Tags

Type your tag names separated by a space and hit enter

Changes in parameters of bone metabolism in postmenopausal women following a 12-month intervention period using dairy products enriched with calcium, vitamin D, and phylloquinone (vitamin K(1)) or menaquinone-7 (vitamin K (2)): the Postmenopausal Health Study II.
Calcif Tissue Int 2012; 90(4):251-62CT

Abstract

The objective of the present study was to examine the effect of dairy products enriched with calcium, vitamin D(3), and phylloquinone (vitamin K(1)) or menaquinone-7 (vitamin K(2)) on parameters of bone metabolism in postmenopausal women following a 12-month intervention. Postmenopausal women were divided into three intervention groups and a control group (CG). All three intervention groups attended biweekly sessions and received fortified dairy products providing daily 800 mg of calcium and 10 μg of vitamin D(3) (CaD). Furthermore, in two of the three intervention groups the dairy products were also enriched with vitamin K, providing daily 100 μg of either phylloquinone (CaDK1) or menaquinone-7 (CaDK2). The increase observed for serum 25(OH)D levels in all intervention groups and the increase observed for serum IGF-I levels in the CaDK2 group differed significantly compared to the changes observed in CG (P = 0.010 and P = 0.028, respectively). Furthermore, both the CaDK1 and CaDK2 groups had a significantly lower mean serum undercarboxylated osteocalcin to osteocalcin ratio and urine deoxypyridinoline levels at follow-up compared to the CaD and CG groups (P = 0.001 and P = 0.047, respectively). Significant increases in total-body BMD were observed in all intervention groups compared to CG (P < 0.05), while significant increases in lumbar spine BMD were observed only for CaDK1 and CaDK2 compared to CG (P < 0.05) after controlling for changes in serum 25(OH)D levels and dietary calcium intake. In conclusion, the present study revealed more favorable changes in bone metabolism and bone mass indices for the two vitamin K-supplemented groups, mainly reflected in the suppression of serum levels of bone remodeling indices and in the more positive changes in lumbar spine BMD for these two study groups.

Authors+Show Affiliations

Department of Nutrition and Dietetics, Harokopio University, Kallithea, Athens, Greece.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22392526

Citation

Kanellakis, Spyridon, et al. "Changes in Parameters of Bone Metabolism in Postmenopausal Women Following a 12-month Intervention Period Using Dairy Products Enriched With Calcium, Vitamin D, and Phylloquinone (vitamin K(1)) or Menaquinone-7 (vitamin K (2)): the Postmenopausal Health Study II." Calcified Tissue International, vol. 90, no. 4, 2012, pp. 251-62.
Kanellakis S, Moschonis G, Tenta R, et al. Changes in parameters of bone metabolism in postmenopausal women following a 12-month intervention period using dairy products enriched with calcium, vitamin D, and phylloquinone (vitamin K(1)) or menaquinone-7 (vitamin K (2)): the Postmenopausal Health Study II. Calcif Tissue Int. 2012;90(4):251-62.
Kanellakis, S., Moschonis, G., Tenta, R., Schaafsma, A., van den Heuvel, E. G., Papaioannou, N., ... Manios, Y. (2012). Changes in parameters of bone metabolism in postmenopausal women following a 12-month intervention period using dairy products enriched with calcium, vitamin D, and phylloquinone (vitamin K(1)) or menaquinone-7 (vitamin K (2)): the Postmenopausal Health Study II. Calcified Tissue International, 90(4), pp. 251-62. doi:10.1007/s00223-012-9571-z.
Kanellakis S, et al. Changes in Parameters of Bone Metabolism in Postmenopausal Women Following a 12-month Intervention Period Using Dairy Products Enriched With Calcium, Vitamin D, and Phylloquinone (vitamin K(1)) or Menaquinone-7 (vitamin K (2)): the Postmenopausal Health Study II. Calcif Tissue Int. 2012;90(4):251-62. PubMed PMID: 22392526.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in parameters of bone metabolism in postmenopausal women following a 12-month intervention period using dairy products enriched with calcium, vitamin D, and phylloquinone (vitamin K(1)) or menaquinone-7 (vitamin K (2)): the Postmenopausal Health Study II. AU - Kanellakis,Spyridon, AU - Moschonis,George, AU - Tenta,Roxane, AU - Schaafsma,Anne, AU - van den Heuvel,Ellen G H M, AU - Papaioannou,Nikolaos, AU - Lyritis,George, AU - Manios,Yannis, Y1 - 2012/03/04/ PY - 2011/02/05/received PY - 2011/12/19/accepted PY - 2012/3/7/entrez PY - 2012/3/7/pubmed PY - 2012/10/23/medline SP - 251 EP - 62 JF - Calcified tissue international JO - Calcif. Tissue Int. VL - 90 IS - 4 N2 - The objective of the present study was to examine the effect of dairy products enriched with calcium, vitamin D(3), and phylloquinone (vitamin K(1)) or menaquinone-7 (vitamin K(2)) on parameters of bone metabolism in postmenopausal women following a 12-month intervention. Postmenopausal women were divided into three intervention groups and a control group (CG). All three intervention groups attended biweekly sessions and received fortified dairy products providing daily 800 mg of calcium and 10 μg of vitamin D(3) (CaD). Furthermore, in two of the three intervention groups the dairy products were also enriched with vitamin K, providing daily 100 μg of either phylloquinone (CaDK1) or menaquinone-7 (CaDK2). The increase observed for serum 25(OH)D levels in all intervention groups and the increase observed for serum IGF-I levels in the CaDK2 group differed significantly compared to the changes observed in CG (P = 0.010 and P = 0.028, respectively). Furthermore, both the CaDK1 and CaDK2 groups had a significantly lower mean serum undercarboxylated osteocalcin to osteocalcin ratio and urine deoxypyridinoline levels at follow-up compared to the CaD and CG groups (P = 0.001 and P = 0.047, respectively). Significant increases in total-body BMD were observed in all intervention groups compared to CG (P < 0.05), while significant increases in lumbar spine BMD were observed only for CaDK1 and CaDK2 compared to CG (P < 0.05) after controlling for changes in serum 25(OH)D levels and dietary calcium intake. In conclusion, the present study revealed more favorable changes in bone metabolism and bone mass indices for the two vitamin K-supplemented groups, mainly reflected in the suppression of serum levels of bone remodeling indices and in the more positive changes in lumbar spine BMD for these two study groups. SN - 1432-0827 UR - https://www.unboundmedicine.com/medline/citation/22392526/Changes_in_parameters_of_bone_metabolism_in_postmenopausal_women_following_a_12_month_intervention_period_using_dairy_products_enriched_with_calcium_vitamin_D_and_phylloquinone__vitamin_K_1___or_menaquinone_7__vitamin_K__2__:_the_Postmenopausal_Health_Study_II_ L2 - https://dx.doi.org/10.1007/s00223-012-9571-z DB - PRIME DP - Unbound Medicine ER -