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Perioperative administration of gabapentin for shoulder arthroscopy: a prospective, randomized, double-blind, placebo-controlled study.
AANA J. 2011 Aug; 79(4 Suppl):S43-50.AJ

Abstract

Recent studies suggest gabapentin has opioid-sparing effects and may reduce acute postoperative pain. However, there is limited research on the efficacy of gabapentin when combined in a multimodal approach after shoulder arthroscopy under general anesthesia with an interscalene block. We conducted prospective, double-blind study of 70 patients who were randomized to receive either 300 mg of gabapentin or placebo 1 hour before surgery, then twice a day for 2 days. The primary outcome was average pain scores. Secondary outcomes included differences in morphine equivalents, adverse effects, and sleep patterns. No significant differences in pain scores were found on day 1 (gabapentin mean [SD], 4.23 [2.61], vs placebo, 4.61 [2.57]; P = .58) or day 2 (gabapentin, 4.26 [2.39], vs placebo, 4.03 [2.34]; P = .71). Total morphine equivalents on day 1 (gabapentin, 9.75 mg [6.58 mg], vs placebo, 9.52 mg [4.75 mg]; P = .88) and day 2 (gabapentin, 9.21 mg [6.66 mg], vs placebo, 6.93 mg [5.44 mg]; P = .17) were similar. Adverse effects and sleep patterns were similar (P > .05). These results suggest this dosing regimen of gabapentin is not efficacious in improving outcomes in patients undergoing shoulder arthroscopy under general anesthesia with an interscalene block.

Authors+Show Affiliations

Uniformed Services University of the Health Sciences, Graduate School of Nursing, Nurse Anesthesia Program, Naval Medical Center, San Diego, California, USA. dennis.spence@med.navy.milNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

22403966

Citation

Spence, Dennis, et al. "Perioperative Administration of Gabapentin for Shoulder Arthroscopy: a Prospective, Randomized, Double-blind, Placebo-controlled Study." AANA Journal, vol. 79, no. 4 Suppl, 2011, pp. S43-50.
Spence D, Goff J, Mohan E, et al. Perioperative administration of gabapentin for shoulder arthroscopy: a prospective, randomized, double-blind, placebo-controlled study. AANA J. 2011;79(4 Suppl):S43-50.
Spence, D., Goff, J., Mohan, E., Bowen, K., Osborne, L., & Maye, J. (2011). Perioperative administration of gabapentin for shoulder arthroscopy: a prospective, randomized, double-blind, placebo-controlled study. AANA Journal, 79(4 Suppl), S43-50.
Spence D, et al. Perioperative Administration of Gabapentin for Shoulder Arthroscopy: a Prospective, Randomized, Double-blind, Placebo-controlled Study. AANA J. 2011;79(4 Suppl):S43-50. PubMed PMID: 22403966.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Perioperative administration of gabapentin for shoulder arthroscopy: a prospective, randomized, double-blind, placebo-controlled study. AU - Spence,Dennis, AU - Goff,Jason, AU - Mohan,Erin, AU - Bowen,Kirsten, AU - Osborne,Lisa, AU - Maye,John, PY - 2012/3/13/entrez PY - 2012/3/13/pubmed PY - 2012/5/2/medline SP - S43 EP - 50 JF - AANA journal JO - AANA J VL - 79 IS - 4 Suppl N2 - Recent studies suggest gabapentin has opioid-sparing effects and may reduce acute postoperative pain. However, there is limited research on the efficacy of gabapentin when combined in a multimodal approach after shoulder arthroscopy under general anesthesia with an interscalene block. We conducted prospective, double-blind study of 70 patients who were randomized to receive either 300 mg of gabapentin or placebo 1 hour before surgery, then twice a day for 2 days. The primary outcome was average pain scores. Secondary outcomes included differences in morphine equivalents, adverse effects, and sleep patterns. No significant differences in pain scores were found on day 1 (gabapentin mean [SD], 4.23 [2.61], vs placebo, 4.61 [2.57]; P = .58) or day 2 (gabapentin, 4.26 [2.39], vs placebo, 4.03 [2.34]; P = .71). Total morphine equivalents on day 1 (gabapentin, 9.75 mg [6.58 mg], vs placebo, 9.52 mg [4.75 mg]; P = .88) and day 2 (gabapentin, 9.21 mg [6.66 mg], vs placebo, 6.93 mg [5.44 mg]; P = .17) were similar. Adverse effects and sleep patterns were similar (P > .05). These results suggest this dosing regimen of gabapentin is not efficacious in improving outcomes in patients undergoing shoulder arthroscopy under general anesthesia with an interscalene block. SN - 0094-6354 UR - https://www.unboundmedicine.com/medline/citation/22403966/Perioperative_administration_of_gabapentin_for_shoulder_arthroscopy:_a_prospective_randomized_double_blind_placebo_controlled_study_ DB - PRIME DP - Unbound Medicine ER -