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Associations of intakes of fat, dietary fiber, soy isoflavones, and alcohol with levels of sex hormones and prolactin in premenopausal Japanese women.

Abstract

OBJECTIVE

Endogenous sex hormones have been implicated in the etiology of breast cancer. Dietary factors such as fat, dietary fiber, soy isoflavones, and alcohol have been suggested to influence endogenous estrogen and other steroid hormone levels. We examined the relationship among these dietary factors and plasma sex hormone levels in premenopausal Japanese women.

METHODS

We measured the plasma concentrations of estradiol, estrone, testosterone, dehydroepiandrosterone sulfate, sex hormone-binding globulin, a follicle-stimulating hormone, a luteinizing hormone, and prolactin among 393 premenopausal women who had regular menstrual cycles fewer than 40 days apart. The dietary intakes were estimated with a validated food frequency questionnaire.

RESULTS

After controlling for age, BMI, phase of the menstrual cycle, number of births, age at first birth, history of breastfeeding, and smoking status, the saturated fat intake was significantly positively associated with total estradiol and free estradiol levels. Intakes of the other types of fat, dietary fiber, soy isoflavones, and alcohol were not significantly associated with levels of any hormone measured.

CONCLUSIONS

These data suggest that a high intake of saturated fat is associated with increased estradiol levels in premenopausal Japanese women. Saturated fat intake may have implications in the etiology of breast cancer.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, Gifu, Gifu, Japan. o2111706@edu.gifu-u.ac.jp

    , , , , , ,

    Source

    Cancer causes & control : CCC 23:5 2012 May pg 683-9

    MeSH

    Adult
    Asian Continental Ancestry Group
    Dietary Fats
    Dietary Fiber
    Ethanol
    Female
    Gonadal Steroid Hormones
    Humans
    Isoflavones
    Premenopause
    Prolactin

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22399233

    Citation

    Tsuji, Michiko, et al. "Associations of Intakes of Fat, Dietary Fiber, Soy Isoflavones, and Alcohol With Levels of Sex Hormones and Prolactin in Premenopausal Japanese Women." Cancer Causes & Control : CCC, vol. 23, no. 5, 2012, pp. 683-9.
    Tsuji M, Tamai Y, Wada K, et al. Associations of intakes of fat, dietary fiber, soy isoflavones, and alcohol with levels of sex hormones and prolactin in premenopausal Japanese women. Cancer Causes Control. 2012;23(5):683-9.
    Tsuji, M., Tamai, Y., Wada, K., Nakamura, K., Hayashi, M., Takeda, N., ... Nagata, C. (2012). Associations of intakes of fat, dietary fiber, soy isoflavones, and alcohol with levels of sex hormones and prolactin in premenopausal Japanese women. Cancer Causes & Control : CCC, 23(5), pp. 683-9. doi:10.1007/s10552-012-9935-8.
    Tsuji M, et al. Associations of Intakes of Fat, Dietary Fiber, Soy Isoflavones, and Alcohol With Levels of Sex Hormones and Prolactin in Premenopausal Japanese Women. Cancer Causes Control. 2012;23(5):683-9. PubMed PMID: 22399233.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Associations of intakes of fat, dietary fiber, soy isoflavones, and alcohol with levels of sex hormones and prolactin in premenopausal Japanese women. AU - Tsuji,Michiko, AU - Tamai,Yuya, AU - Wada,Keiko, AU - Nakamura,Kozue, AU - Hayashi,Makoto, AU - Takeda,Noriyuki, AU - Yasuda,Keigo, AU - Nagata,Chisato, Y1 - 2012/03/08/ PY - 2011/11/10/received PY - 2012/02/24/accepted PY - 2012/3/9/entrez PY - 2012/3/9/pubmed PY - 2012/10/23/medline SP - 683 EP - 9 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 23 IS - 5 N2 - OBJECTIVE: Endogenous sex hormones have been implicated in the etiology of breast cancer. Dietary factors such as fat, dietary fiber, soy isoflavones, and alcohol have been suggested to influence endogenous estrogen and other steroid hormone levels. We examined the relationship among these dietary factors and plasma sex hormone levels in premenopausal Japanese women. METHODS: We measured the plasma concentrations of estradiol, estrone, testosterone, dehydroepiandrosterone sulfate, sex hormone-binding globulin, a follicle-stimulating hormone, a luteinizing hormone, and prolactin among 393 premenopausal women who had regular menstrual cycles fewer than 40 days apart. The dietary intakes were estimated with a validated food frequency questionnaire. RESULTS: After controlling for age, BMI, phase of the menstrual cycle, number of births, age at first birth, history of breastfeeding, and smoking status, the saturated fat intake was significantly positively associated with total estradiol and free estradiol levels. Intakes of the other types of fat, dietary fiber, soy isoflavones, and alcohol were not significantly associated with levels of any hormone measured. CONCLUSIONS: These data suggest that a high intake of saturated fat is associated with increased estradiol levels in premenopausal Japanese women. Saturated fat intake may have implications in the etiology of breast cancer. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/22399233/Associations_of_intakes_of_fat_dietary_fiber_soy_isoflavones_and_alcohol_with_levels_of_sex_hormones_and_prolactin_in_premenopausal_Japanese_women_ L2 - https://doi.org/10.1007/s10552-012-9935-8 DB - PRIME DP - Unbound Medicine ER -