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Hemodialysis and peritoneal dialysis are associated with similar outcomes for end-stage renal disease treatment in Canada.
Nephrol Dial Transplant. 2012 Sep; 27(9):3568-75.ND

Abstract

BACKGROUND

There were 35 265 patients receiving renal replacement therapy in Canada at the end of 2007 with 11.0% of patients on peritoneal dialysis (PD) and 48.9% on hemodialysis (HD) and a remaining 40.1% living with a functioning kidney transplant. There are no contemporary studies examining PD survival relative to HD in Canada. The objective was to compare survival outcomes for incident patients starting on PD as compared to HD in Canada.

METHODS

Using data from the Canadian Organ Replacement Register, the Cox proportional hazards (PH) model was employed to study survival outcomes for patients initiating PD as compared to HD in Canada from 1991 to 2004 with follow-up to 31 December 2007. Comparisons of outcomes were made between three successive calendar periods: 1991-95, 1996-2000 and 2001-04 with the relative risk of death of incident patients calculated using an intent-to-treat (ITT) analysis with proportional and non-PH models using a piecewise exponential survival model to compare adjusted mortality rates.

RESULTS

In the ITT analysis, overall survival for the entire study period favored PD in the first 18 months and HD after 36 months. However, for the 2001-04 cohort, survival favored PD for the first 2 years and thereafter PD and HD were similar. Among female patients > 65 years with diabetes, PD had a 27% higher mortality rate.

CONCLUSIONS

Overall, HD and PD are associated with similar outcomes for end-stage renal disease treatment in Canada.

Authors+Show Affiliations

Department of Medicine, Queen's University, Kingston, Ontario, Canada. yeatesk@queensu.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22391139

Citation

Yeates, Karen, et al. "Hemodialysis and Peritoneal Dialysis Are Associated With Similar Outcomes for End-stage Renal Disease Treatment in Canada." Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, vol. 27, no. 9, 2012, pp. 3568-75.
Yeates K, Zhu N, Vonesh E, et al. Hemodialysis and peritoneal dialysis are associated with similar outcomes for end-stage renal disease treatment in Canada. Nephrol Dial Transplant. 2012;27(9):3568-75.
Yeates, K., Zhu, N., Vonesh, E., Trpeski, L., Blake, P., & Fenton, S. (2012). Hemodialysis and peritoneal dialysis are associated with similar outcomes for end-stage renal disease treatment in Canada. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, 27(9), 3568-75. https://doi.org/10.1093/ndt/gfr674
Yeates K, et al. Hemodialysis and Peritoneal Dialysis Are Associated With Similar Outcomes for End-stage Renal Disease Treatment in Canada. Nephrol Dial Transplant. 2012;27(9):3568-75. PubMed PMID: 22391139.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hemodialysis and peritoneal dialysis are associated with similar outcomes for end-stage renal disease treatment in Canada. AU - Yeates,Karen, AU - Zhu,Naisu, AU - Vonesh,Edward, AU - Trpeski,Lilyanna, AU - Blake,Peter, AU - Fenton,Stanley, Y1 - 2012/03/05/ PY - 2012/3/7/entrez PY - 2012/3/7/pubmed PY - 2013/7/9/medline SP - 3568 EP - 75 JF - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association JO - Nephrol. Dial. Transplant. VL - 27 IS - 9 N2 - BACKGROUND: There were 35 265 patients receiving renal replacement therapy in Canada at the end of 2007 with 11.0% of patients on peritoneal dialysis (PD) and 48.9% on hemodialysis (HD) and a remaining 40.1% living with a functioning kidney transplant. There are no contemporary studies examining PD survival relative to HD in Canada. The objective was to compare survival outcomes for incident patients starting on PD as compared to HD in Canada. METHODS: Using data from the Canadian Organ Replacement Register, the Cox proportional hazards (PH) model was employed to study survival outcomes for patients initiating PD as compared to HD in Canada from 1991 to 2004 with follow-up to 31 December 2007. Comparisons of outcomes were made between three successive calendar periods: 1991-95, 1996-2000 and 2001-04 with the relative risk of death of incident patients calculated using an intent-to-treat (ITT) analysis with proportional and non-PH models using a piecewise exponential survival model to compare adjusted mortality rates. RESULTS: In the ITT analysis, overall survival for the entire study period favored PD in the first 18 months and HD after 36 months. However, for the 2001-04 cohort, survival favored PD for the first 2 years and thereafter PD and HD were similar. Among female patients > 65 years with diabetes, PD had a 27% higher mortality rate. CONCLUSIONS: Overall, HD and PD are associated with similar outcomes for end-stage renal disease treatment in Canada. SN - 1460-2385 UR - https://www.unboundmedicine.com/medline/citation/22391139/Hemodialysis_and_peritoneal_dialysis_are_associated_with_similar_outcomes_for_end_stage_renal_disease_treatment_in_Canada_ L2 - https://academic.oup.com/ndt/article-lookup/doi/10.1093/ndt/gfr674 DB - PRIME DP - Unbound Medicine ER -