asian sub-regions. In cervical cancer control, these include screening through smear tests or visual inspection in combination with treatment. In colorectal cancer, increasing treatment coverage is highly cost effective (screening through colonoscopy is cost effective in the African sub-region). In breast cancer control, mammography screening in combination with treatment of all stages is cost effective. SN - 1756-1833 UR - https://www.unboundmedicine.com/medline/citation/22389347/Cost_effectiveness_of_strategies_to_combat_breast_cervical_and_colorectal_cancer_in_sub_Saharan_Africa_and_South_East_Asia:_mathematical_modelling_study_ L2 - http://www.bmj.com/cgi/pmidlookup?view=long&amp;pmid=22389347 DB - PRIME DP - Unbound Medicine ER -