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The effect of lipoic acid and vitamin E therapies in individuals with the metabolic syndrome.
Nutr Metab Cardiovasc Dis. 2013 Jun; 23(6):543-9.NM

Abstract

The metabolic syndrome is associated with abnormal glucose and lipid metabolism, insulin resistance, increased oxidative stress and pro-inflammatory activity that increase the risk of type 2 diabetes and cardiovascular disease. The aim of this study was to investigate the effect of treatment with the antioxidant α-lipoic acid (ALA) with or without vitamin E supplementation, on markers of insulin resistance and systemic inflammation and plasma nonesterified fatty acid (NEFA) concentrations in individuals with the metabolic syndrome. In a randomized, double-blind, placebo-controlled trial, subjects with the metabolic syndrome received ALA (600 mg/day, n = 34), vitamin E (100 IU/day, n = 36), both ALA and vitamin E (n = 41), or matching placebo (n = 40) for 1 year. Fasting circulating concentrations of glucose and insulin were measure every 3 months and NEFA, markers of inflammation, adiponectin and vitamin E were measured at 6 monthly intervals. Plasma NEFA concentrations decreased [-10 (-18, 0)%] at a marginal level of significance (p = 0.05) in those who received ALA alone compared with placebo and decreased [-8 (-14, -1)% (95% CI)] significantly (P = 0.02) in participants who were randomised to ALA with and without vitamin E compared with those who did not receive ALA. Fasting glucose, insulin, homeostatic model assessment of insulin resistance, adiponectin, and markers of inflammation did not change significantly during the study. These data suggest that prolonged treatment with ALA may modestly reduce plasma NEFA concentrations but does not alter insulin or glucose levels in individuals with the metabolic syndrome.

Authors+Show Affiliations

Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand. PatrickManning@healthotago.co.nzNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22402059

Citation

Manning, P J., et al. "The Effect of Lipoic Acid and Vitamin E Therapies in Individuals With the Metabolic Syndrome." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 23, no. 6, 2013, pp. 543-9.
Manning PJ, Sutherland WH, Williams SM, et al. The effect of lipoic acid and vitamin E therapies in individuals with the metabolic syndrome. Nutr Metab Cardiovasc Dis. 2013;23(6):543-9.
Manning, P. J., Sutherland, W. H., Williams, S. M., Walker, R. J., Berry, E. A., De Jong, S. A., & Ryalls, A. R. (2013). The effect of lipoic acid and vitamin E therapies in individuals with the metabolic syndrome. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 23(6), 543-9. https://doi.org/10.1016/j.numecd.2011.11.006
Manning PJ, et al. The Effect of Lipoic Acid and Vitamin E Therapies in Individuals With the Metabolic Syndrome. Nutr Metab Cardiovasc Dis. 2013;23(6):543-9. PubMed PMID: 22402059.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of lipoic acid and vitamin E therapies in individuals with the metabolic syndrome. AU - Manning,P J, AU - Sutherland,W H F, AU - Williams,S M, AU - Walker,R J, AU - Berry,E A, AU - De Jong,S A, AU - Ryalls,A R, Y1 - 2012/03/07/ PY - 2011/08/11/received PY - 2011/11/01/revised PY - 2011/11/17/accepted PY - 2012/3/10/entrez PY - 2012/3/10/pubmed PY - 2014/1/31/medline SP - 543 EP - 9 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 23 IS - 6 N2 - The metabolic syndrome is associated with abnormal glucose and lipid metabolism, insulin resistance, increased oxidative stress and pro-inflammatory activity that increase the risk of type 2 diabetes and cardiovascular disease. The aim of this study was to investigate the effect of treatment with the antioxidant α-lipoic acid (ALA) with or without vitamin E supplementation, on markers of insulin resistance and systemic inflammation and plasma nonesterified fatty acid (NEFA) concentrations in individuals with the metabolic syndrome. In a randomized, double-blind, placebo-controlled trial, subjects with the metabolic syndrome received ALA (600 mg/day, n = 34), vitamin E (100 IU/day, n = 36), both ALA and vitamin E (n = 41), or matching placebo (n = 40) for 1 year. Fasting circulating concentrations of glucose and insulin were measure every 3 months and NEFA, markers of inflammation, adiponectin and vitamin E were measured at 6 monthly intervals. Plasma NEFA concentrations decreased [-10 (-18, 0)%] at a marginal level of significance (p = 0.05) in those who received ALA alone compared with placebo and decreased [-8 (-14, -1)% (95% CI)] significantly (P = 0.02) in participants who were randomised to ALA with and without vitamin E compared with those who did not receive ALA. Fasting glucose, insulin, homeostatic model assessment of insulin resistance, adiponectin, and markers of inflammation did not change significantly during the study. These data suggest that prolonged treatment with ALA may modestly reduce plasma NEFA concentrations but does not alter insulin or glucose levels in individuals with the metabolic syndrome. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/22402059/The_effect_of_lipoic_acid_and_vitamin_E_therapies_in_individuals_with_the_metabolic_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(11)00263-8 DB - PRIME DP - Unbound Medicine ER -