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Microdialysis--a versatile technology to perform metabolic monitoring in diabetes and critically ill patients.
Diabetes Res Clin Pract. 2012 Jul; 97(1):112-8.DR

Abstract

Continuous subcutaneous glucose monitoring has been tested in type 1 diabetes (T1D). Since in critically ill patients vascular access is granted vascular microdialysis may be preferential. To test this hypothesis comparative accuracy data for microdialysis applied for peripheral venous and subcutaneous glucose monitoring was obtained in experiments in T1D patients. Twelve T1D patients were investigated for up to 30 h. Extracorporeal vascular (MDv) and subcutaneous microdialysis (MDs) was performed. Microdialysis samples were collected in 15-60 min intervals, analyzed for glucose and calibrated to reference. MDv and MDs glucose levels were compared against reference. Median absolute relative difference was 14.0 (5.0; 28.0)% (MDv) and 9.2 (4.4; 18.4)% (MDs). Clarke Error Grid analysis showed that 100% (MDv) and 98.8% (MDv) were within zones A and B. Extracorporeal vascular and standard subcutaneous microdialysis indicated similar performance in T1D. We suggest microdialysis as a versatile technology for metabolite monitoring in subcutaneous tissue and whole blood.

Authors+Show Affiliations

Department of Internal Medicine, Medical University of Graz, Graz, Austria. julia.mader@medunigraz.atNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22402305

Citation

Mader, Julia K., et al. "Microdialysis--a Versatile Technology to Perform Metabolic Monitoring in Diabetes and Critically Ill Patients." Diabetes Research and Clinical Practice, vol. 97, no. 1, 2012, pp. 112-8.
Mader JK, Feichtner F, Bock G, et al. Microdialysis--a versatile technology to perform metabolic monitoring in diabetes and critically ill patients. Diabetes Res Clin Pract. 2012;97(1):112-8.
Mader, J. K., Feichtner, F., Bock, G., Köhler, G., Schaller, R., Plank, J., Pieber, T. R., & Ellmerer, M. (2012). Microdialysis--a versatile technology to perform metabolic monitoring in diabetes and critically ill patients. Diabetes Research and Clinical Practice, 97(1), 112-8. https://doi.org/10.1016/j.diabres.2012.02.010
Mader JK, et al. Microdialysis--a Versatile Technology to Perform Metabolic Monitoring in Diabetes and Critically Ill Patients. Diabetes Res Clin Pract. 2012;97(1):112-8. PubMed PMID: 22402305.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microdialysis--a versatile technology to perform metabolic monitoring in diabetes and critically ill patients. AU - Mader,Julia K, AU - Feichtner,Franz, AU - Bock,Gerlies, AU - Köhler,Gerd, AU - Schaller,Roland, AU - Plank,Johannes, AU - Pieber,Thomas R, AU - Ellmerer,Martin, Y1 - 2012/03/07/ PY - 2011/11/20/received PY - 2012/01/20/revised PY - 2012/02/14/accepted PY - 2012/3/10/entrez PY - 2012/3/10/pubmed PY - 2012/12/10/medline SP - 112 EP - 8 JF - Diabetes research and clinical practice JO - Diabetes Res Clin Pract VL - 97 IS - 1 N2 - Continuous subcutaneous glucose monitoring has been tested in type 1 diabetes (T1D). Since in critically ill patients vascular access is granted vascular microdialysis may be preferential. To test this hypothesis comparative accuracy data for microdialysis applied for peripheral venous and subcutaneous glucose monitoring was obtained in experiments in T1D patients. Twelve T1D patients were investigated for up to 30 h. Extracorporeal vascular (MDv) and subcutaneous microdialysis (MDs) was performed. Microdialysis samples were collected in 15-60 min intervals, analyzed for glucose and calibrated to reference. MDv and MDs glucose levels were compared against reference. Median absolute relative difference was 14.0 (5.0; 28.0)% (MDv) and 9.2 (4.4; 18.4)% (MDs). Clarke Error Grid analysis showed that 100% (MDv) and 98.8% (MDv) were within zones A and B. Extracorporeal vascular and standard subcutaneous microdialysis indicated similar performance in T1D. We suggest microdialysis as a versatile technology for metabolite monitoring in subcutaneous tissue and whole blood. SN - 1872-8227 UR - https://www.unboundmedicine.com/medline/citation/22402305/Microdialysis__a_versatile_technology_to_perform_metabolic_monitoring_in_diabetes_and_critically_ill_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(12)00078-2 DB - PRIME DP - Unbound Medicine ER -