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Vitamin D as a therapy for colitis: a systematic review.
J Crohns Colitis 2012; 6(4):405-11JC

Abstract

BACKGROUND AND AIM

The effect of vitamin D supplementation on immune disorders has been a topical research focus. The aim of this systematic review was to examine the current evidence of the effect of vitamin D supplementation as a therapy for colitis.

METHODS

The following databases were searched: MEDLINE, Pubmed, Scopus, Web of Knowledge, Cinicaltrials.gov and the Cochrane Central Register of Controlled Trials using the terms 'inflammatory bowel disease' 'Crohn's disease' 'ulcerative colitis' 'colitis' [and] 'vitamin D'. Both human and animal studies published in English language were examined. The reference lists of included studies and review articles were manually searched for any relevant studies.

RESULTS

Four studies were included in this systematic review. All reported an improvement in disease activity with vitamin D supplementation. The only high quality human study reported a non-significant reduction of relapse rate for Crohn's disease. No major adverse effects of vitamin D supplementation were reported.

CONCLUSIONS

Although there is some evidence that supplemental vitamin D, as an adjunctive treatment, may help in controlling colitis, this evidence is not enough to justify using vitamin D in treating inflammatory bowel disease (IBD). Large high quality placebo-controlled randomised controlled trials are needed to explore a possible benefit of using vitamin D in treating IBD.

Authors+Show Affiliations

Division of Paediatric Gastroenterology, Hepatology and Nutrition, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review
Systematic Review

Language

eng

PubMed ID

22398085

Citation

Nicholson, Imogen, et al. "Vitamin D as a Therapy for Colitis: a Systematic Review." Journal of Crohn's & Colitis, vol. 6, no. 4, 2012, pp. 405-11.
Nicholson I, Dalzell AM, El-Matary W. Vitamin D as a therapy for colitis: a systematic review. J Crohns Colitis. 2012;6(4):405-11.
Nicholson, I., Dalzell, A. M., & El-Matary, W. (2012). Vitamin D as a therapy for colitis: a systematic review. Journal of Crohn's & Colitis, 6(4), pp. 405-11. doi:10.1016/j.crohns.2012.01.007.
Nicholson I, Dalzell AM, El-Matary W. Vitamin D as a Therapy for Colitis: a Systematic Review. J Crohns Colitis. 2012;6(4):405-11. PubMed PMID: 22398085.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D as a therapy for colitis: a systematic review. AU - Nicholson,Imogen, AU - Dalzell,A Mark, AU - El-Matary,Wael, Y1 - 2012/01/27/ PY - 2011/11/20/received PY - 2012/01/05/revised PY - 2012/01/05/accepted PY - 2012/3/9/entrez PY - 2012/3/9/pubmed PY - 2013/4/23/medline SP - 405 EP - 11 JF - Journal of Crohn's & colitis JO - J Crohns Colitis VL - 6 IS - 4 N2 - BACKGROUND AND AIM: The effect of vitamin D supplementation on immune disorders has been a topical research focus. The aim of this systematic review was to examine the current evidence of the effect of vitamin D supplementation as a therapy for colitis. METHODS: The following databases were searched: MEDLINE, Pubmed, Scopus, Web of Knowledge, Cinicaltrials.gov and the Cochrane Central Register of Controlled Trials using the terms 'inflammatory bowel disease' 'Crohn's disease' 'ulcerative colitis' 'colitis' [and] 'vitamin D'. Both human and animal studies published in English language were examined. The reference lists of included studies and review articles were manually searched for any relevant studies. RESULTS: Four studies were included in this systematic review. All reported an improvement in disease activity with vitamin D supplementation. The only high quality human study reported a non-significant reduction of relapse rate for Crohn's disease. No major adverse effects of vitamin D supplementation were reported. CONCLUSIONS: Although there is some evidence that supplemental vitamin D, as an adjunctive treatment, may help in controlling colitis, this evidence is not enough to justify using vitamin D in treating inflammatory bowel disease (IBD). Large high quality placebo-controlled randomised controlled trials are needed to explore a possible benefit of using vitamin D in treating IBD. SN - 1876-4479 UR - https://www.unboundmedicine.com/medline/citation/22398085/Vitamin_D_as_a_therapy_for_colitis:_a_systematic_review_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1873-9946(12)00012-8 DB - PRIME DP - Unbound Medicine ER -