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Olive oil intake and breast cancer risk in the Mediterranean countries of the European Prospective Investigation into Cancer and Nutrition study.

Abstract

Although there is some evidence suggesting that olive oil could reduce breast cancer (BC) risk, the epidemiological data are still relatively limited, not entirely consistent and mainly based on case-control studies. Therefore, we prospectively assessed the association between olive oil and BC risk in postmenopausal women from the Mediterranean cohorts within the European Prospective Investigation into Cancer and Nutrition. The analysis included 62,284 postmenopausal women recruited from Spain, Italy and Greece who had complete dietary data (collected from validated country-specific dietary questionnaires). The risk of BC (overall and by hormone receptor subtypes) was assessed using hazards ratios (HRs) obtained from Cox proportional hazards regression, while adjusting for known BC risk factors. After a mean follow-up of 9 years, 1,256 women were diagnosed with a primary incident invasive BC. The multivariate HRs for BC risk by olive oil intake (highest vs. lowest tertile of g/day/2,000 kcal) were 1.07 (95% CI = 0.91-1.25) in the adjusted model, 1.06 (95% CI = 0.91-1.24) in the model additionally adjusted for reproductive-related factors and 1.10 (95% CI = 0.92-1.31) for the model additionally adjusted for dietary factors. There was no association between olive oil and risk of estrogen or progesterone receptor-positive tumors, but a suggestion of a negative association with estrogens and progesterone receptor-negative tumors. The results from our prospective study showed that olive oil consumption during adult life was not associated with the risk of BC. However, larger prospective studies are still needed to explore possible differences related to hormone receptor status.

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  • Authors+Show Affiliations

    ,

    Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain. gbuckland@iconcologia.net

    , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

    Source

    International journal of cancer 131:10 2012 Nov 15 pg 2465-9

    MeSH

    Breast Neoplasms
    Cohort Studies
    Diet
    Female
    Humans
    Mediterranean Region
    Olive Oil
    Plant Oils
    Postmenopause
    Receptors, Estrogen
    Receptors, Progesterone
    Risk

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22392404

    Citation

    Buckland, Genevieve, et al. "Olive Oil Intake and Breast Cancer Risk in the Mediterranean Countries of the European Prospective Investigation Into Cancer and Nutrition Study." International Journal of Cancer, vol. 131, no. 10, 2012, pp. 2465-9.
    Buckland G, Travier N, Agudo A, et al. Olive oil intake and breast cancer risk in the Mediterranean countries of the European Prospective Investigation into Cancer and Nutrition study. Int J Cancer. 2012;131(10):2465-9.
    Buckland, G., Travier, N., Agudo, A., Fonseca-Nunes, A., Navarro, C., Lagiou, P., ... González, C. A. (2012). Olive oil intake and breast cancer risk in the Mediterranean countries of the European Prospective Investigation into Cancer and Nutrition study. International Journal of Cancer, 131(10), pp. 2465-9. doi:10.1002/ijc.27516.
    Buckland G, et al. Olive Oil Intake and Breast Cancer Risk in the Mediterranean Countries of the European Prospective Investigation Into Cancer and Nutrition Study. Int J Cancer. 2012 Nov 15;131(10):2465-9. PubMed PMID: 22392404.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Olive oil intake and breast cancer risk in the Mediterranean countries of the European Prospective Investigation into Cancer and Nutrition study. AU - Buckland,Genevieve, AU - Travier,Noemie, AU - Agudo,Antonio, AU - Fonseca-Nunes,Ana, AU - Navarro,Carmen, AU - Lagiou,Pagona, AU - Demetriou,Christiana, AU - Amiano,Pilar, AU - Dorronsoro,Miren, AU - Chirlaque,María-Dolores, AU - Huerta,José-María, AU - Molina,Esther, AU - Pérez,Maria-José Sánchez, AU - Ardanaz,Eva, AU - Moreno-Iribas,Conchi, AU - Quirós,J Ramón, AU - Naska,Androniki, AU - Trichopoulos,Dimitrios, AU - Giurdanella,Maria Concetta, AU - Tumino,Rosario, AU - Agnoli,Claudia, AU - Grioni,Sara, AU - Panico,Salvatore, AU - Mattiello,Amalia, AU - Masala,Giovanna, AU - Sacerdote,Carlotta, AU - Polidoro,Silvia, AU - Palli,Domenico, AU - Trichopoulou,Antonia, AU - González,Carlos A, Y1 - 2012/04/04/ PY - 2011/11/07/received PY - 2012/02/13/revised PY - 2012/02/16/accepted PY - 2012/3/7/entrez PY - 2012/3/7/pubmed PY - 2012/12/12/medline SP - 2465 EP - 9 JF - International journal of cancer JO - Int. J. Cancer VL - 131 IS - 10 N2 - Although there is some evidence suggesting that olive oil could reduce breast cancer (BC) risk, the epidemiological data are still relatively limited, not entirely consistent and mainly based on case-control studies. Therefore, we prospectively assessed the association between olive oil and BC risk in postmenopausal women from the Mediterranean cohorts within the European Prospective Investigation into Cancer and Nutrition. The analysis included 62,284 postmenopausal women recruited from Spain, Italy and Greece who had complete dietary data (collected from validated country-specific dietary questionnaires). The risk of BC (overall and by hormone receptor subtypes) was assessed using hazards ratios (HRs) obtained from Cox proportional hazards regression, while adjusting for known BC risk factors. After a mean follow-up of 9 years, 1,256 women were diagnosed with a primary incident invasive BC. The multivariate HRs for BC risk by olive oil intake (highest vs. lowest tertile of g/day/2,000 kcal) were 1.07 (95% CI = 0.91-1.25) in the adjusted model, 1.06 (95% CI = 0.91-1.24) in the model additionally adjusted for reproductive-related factors and 1.10 (95% CI = 0.92-1.31) for the model additionally adjusted for dietary factors. There was no association between olive oil and risk of estrogen or progesterone receptor-positive tumors, but a suggestion of a negative association with estrogens and progesterone receptor-negative tumors. The results from our prospective study showed that olive oil consumption during adult life was not associated with the risk of BC. However, larger prospective studies are still needed to explore possible differences related to hormone receptor status. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/22392404/full_citation L2 - https://doi.org/10.1002/ijc.27516 DB - PRIME DP - Unbound Medicine ER -