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Airway smooth muscle hypertrophy and hyperplasia in asthma.
Am J Respir Crit Care Med. 2012 May 15; 185(10):1058-64.AJ

Abstract

RATIONALE

Increased thickness of the airway smooth muscle (ASM) layer in asthma may result from hyperplasia or hypertrophy of muscle cells or increased extracellular matrix (ECM).

OBJECTIVES

To relate ASM hypertrophy, ASM hyperplasia, and deposition of ECM to the severity and duration of asthma.

METHODS

Airways from control subjects (n = 51) and from cases of nonfatal (n = 49) and fatal (n = 55) asthma were examined postmortem. Mean ASM cell volume (V(C)), the number of ASM cells per length of airway (N(L)), and the volume fraction of extracellular matrix (f(ECM)) within the ASM layer were estimated. Comparisons between subject groups were made on the basis of general linear regression models.

MEASUREMENTS AND MAIN RESULTS

Mean V(C) was increased in the large airways of cases of nonfatal asthma (P = 0.015) and fatal asthma (P < 0.001) compared with control subjects. N(L) was similar in nonfatal cases and control subjects but increased in large (P < 0.001), medium (P < 0.001), and small (P = 0.034) airways of cases of fatal asthma compared with control subjects and with nonfatal cases (large and medium airways, P ≤ 0.003). The f(ECM) was similar in cases of asthma and control subjects. Duration of asthma was associated with a small increase in N(L).

CONCLUSIONS

Hypertrophy of ASM cells occurs in the large airways in both nonfatal and fatal cases of asthma, but hyperplasia of ASM cells is present in the large and small airways in fatal asthma cases only. Both are associated with an absolute increase in ECM. Duration of asthma has little or no effect on ASM hypertrophy or hyperplasia or f(ECM).

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Authors+Show Affiliations

James AL
Department of Pulmonary Physiology and Sleep Medicine/West Australian Sleep Disorders Research Institute, Level 5, G Block, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, Western Australia 6009, Australia. Alan.James.SCGH@health.wa.gov.au
Elliot JG
No affiliation info available
Jones RL
No affiliation info available
Carroll ML
No affiliation info available
Mauad T
No affiliation info available
Bai TR
No affiliation info available
Abramson MJ
No affiliation info available
McKay KO
No affiliation info available
Green FH
No affiliation info available

MeSH

AdolescentAdultAirway RemodelingAsthmaBronchiCase-Control StudiesExtracellular MatrixFemaleHumansHyperplasiaHypertrophyLinear ModelsMaleMiddle AgedMuscle, SmoothSeverity of Illness IndexYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22403800

Citation

James, Alan L., et al. "Airway Smooth Muscle Hypertrophy and Hyperplasia in Asthma." American Journal of Respiratory and Critical Care Medicine, vol. 185, no. 10, 2012, pp. 1058-64.
James AL, Elliot JG, Jones RL, et al. Airway smooth muscle hypertrophy and hyperplasia in asthma. Am J Respir Crit Care Med. 2012;185(10):1058-64.
James, A. L., Elliot, J. G., Jones, R. L., Carroll, M. L., Mauad, T., Bai, T. R., Abramson, M. J., McKay, K. O., & Green, F. H. (2012). Airway smooth muscle hypertrophy and hyperplasia in asthma. American Journal of Respiratory and Critical Care Medicine, 185(10), 1058-64. https://doi.org/10.1164/rccm.201110-1849OC
James AL, et al. Airway Smooth Muscle Hypertrophy and Hyperplasia in Asthma. Am J Respir Crit Care Med. 2012 May 15;185(10):1058-64. PubMed PMID: 22403800.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Airway smooth muscle hypertrophy and hyperplasia in asthma. AU - James,Alan L, AU - Elliot,John G, AU - Jones,Robyn L, AU - Carroll,Mark L, AU - Mauad,Thais, AU - Bai,Tony R, AU - Abramson,Michael J, AU - McKay,Karen O, AU - Green,Francis H, Y1 - 2012/03/08/ PY - 2012/3/10/entrez PY - 2012/3/10/pubmed PY - 2012/7/28/medline SP - 1058 EP - 64 JF - American journal of respiratory and critical care medicine JO - Am J Respir Crit Care Med VL - 185 IS - 10 N2 - RATIONALE: Increased thickness of the airway smooth muscle (ASM) layer in asthma may result from hyperplasia or hypertrophy of muscle cells or increased extracellular matrix (ECM). OBJECTIVES: To relate ASM hypertrophy, ASM hyperplasia, and deposition of ECM to the severity and duration of asthma. METHODS: Airways from control subjects (n = 51) and from cases of nonfatal (n = 49) and fatal (n = 55) asthma were examined postmortem. Mean ASM cell volume (V(C)), the number of ASM cells per length of airway (N(L)), and the volume fraction of extracellular matrix (f(ECM)) within the ASM layer were estimated. Comparisons between subject groups were made on the basis of general linear regression models. MEASUREMENTS AND MAIN RESULTS: Mean V(C) was increased in the large airways of cases of nonfatal asthma (P = 0.015) and fatal asthma (P < 0.001) compared with control subjects. N(L) was similar in nonfatal cases and control subjects but increased in large (P < 0.001), medium (P < 0.001), and small (P = 0.034) airways of cases of fatal asthma compared with control subjects and with nonfatal cases (large and medium airways, P ≤ 0.003). The f(ECM) was similar in cases of asthma and control subjects. Duration of asthma was associated with a small increase in N(L). CONCLUSIONS: Hypertrophy of ASM cells occurs in the large airways in both nonfatal and fatal cases of asthma, but hyperplasia of ASM cells is present in the large and small airways in fatal asthma cases only. Both are associated with an absolute increase in ECM. Duration of asthma has little or no effect on ASM hypertrophy or hyperplasia or f(ECM). SN - 1535-4970 UR - https://www.unboundmedicine.com/medline/citation/22403800/Airway_smooth_muscle_hypertrophy_and_hyperplasia_in_asthma_ L2 - https://www.atsjournals.org/doi/10.1164/rccm.201110-1849OC?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -