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Impaired thermoregulation and thyroid function in iron-deficiency anemia.

Abstract

Ten women with iron-deficiency anemia, 8 with depleted iron stores (nonanemic), and 12 control women, all of similar body fatness, were exposed to a 28 degrees C water bath to test the hypothesis that iron-deficiency anemia impairs thermoregulatory performance. The anemic women had lower rectal temperatures than did control women (36.0 +/- 0.2 vs 36.2 +/- 0.1 degree C, respectively, P = 0.001) and a lower rate of oxygen consumption (5.28 +/- 0.26 vs 5.99 +/- 0.29 mL.min-1.kg body wt-1, respectively, P = 0.04) at 100 min of cold exposure. Plasma thyroxine and triiodothyronine concentrations were significantly (P less than 0.002) lower in anemic than in control women at baseline and during cold exposure. Responses of iron-depleted subjects were similar to those of control subjects. Iron supplementation corrected the anemia, significantly (P = 0.03) improved rectal temperature at 100 min, and partially normalized plasma thyroid hormone concentrations. Plasma catecholamines were unaffected by iron status. This experiment demonstrates a functional consequence of iron-deficiency anemia in the balance of heat production and loss and suggests that thyroid-hormone metabolism may be responsible.

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    • Grapherence [↓13]

    Authors+Show Affiliations

    Beard JL
    ,

    Department of Nutrition, Pennsylvania State University, University Park 16802.

    Borel MJ
    ,
    Derr J

    Source

    MeSH

    Adult
    Anemia, Hypochromic
    Body Temperature Regulation
    Cold Temperature
    Cross-Sectional Studies
    Female
    Humans
    Iron
    Longitudinal Studies
    Thyroid Gland
    Thyroxine
    Triiodothyronine

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, Non-P.H.S.

    Language

    eng

    PubMed ID

    2239756

    Citation

    Beard, J L., et al. "Impaired Thermoregulation and Thyroid Function in Iron-deficiency Anemia." The American Journal of Clinical Nutrition, vol. 52, no. 5, 1990, pp. 813-9.
    Beard JL, Borel MJ, Derr J. Impaired thermoregulation and thyroid function in iron-deficiency anemia. Am J Clin Nutr. 1990;52(5):813-9.
    Beard, J. L., Borel, M. J., & Derr, J. (1990). Impaired thermoregulation and thyroid function in iron-deficiency anemia. The American Journal of Clinical Nutrition, 52(5), pp. 813-9.
    Beard JL, Borel MJ, Derr J. Impaired Thermoregulation and Thyroid Function in Iron-deficiency Anemia. Am J Clin Nutr. 1990;52(5):813-9. PubMed PMID: 2239756.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Impaired thermoregulation and thyroid function in iron-deficiency anemia. AU - Beard,J L, AU - Borel,M J, AU - Derr,J, PY - 1990/11/1/pubmed PY - 1990/11/1/medline PY - 1990/11/1/entrez SP - 813 EP - 9 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 52 IS - 5 N2 - Ten women with iron-deficiency anemia, 8 with depleted iron stores (nonanemic), and 12 control women, all of similar body fatness, were exposed to a 28 degrees C water bath to test the hypothesis that iron-deficiency anemia impairs thermoregulatory performance. The anemic women had lower rectal temperatures than did control women (36.0 +/- 0.2 vs 36.2 +/- 0.1 degree C, respectively, P = 0.001) and a lower rate of oxygen consumption (5.28 +/- 0.26 vs 5.99 +/- 0.29 mL.min-1.kg body wt-1, respectively, P = 0.04) at 100 min of cold exposure. Plasma thyroxine and triiodothyronine concentrations were significantly (P less than 0.002) lower in anemic than in control women at baseline and during cold exposure. Responses of iron-depleted subjects were similar to those of control subjects. Iron supplementation corrected the anemia, significantly (P = 0.03) improved rectal temperature at 100 min, and partially normalized plasma thyroid hormone concentrations. Plasma catecholamines were unaffected by iron status. This experiment demonstrates a functional consequence of iron-deficiency anemia in the balance of heat production and loss and suggests that thyroid-hormone metabolism may be responsible. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/2239756/full_citation L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/52.5.813 DB - PRIME DP - Unbound Medicine ER -