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Antenatal microbiologic and maternal risk factors associated with prematurity.
Am J Obstet Gynecol. 1990 Nov; 163(5 Pt 1):1465-73.AJ

Abstract

In a prospective study of 202 women (gestational age 24 +/- 4 weeks), we evaluated possible influences of lower genital tract infection or bacterial conditions on obstetric outcomes, including preterm labor, preterm premature rupture of membranes, and preterm birth. The presence of bacterial vaginosis (18.7%) was associated with an increased risk of preterm labor (relative risk, 2.6; 95% confidence interval, 1.08 to 6.46). For women with bacterial vaginosis who also had Mobiluncus species morphotypes identified on Gram stain, the relative risk of preterm labor was 3.8 (95% confidence interval, 1.32 to 11.5). Presence of vaginal Mycoplasma hominis (10.8% of patients) was associated with both preterm labor (relative risk, 1.8; 95% confidence interval, 0.77 to 4.4) and preterm birth (relative risk, 5.1; 95% confidence interval, 1.45 to 17.9). Recovery of Staphylococcus aureus (3.0%) was associated with preterm labor (relative risk, 3.1; 95% confidence interval 1.12 to 8.7). Identification of two or more bacterial-linked abnormalities was also associated with preterm labor (relative risk, 3.3; 95% confidence interval, 1.44 to 7.58). An increased level of vaginal wash protease (greater than or equal to 10 trypsin units) (16%) was associated with preterm labor and was noted in 50% of women with preterm premature rupture of membranes. A history of prior preterm birth was the single best historical predictor of both preterm labor (relative risk, 3.6; 95% confidence interval, 1.92 to 6.83) and preterm birth (relative risk, 6.7; 95% confidence interval, 2.2 to 20.4). History of three or more abortions, antenatal urinary tract infection, and occurrence of medical complications during pregnancy also correlated with increased risk of preterm labor. These findings affirm and refine associations of various maternal reproductive tract infections with preterm labor, premature rupture of membranes, and birth, allowing for controlled treatment trials aimed at prevention of preterm birth.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, University of Colorado Health Sciences Center, Denver 80262.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2240089

Citation

McGregor, J A., et al. "Antenatal Microbiologic and Maternal Risk Factors Associated With Prematurity." American Journal of Obstetrics and Gynecology, vol. 163, no. 5 Pt 1, 1990, pp. 1465-73.
McGregor JA, French JI, Richter R, et al. Antenatal microbiologic and maternal risk factors associated with prematurity. Am J Obstet Gynecol. 1990;163(5 Pt 1):1465-73.
McGregor, J. A., French, J. I., Richter, R., Franco-Buff, A., Johnson, A., Hillier, S., Judson, F. N., & Todd, J. K. (1990). Antenatal microbiologic and maternal risk factors associated with prematurity. American Journal of Obstetrics and Gynecology, 163(5 Pt 1), 1465-73.
McGregor JA, et al. Antenatal Microbiologic and Maternal Risk Factors Associated With Prematurity. Am J Obstet Gynecol. 1990;163(5 Pt 1):1465-73. PubMed PMID: 2240089.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antenatal microbiologic and maternal risk factors associated with prematurity. AU - McGregor,J A, AU - French,J I, AU - Richter,R, AU - Franco-Buff,A, AU - Johnson,A, AU - Hillier,S, AU - Judson,F N, AU - Todd,J K, PY - 1990/11/1/pubmed PY - 1990/11/1/medline PY - 1990/11/1/entrez SP - 1465 EP - 73 JF - American journal of obstetrics and gynecology JO - Am J Obstet Gynecol VL - 163 IS - 5 Pt 1 N2 - In a prospective study of 202 women (gestational age 24 +/- 4 weeks), we evaluated possible influences of lower genital tract infection or bacterial conditions on obstetric outcomes, including preterm labor, preterm premature rupture of membranes, and preterm birth. The presence of bacterial vaginosis (18.7%) was associated with an increased risk of preterm labor (relative risk, 2.6; 95% confidence interval, 1.08 to 6.46). For women with bacterial vaginosis who also had Mobiluncus species morphotypes identified on Gram stain, the relative risk of preterm labor was 3.8 (95% confidence interval, 1.32 to 11.5). Presence of vaginal Mycoplasma hominis (10.8% of patients) was associated with both preterm labor (relative risk, 1.8; 95% confidence interval, 0.77 to 4.4) and preterm birth (relative risk, 5.1; 95% confidence interval, 1.45 to 17.9). Recovery of Staphylococcus aureus (3.0%) was associated with preterm labor (relative risk, 3.1; 95% confidence interval 1.12 to 8.7). Identification of two or more bacterial-linked abnormalities was also associated with preterm labor (relative risk, 3.3; 95% confidence interval, 1.44 to 7.58). An increased level of vaginal wash protease (greater than or equal to 10 trypsin units) (16%) was associated with preterm labor and was noted in 50% of women with preterm premature rupture of membranes. A history of prior preterm birth was the single best historical predictor of both preterm labor (relative risk, 3.6; 95% confidence interval, 1.92 to 6.83) and preterm birth (relative risk, 6.7; 95% confidence interval, 2.2 to 20.4). History of three or more abortions, antenatal urinary tract infection, and occurrence of medical complications during pregnancy also correlated with increased risk of preterm labor. These findings affirm and refine associations of various maternal reproductive tract infections with preterm labor, premature rupture of membranes, and birth, allowing for controlled treatment trials aimed at prevention of preterm birth. SN - 0002-9378 UR - https://www.unboundmedicine.com/medline/citation/2240089/Antenatal_microbiologic_and_maternal_risk_factors_associated_with_prematurity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0002-9378(90)90607-9 DB - PRIME DP - Unbound Medicine ER -