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Cardiometabolic risk profiles and carotid atherosclerosis in individuals with prediabetes identified by fasting glucose, postchallenge glucose, and hemoglobin A1c criteria.
Diabetes Care. 2012 May; 35(5):1144-9.DC

Abstract

OBJECTIVE

We evaluated whether cardiometabolic risk profiles differ for subjects identified as having prediabetes by A1C, fasting glucose (FPG), or 2-h postchallenge glucose (2-PG) criteria.

RESEARCH DESIGN AND METHODS

Atherosclerosis risk factors, oral glucose tolerance test, and ultrasound measurement of carotid intima-media thickness (IMT) were analyzed in 780 nondiabetic individuals.

RESULTS

Poor agreement existed for A1C and FPG criteria for identification of subjects with prediabetes (κ coefficient = 0.332). No differences in cardiometabolic risk profiles were observed among the three groups of individuals with prediabetes by A1C only, FPG only, and both A1C and FPG. Poor agreement also existed for A1C and 2-PG criteria for identification of individuals with prediabetes (κ coefficient = 0.299). No significant differences in cardiometabolic risk factors were observed between IGT-only and individuals with prediabetes by A1C and 2-PG. Compared with subjects with prediabetes identified by A1C only, IGT-only individuals exhibited a worse cardiometabolic risk profile, with significantly higher systolic blood pressure, pulse pressure, 2-h postchallenge insulin, triglycerides, high-sensitivity C-reactive protein, and carotid IMT, and lower HDL cholesterol levels and insulin sensitivity.

CONCLUSIONS

These results suggest that considerable discordance between A1C, FPG, and 2-PG exists for the identification of individuals with prediabetes and that the cardiometabolic risk profile of these individuals varies by metabolic parameter, with 2-PG showing the stronger association with cardiometabolic risk factors and subclinical atherosclerosis than FPG or A1C.

Authors+Show Affiliations

Department of InternalMedicine, University of Rome-Tor Vergata, Rome, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22399698

Citation

Marini, Maria A., et al. "Cardiometabolic Risk Profiles and Carotid Atherosclerosis in Individuals With Prediabetes Identified By Fasting Glucose, Postchallenge Glucose, and Hemoglobin A1c Criteria." Diabetes Care, vol. 35, no. 5, 2012, pp. 1144-9.
Marini MA, Succurro E, Castaldo E, et al. Cardiometabolic risk profiles and carotid atherosclerosis in individuals with prediabetes identified by fasting glucose, postchallenge glucose, and hemoglobin A1c criteria. Diabetes Care. 2012;35(5):1144-9.
Marini, M. A., Succurro, E., Castaldo, E., Cufone, S., Arturi, F., Sciacqua, A., Lauro, R., Hribal, M. L., Perticone, F., & Sesti, G. (2012). Cardiometabolic risk profiles and carotid atherosclerosis in individuals with prediabetes identified by fasting glucose, postchallenge glucose, and hemoglobin A1c criteria. Diabetes Care, 35(5), 1144-9. https://doi.org/10.2337/dc11-2032
Marini MA, et al. Cardiometabolic Risk Profiles and Carotid Atherosclerosis in Individuals With Prediabetes Identified By Fasting Glucose, Postchallenge Glucose, and Hemoglobin A1c Criteria. Diabetes Care. 2012;35(5):1144-9. PubMed PMID: 22399698.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiometabolic risk profiles and carotid atherosclerosis in individuals with prediabetes identified by fasting glucose, postchallenge glucose, and hemoglobin A1c criteria. AU - Marini,Maria A, AU - Succurro,Elena, AU - Castaldo,Ersilia, AU - Cufone,Sabrina, AU - Arturi,Franco, AU - Sciacqua,Angela, AU - Lauro,Renato, AU - Hribal,Marta L, AU - Perticone,Francesco, AU - Sesti,Giorgio, Y1 - 2012/03/07/ PY - 2012/3/9/entrez PY - 2012/3/9/pubmed PY - 2012/8/10/medline SP - 1144 EP - 9 JF - Diabetes care JO - Diabetes Care VL - 35 IS - 5 N2 - OBJECTIVE: We evaluated whether cardiometabolic risk profiles differ for subjects identified as having prediabetes by A1C, fasting glucose (FPG), or 2-h postchallenge glucose (2-PG) criteria. RESEARCH DESIGN AND METHODS: Atherosclerosis risk factors, oral glucose tolerance test, and ultrasound measurement of carotid intima-media thickness (IMT) were analyzed in 780 nondiabetic individuals. RESULTS: Poor agreement existed for A1C and FPG criteria for identification of subjects with prediabetes (κ coefficient = 0.332). No differences in cardiometabolic risk profiles were observed among the three groups of individuals with prediabetes by A1C only, FPG only, and both A1C and FPG. Poor agreement also existed for A1C and 2-PG criteria for identification of individuals with prediabetes (κ coefficient = 0.299). No significant differences in cardiometabolic risk factors were observed between IGT-only and individuals with prediabetes by A1C and 2-PG. Compared with subjects with prediabetes identified by A1C only, IGT-only individuals exhibited a worse cardiometabolic risk profile, with significantly higher systolic blood pressure, pulse pressure, 2-h postchallenge insulin, triglycerides, high-sensitivity C-reactive protein, and carotid IMT, and lower HDL cholesterol levels and insulin sensitivity. CONCLUSIONS: These results suggest that considerable discordance between A1C, FPG, and 2-PG exists for the identification of individuals with prediabetes and that the cardiometabolic risk profile of these individuals varies by metabolic parameter, with 2-PG showing the stronger association with cardiometabolic risk factors and subclinical atherosclerosis than FPG or A1C. SN - 1935-5548 UR - https://www.unboundmedicine.com/medline/citation/22399698/Cardiometabolic_risk_profiles_and_carotid_atherosclerosis_in_individuals_with_prediabetes_identified_by_fasting_glucose_postchallenge_glucose_and_hemoglobin_A1c_criteria_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&pmid=22399698 DB - PRIME DP - Unbound Medicine ER -