Tags

Type your tag names separated by a space and hit enter

Construction of polycyclic spiro-indolines via an intramolecular oxidative coupling/cyclization cascade reaction process.
Org Lett. 2012 Mar 16; 14(6):1405-7.OL

Abstract

An efficient protocol for assembling a polycyclic spiroindoline scaffold is developed, which involves an intramolecular oxidative coupling of dianions derived from indole-embodied β-ketoamides using iodine as the oxidant, and subsequent attack of oxygen anion to the resultant imine moiety. A number of tetracyclic spiroindolines are prepared with moderate to good yields.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Fan F
School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Xie W
No affiliation info available
Ma D
No affiliation info available

MeSH

CatalysisCyclizationIndolesMolecular StructureOxidative CouplingPolycyclic Aromatic HydrocarbonsSpiro Compounds

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22400980

Citation

Fan, Feng, et al. "Construction of Polycyclic Spiro-indolines Via an Intramolecular Oxidative Coupling/cyclization Cascade Reaction Process." Organic Letters, vol. 14, no. 6, 2012, pp. 1405-7.
Fan F, Xie W, Ma D. Construction of polycyclic spiro-indolines via an intramolecular oxidative coupling/cyclization cascade reaction process. Org Lett. 2012;14(6):1405-7.
Fan, F., Xie, W., & Ma, D. (2012). Construction of polycyclic spiro-indolines via an intramolecular oxidative coupling/cyclization cascade reaction process. Organic Letters, 14(6), 1405-7. https://doi.org/10.1021/ol3003496
Fan F, Xie W, Ma D. Construction of Polycyclic Spiro-indolines Via an Intramolecular Oxidative Coupling/cyclization Cascade Reaction Process. Org Lett. 2012 Mar 16;14(6):1405-7. PubMed PMID: 22400980.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Construction of polycyclic spiro-indolines via an intramolecular oxidative coupling/cyclization cascade reaction process. AU - Fan,Feng, AU - Xie,Weiqing, AU - Ma,Dawei, Y1 - 2012/03/08/ PY - 2012/3/10/entrez PY - 2012/3/10/pubmed PY - 2012/6/13/medline SP - 1405 EP - 7 JF - Organic letters JO - Org Lett VL - 14 IS - 6 N2 - An efficient protocol for assembling a polycyclic spiroindoline scaffold is developed, which involves an intramolecular oxidative coupling of dianions derived from indole-embodied β-ketoamides using iodine as the oxidant, and subsequent attack of oxygen anion to the resultant imine moiety. A number of tetracyclic spiroindolines are prepared with moderate to good yields. SN - 1523-7052 UR - https://www.unboundmedicine.com/medline/citation/22400980/Construction_of_polycyclic_spiro_indolines_via_an_intramolecular_oxidative_coupling/cyclization_cascade_reaction_process_ L2 - https://doi.org/10.1021/ol3003496 DB - PRIME DP - Unbound Medicine ER -