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New cytotoxic quinolone alkaloids from fruits of Evodia rutaecarpa.
Fitoterapia. 2012 Jun; 83(4):709-14.F

Abstract

Three new quinolone alkaloids, 1-methyl-2-[7-hydroxy-(E)-9-tridecenyl]-4(1H)-quinolone (1), 1-methyl-2-[(Z)-4-nonenyl]-4(1H)-quinolone (2), 1-methyl-2-[(1E,5Z)-1,5-undecadienyl]-4(1H)-quinolone (3) and one new natural product, 1-methyl-2-[(E)-1-undecenyl]-4(1H)-quinolone (4), were isolated from the dried and nearly ripe fruits of Evodia rutaecarpa (Juss.) Benth., along with thirteen known compounds (5-17). In addition, one new artificial product, 1-methyl-2-[7-carbonyl-(E)-9-tridecenyl]-4(1H)-quinolone (1A) was also obtained. The structures of these compounds were determined by spectroscopic analyses. The cytotoxic activities of all of the compounds against the human cancer cell lines HL-60, N-87, H-460, and Hep G(2) cells were evaluated by MTT assay. The results showed that these alkaloids inhibited cell proliferation with IC(50) values between 14μM and 22μM.

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Authors+Show Affiliations

Huang X
State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing 100191, PR China. huangx_132@163.com
Li W
No affiliation info available
Yang XW
No affiliation info available

MeSH

AlkaloidsAntineoplastic Agents, PhytogenicEvodiaFruitHep G2 CellsHumansInhibitory Concentration 50Molecular StructureNeoplasmsPhytotherapyPlant ExtractsQuinolones

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22406451

Citation

Huang, Xin, et al. "New Cytotoxic Quinolone Alkaloids From Fruits of Evodia Rutaecarpa." Fitoterapia, vol. 83, no. 4, 2012, pp. 709-14.
Huang X, Li W, Yang XW. New cytotoxic quinolone alkaloids from fruits of Evodia rutaecarpa. Fitoterapia. 2012;83(4):709-14.
Huang, X., Li, W., & Yang, X. W. (2012). New cytotoxic quinolone alkaloids from fruits of Evodia rutaecarpa. Fitoterapia, 83(4), 709-14. https://doi.org/10.1016/j.fitote.2012.02.009
Huang X, Li W, Yang XW. New Cytotoxic Quinolone Alkaloids From Fruits of Evodia Rutaecarpa. Fitoterapia. 2012;83(4):709-14. PubMed PMID: 22406451.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New cytotoxic quinolone alkaloids from fruits of Evodia rutaecarpa. AU - Huang,Xin, AU - Li,Wei, AU - Yang,Xiu-Wei, Y1 - 2012/03/02/ PY - 2011/11/20/received PY - 2012/02/20/revised PY - 2012/02/22/accepted PY - 2012/3/13/entrez PY - 2012/3/13/pubmed PY - 2012/9/28/medline SP - 709 EP - 14 JF - Fitoterapia JO - Fitoterapia VL - 83 IS - 4 N2 - Three new quinolone alkaloids, 1-methyl-2-[7-hydroxy-(E)-9-tridecenyl]-4(1H)-quinolone (1), 1-methyl-2-[(Z)-4-nonenyl]-4(1H)-quinolone (2), 1-methyl-2-[(1E,5Z)-1,5-undecadienyl]-4(1H)-quinolone (3) and one new natural product, 1-methyl-2-[(E)-1-undecenyl]-4(1H)-quinolone (4), were isolated from the dried and nearly ripe fruits of Evodia rutaecarpa (Juss.) Benth., along with thirteen known compounds (5-17). In addition, one new artificial product, 1-methyl-2-[7-carbonyl-(E)-9-tridecenyl]-4(1H)-quinolone (1A) was also obtained. The structures of these compounds were determined by spectroscopic analyses. The cytotoxic activities of all of the compounds against the human cancer cell lines HL-60, N-87, H-460, and Hep G(2) cells were evaluated by MTT assay. The results showed that these alkaloids inhibited cell proliferation with IC(50) values between 14μM and 22μM. SN - 1873-6971 UR - https://www.unboundmedicine.com/medline/citation/22406451/New_cytotoxic_quinolone_alkaloids_from_fruits_of_Evodia_rutaecarpa_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0367-326X(12)00060-3 DB - PRIME DP - Unbound Medicine ER -