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The cellular and signaling networks linking the immune system and metabolism in disease.
Nat Med. 2012 Mar 06; 18(3):363-74.NMed

Abstract

It is now recognized that obesity is driving the type 2 diabetes epidemic in Western countries. Obesity-associated chronic tissue inflammation is a key contributing factor to type 2 diabetes and cardiovascular disease, and a number of studies have clearly demonstrated that the immune system and metabolism are highly integrated. Recent advances in deciphering the various cellular and signaling networks that participate in linking the immune and metabolic systems together have contributed to understanding of the pathogenesis of metabolic diseases and may also inform new therapeutic strategies based on immunomodulation. Here we discuss how these various networks underlie the etiology of the inflammatory component of insulin resistance, with a particular focus on the central roles of macrophages in adipose tissue and liver.

Authors+Show Affiliations

Department of Medicine, Division of Endocrinology and Metabolism, University of California-San Diego, La Jolla, California, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22395709

Citation

Osborn, Olivia, and Jerrold M. Olefsky. "The Cellular and Signaling Networks Linking the Immune System and Metabolism in Disease." Nature Medicine, vol. 18, no. 3, 2012, pp. 363-74.
Osborn O, Olefsky JM. The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med. 2012;18(3):363-74.
Osborn, O., & Olefsky, J. M. (2012). The cellular and signaling networks linking the immune system and metabolism in disease. Nature Medicine, 18(3), 363-74. https://doi.org/10.1038/nm.2627
Osborn O, Olefsky JM. The Cellular and Signaling Networks Linking the Immune System and Metabolism in Disease. Nat Med. 2012 Mar 6;18(3):363-74. PubMed PMID: 22395709.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The cellular and signaling networks linking the immune system and metabolism in disease. AU - Osborn,Olivia, AU - Olefsky,Jerrold M, Y1 - 2012/03/06/ PY - 2012/3/8/entrez PY - 2012/3/8/pubmed PY - 2012/6/19/medline SP - 363 EP - 74 JF - Nature medicine JO - Nat Med VL - 18 IS - 3 N2 - It is now recognized that obesity is driving the type 2 diabetes epidemic in Western countries. Obesity-associated chronic tissue inflammation is a key contributing factor to type 2 diabetes and cardiovascular disease, and a number of studies have clearly demonstrated that the immune system and metabolism are highly integrated. Recent advances in deciphering the various cellular and signaling networks that participate in linking the immune and metabolic systems together have contributed to understanding of the pathogenesis of metabolic diseases and may also inform new therapeutic strategies based on immunomodulation. Here we discuss how these various networks underlie the etiology of the inflammatory component of insulin resistance, with a particular focus on the central roles of macrophages in adipose tissue and liver. SN - 1546-170X UR - https://www.unboundmedicine.com/medline/citation/22395709/The_cellular_and_signaling_networks_linking_the_immune_system_and_metabolism_in_disease_ L2 - https://doi.org/10.1038/nm.2627 DB - PRIME DP - Unbound Medicine ER -