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Immunogenicity of one dose of Vero cell culture-derived Japanese encephalitis (JE) vaccine in adults previously vaccinated with mouse brain-derived JE vaccine.
Vaccine. 2012 Apr 26; 30(20):3090-6.V

Abstract

BACKGROUND

There are no data on the use of inactivated Vero cell culture-derived Japanese encephalitis (JE) vaccine (JE-VC) as a booster among individuals who previously received inactivated mouse brain-derived JE vaccine (JE-MB).

METHODS

Military personnel who received ≥3 doses of JE-MB or were JE vaccine-naïve were vaccinated with 2 doses of JE-VC on days 0 and 28. Serum neutralizing antibodies were measured pre-vaccination and 28 days after each dose. Non-inferiority was evaluated for seroprotection rate and geometric mean titer (GMT) between previously vaccinated participants post-dose 1 and vaccine-naïve participants post-dose 2.

RESULTS

Fifty-three previously vaccinated and 70 JE vaccine-naïve participants were enrolled. Previously vaccinated participants had significantly higher GMTs pre-vaccination, post-dose 1, and post-dose 2. Seroprotection rates among previously vaccinated participants post-dose 1 (44/44, 100%) were noninferior to those achieved in previously naïve participants post-dose 2 (53/57, 93%). The GMT was significantly higher in previously vaccinated participants post-dose 1 (GMT 315; 95% CI 191-520) compared to previously naïve participants post-dose 2 (GMT 79; 95% CI 54-114).

CONCLUSIONS

Among military personnel previously vaccinated with ≥3 doses of JE-MB, a single dose of JE-VC adequately boosts neutralizing antibody levels and provides at least short-term protection. Additional studies are needed to confirm these findings in other populations and determine the duration of protection following a single dose of JE-VC in prior recipients of JE-MB.

Authors+Show Affiliations

Department of Operational Infectious Diseases, Naval Health Research Center, San Diego, CA 92106, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

22406277

Citation

Woolpert, Tabitha, et al. "Immunogenicity of One Dose of Vero Cell Culture-derived Japanese Encephalitis (JE) Vaccine in Adults Previously Vaccinated With Mouse Brain-derived JE Vaccine." Vaccine, vol. 30, no. 20, 2012, pp. 3090-6.
Woolpert T, Staples JE, Faix DJ, et al. Immunogenicity of one dose of Vero cell culture-derived Japanese encephalitis (JE) vaccine in adults previously vaccinated with mouse brain-derived JE vaccine. Vaccine. 2012;30(20):3090-6.
Woolpert, T., Staples, J. E., Faix, D. J., Nett, R. J., Kosoy, O. I., Biggerstaff, B. J., Johnson, B. W., Sracic, M., & Fischer, M. (2012). Immunogenicity of one dose of Vero cell culture-derived Japanese encephalitis (JE) vaccine in adults previously vaccinated with mouse brain-derived JE vaccine. Vaccine, 30(20), 3090-6. https://doi.org/10.1016/j.vaccine.2012.02.063
Woolpert T, et al. Immunogenicity of One Dose of Vero Cell Culture-derived Japanese Encephalitis (JE) Vaccine in Adults Previously Vaccinated With Mouse Brain-derived JE Vaccine. Vaccine. 2012 Apr 26;30(20):3090-6. PubMed PMID: 22406277.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunogenicity of one dose of Vero cell culture-derived Japanese encephalitis (JE) vaccine in adults previously vaccinated with mouse brain-derived JE vaccine. AU - Woolpert,Tabitha, AU - Staples,J Erin, AU - Faix,Dennis J, AU - Nett,Randall J, AU - Kosoy,Olga I, AU - Biggerstaff,Brad J, AU - Johnson,Barbara W, AU - Sracic,Michael, AU - Fischer,Marc, Y1 - 2012/03/06/ PY - 2011/12/05/received PY - 2012/02/08/revised PY - 2012/02/22/accepted PY - 2012/3/13/entrez PY - 2012/3/13/pubmed PY - 2012/7/31/medline SP - 3090 EP - 6 JF - Vaccine JO - Vaccine VL - 30 IS - 20 N2 - BACKGROUND: There are no data on the use of inactivated Vero cell culture-derived Japanese encephalitis (JE) vaccine (JE-VC) as a booster among individuals who previously received inactivated mouse brain-derived JE vaccine (JE-MB). METHODS: Military personnel who received ≥3 doses of JE-MB or were JE vaccine-naïve were vaccinated with 2 doses of JE-VC on days 0 and 28. Serum neutralizing antibodies were measured pre-vaccination and 28 days after each dose. Non-inferiority was evaluated for seroprotection rate and geometric mean titer (GMT) between previously vaccinated participants post-dose 1 and vaccine-naïve participants post-dose 2. RESULTS: Fifty-three previously vaccinated and 70 JE vaccine-naïve participants were enrolled. Previously vaccinated participants had significantly higher GMTs pre-vaccination, post-dose 1, and post-dose 2. Seroprotection rates among previously vaccinated participants post-dose 1 (44/44, 100%) were noninferior to those achieved in previously naïve participants post-dose 2 (53/57, 93%). The GMT was significantly higher in previously vaccinated participants post-dose 1 (GMT 315; 95% CI 191-520) compared to previously naïve participants post-dose 2 (GMT 79; 95% CI 54-114). CONCLUSIONS: Among military personnel previously vaccinated with ≥3 doses of JE-MB, a single dose of JE-VC adequately boosts neutralizing antibody levels and provides at least short-term protection. Additional studies are needed to confirm these findings in other populations and determine the duration of protection following a single dose of JE-VC in prior recipients of JE-MB. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/22406277/Immunogenicity_of_one_dose_of_Vero_cell_culture_derived_Japanese_encephalitis__JE__vaccine_in_adults_previously_vaccinated_with_mouse_brain_derived_JE_vaccine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(12)00270-8 DB - PRIME DP - Unbound Medicine ER -