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Impaired ocular blood flow regulation in patients with open-angle glaucoma and diabetes.
Clin Exp Ophthalmol. 2012 Sep-Oct; 40(7):697-705.CE

Abstract

BACKGROUND

To elucidate the potential impact of diabetes mellitus on primary open-angle glaucoma pathology through vascular deficiency.

DESIGN

Cross-section analysis from a longitudinal, prospective study.

PARTICIPANTS

Eighty-four open-angle glaucoma patients (20 diabetic open-angle glaucoma patients and 64 non-diabetic open-angle glaucoma patients)

METHODS

Patients were analyzed for ocular structure, ocular perfusion pressure (OPP), retrobulbar blood flow and retinal capillary perfusion. Statistical analysis was performed by SPSS version 18.0. Comparisons between groups were made as well as multivariate linear regression analysis.

MAIN OUTCOME MEASURE

Retrobulbar blood flow and the retinal microcirculation.

RESULTS

Central retinal artery peak systolic velocity was 13.5% lower in diabetic patients (P = 0.007). In diabetic open-angle glaucoma patients, ocular perfusion pressure positively correlated with central retinal artery and temporal posterior ciliary artery peak systolic velocity (R = 0.476, P = 0.039 and R = 0.529, P = 0.02, respectively), and with central retinal artery and nasal posterior ciliary artery resistance index (R = 0.537, P = 0.018 and R = 0.566, P = 0.012 respectively). Average retinal nerve fibre layer positively correlated with central retinal artery peak systolic velocity and temporal posterior ciliary artery end diastolic velocity (R = 0.501, P = 0.029 and R = 0.553, P = 0.019, respectively), and negatively correlated with superior and inferior retinal avascular space in the diabetic group (R = -0.498, P = 0.030 and R = -0.700, P = 0.001, respectively); no correlations were found in the non-diabetic group. Negative correlations between retrobulbar and retinal circulations were only found in the diabetic open-angle glaucoma patients, whereas positive correlations between retinal flow and non-flow were only found in non-diabetic open-angle glaucoma patients.

CONCLUSION

Diabetes may interfere with normal vascular regulation and contribute to glaucoma progression.

Authors+Show Affiliations

Department of Ophthalmology, Indiana School of Medicine Midwest Eye Institute, 702 Rotary Circle, Indianapolis, IN 46202, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22394354

Citation

Shoshani, Yochai, et al. "Impaired Ocular Blood Flow Regulation in Patients With Open-angle Glaucoma and Diabetes." Clinical & Experimental Ophthalmology, vol. 40, no. 7, 2012, pp. 697-705.
Shoshani Y, Harris A, Shoja MM, et al. Impaired ocular blood flow regulation in patients with open-angle glaucoma and diabetes. Clin Exp Ophthalmol. 2012;40(7):697-705.
Shoshani, Y., Harris, A., Shoja, M. M., Arieli, Y., Ehrlich, R., Primus, S., Ciulla, T., Cantor, A., Wirostko, B., & Siesky, B. A. (2012). Impaired ocular blood flow regulation in patients with open-angle glaucoma and diabetes. Clinical & Experimental Ophthalmology, 40(7), 697-705. https://doi.org/10.1111/j.1442-9071.2012.02778.x
Shoshani Y, et al. Impaired Ocular Blood Flow Regulation in Patients With Open-angle Glaucoma and Diabetes. Clin Exp Ophthalmol. 2012 Sep-Oct;40(7):697-705. PubMed PMID: 22394354.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impaired ocular blood flow regulation in patients with open-angle glaucoma and diabetes. AU - Shoshani,Yochai, AU - Harris,Alon, AU - Shoja,Mohammadali M, AU - Arieli,Yoel, AU - Ehrlich,Rita, AU - Primus,Sally, AU - Ciulla,Thomas, AU - Cantor,Adam, AU - Wirostko,Barbara, AU - Siesky,Brent A, Y1 - 2012/05/17/ PY - 2012/3/8/entrez PY - 2012/3/8/pubmed PY - 2013/1/19/medline SP - 697 EP - 705 JF - Clinical & experimental ophthalmology JO - Clin Exp Ophthalmol VL - 40 IS - 7 N2 - BACKGROUND: To elucidate the potential impact of diabetes mellitus on primary open-angle glaucoma pathology through vascular deficiency. DESIGN: Cross-section analysis from a longitudinal, prospective study. PARTICIPANTS: Eighty-four open-angle glaucoma patients (20 diabetic open-angle glaucoma patients and 64 non-diabetic open-angle glaucoma patients) METHODS: Patients were analyzed for ocular structure, ocular perfusion pressure (OPP), retrobulbar blood flow and retinal capillary perfusion. Statistical analysis was performed by SPSS version 18.0. Comparisons between groups were made as well as multivariate linear regression analysis. MAIN OUTCOME MEASURE: Retrobulbar blood flow and the retinal microcirculation. RESULTS: Central retinal artery peak systolic velocity was 13.5% lower in diabetic patients (P = 0.007). In diabetic open-angle glaucoma patients, ocular perfusion pressure positively correlated with central retinal artery and temporal posterior ciliary artery peak systolic velocity (R = 0.476, P = 0.039 and R = 0.529, P = 0.02, respectively), and with central retinal artery and nasal posterior ciliary artery resistance index (R = 0.537, P = 0.018 and R = 0.566, P = 0.012 respectively). Average retinal nerve fibre layer positively correlated with central retinal artery peak systolic velocity and temporal posterior ciliary artery end diastolic velocity (R = 0.501, P = 0.029 and R = 0.553, P = 0.019, respectively), and negatively correlated with superior and inferior retinal avascular space in the diabetic group (R = -0.498, P = 0.030 and R = -0.700, P = 0.001, respectively); no correlations were found in the non-diabetic group. Negative correlations between retrobulbar and retinal circulations were only found in the diabetic open-angle glaucoma patients, whereas positive correlations between retinal flow and non-flow were only found in non-diabetic open-angle glaucoma patients. CONCLUSION: Diabetes may interfere with normal vascular regulation and contribute to glaucoma progression. SN - 1442-9071 UR - https://www.unboundmedicine.com/medline/citation/22394354/Impaired_ocular_blood_flow_regulation_in_patients_with_open_angle_glaucoma_and_diabetes_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=22394354.ui DB - PRIME DP - Unbound Medicine ER -