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c-Kit proto-oncogene expression in endometrial hyperplasia and endometrial cancer.
Arch Gynecol Obstet. 2012 Jul; 286(1):197-200.AG

Abstract

PURPOSE

To evaluate the expression of c-kit (CD117) in endometrial hyperplasia and endometrial cancer.

METHODS

Expression of c-kit in 10 normal endometrium, 18 simple endometrial hyperplasia, 16 complex endometrial hyperplasia (10 cases with atypia and 6 cases without atypia), and 6 endometrial cancer were investigated by immunohistochemistry.

RESULTS

c-Kit expression decreased as the lesion progressed to endometrial cancer. Immunostaining was mostly focal and weak in the normal endometrium and was mostly diffuse and strong in the simple and complex endometrial hyperplasia.

CONCLUSIONS

Simple and complex hyperplastic endometrial tissues express diffuse cytoplasmic staining for c-kit and the expression decreases with the progression of the lesion.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Inonu University School of Medicine, Malatya, Turkey. ercanyilmazgyn@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22392489

Citation

Yilmaz, Ercan, et al. "C-Kit Proto-oncogene Expression in Endometrial Hyperplasia and Endometrial Cancer." Archives of Gynecology and Obstetrics, vol. 286, no. 1, 2012, pp. 197-200.
Yilmaz E, Celik O, Simsek Y, et al. C-Kit proto-oncogene expression in endometrial hyperplasia and endometrial cancer. Arch Gynecol Obstet. 2012;286(1):197-200.
Yilmaz, E., Celik, O., Simsek, Y., Turkcuoglu, I., Celik, E., Gül, M., Hascalik, S., Aydin, N. E., & Aydin, E. (2012). C-Kit proto-oncogene expression in endometrial hyperplasia and endometrial cancer. Archives of Gynecology and Obstetrics, 286(1), 197-200. https://doi.org/10.1007/s00404-012-2276-8
Yilmaz E, et al. C-Kit Proto-oncogene Expression in Endometrial Hyperplasia and Endometrial Cancer. Arch Gynecol Obstet. 2012;286(1):197-200. PubMed PMID: 22392489.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - c-Kit proto-oncogene expression in endometrial hyperplasia and endometrial cancer. AU - Yilmaz,Ercan, AU - Celik,Onder, AU - Simsek,Yavuz, AU - Turkcuoglu,Ilgin, AU - Celik,Ebru, AU - Gül,Mehmet, AU - Hascalik,Seyma, AU - Aydin,Nasuhi Engin, AU - Aydin,Engin, Y1 - 2012/03/06/ PY - 2011/09/27/received PY - 2012/02/23/accepted PY - 2012/3/7/entrez PY - 2012/3/7/pubmed PY - 2012/12/12/medline SP - 197 EP - 200 JF - Archives of gynecology and obstetrics JO - Arch Gynecol Obstet VL - 286 IS - 1 N2 - PURPOSE: To evaluate the expression of c-kit (CD117) in endometrial hyperplasia and endometrial cancer. METHODS: Expression of c-kit in 10 normal endometrium, 18 simple endometrial hyperplasia, 16 complex endometrial hyperplasia (10 cases with atypia and 6 cases without atypia), and 6 endometrial cancer were investigated by immunohistochemistry. RESULTS: c-Kit expression decreased as the lesion progressed to endometrial cancer. Immunostaining was mostly focal and weak in the normal endometrium and was mostly diffuse and strong in the simple and complex endometrial hyperplasia. CONCLUSIONS: Simple and complex hyperplastic endometrial tissues express diffuse cytoplasmic staining for c-kit and the expression decreases with the progression of the lesion. SN - 1432-0711 UR - https://www.unboundmedicine.com/medline/citation/22392489/c_Kit_proto_oncogene_expression_in_endometrial_hyperplasia_and_endometrial_cancer_ L2 - https://dx.doi.org/10.1007/s00404-012-2276-8 DB - PRIME DP - Unbound Medicine ER -