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Increased risk of uveitis in coeliac disease: a nationwide cohort study.

Abstract

BACKGROUND

Case reports suggest a potential association between coeliac disease (CD) and uveitis, but larger well-controlled studies are lacking. The aim of this study was therefore to examine the risk of uveitis in patients with biopsy-verified CD.

METHODS

Small intestinal biopsy reports performed between July 1969 and February 2008 were collected from all (n=28) pathology departments in Sweden. From these reports, 29,044 patients with CD (equals villous atrophy, Marsh 3) were identified. Uveitis was defined according to relevant International Classification of Disease codes in the Swedish National Patient Register. Cox regression was used to estimate HR for uveitis in individuals with CD compared with those in reference individuals matched for age, sex, county and calendar year.

RESULTS

During follow-up, 148 patients with CD developed uveitis (expected count 112), corresponding to a HR of 1.32 (95% CI 1.10 to 1.58). The absolute risk of uveitis was 50/100,000 person-years in CD. The risk estimate did not change more than marginally when adjusted for type 1 diabetes, rheumatoid arthritis and autoimmune thyroid disease (HR 1.30; 95% CI 1.08 to 1.56). The risk of uveitis remained significantly increased even 5 years after CD diagnosis (HR 1.31; 95% CI 1.04 to 1.64).

CONCLUSION

A moderately increased risk of uveitis was found in patients with biopsy-verified CD. CD might be considered in patients with uveitis of unknown aetiology.

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  • Authors+Show Affiliations

    ,

    Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm 171 76, Sweden. kaziwe.mollazadegan@ki.se

    , ,

    Source

    The British journal of ophthalmology 96:6 2012 Jun pg 857-61

    MeSH

    Adolescent
    Adult
    Aged
    Aged, 80 and over
    Biopsy
    Celiac Disease
    Child
    Child, Preschool
    Female
    Humans
    Infant
    Infant, Newborn
    Intestine, Small
    Male
    Middle Aged
    Risk Factors
    Uveitis
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22408231

    Citation

    Mollazadegan, Kaziwe, et al. "Increased Risk of Uveitis in Coeliac Disease: a Nationwide Cohort Study." The British Journal of Ophthalmology, vol. 96, no. 6, 2012, pp. 857-61.
    Mollazadegan K, Kugelberg M, Tallstedt L, et al. Increased risk of uveitis in coeliac disease: a nationwide cohort study. Br J Ophthalmol. 2012;96(6):857-61.
    Mollazadegan, K., Kugelberg, M., Tallstedt, L., & Ludvigsson, J. F. (2012). Increased risk of uveitis in coeliac disease: a nationwide cohort study. The British Journal of Ophthalmology, 96(6), pp. 857-61. doi:10.1136/bjophthalmol-2011-301051.
    Mollazadegan K, et al. Increased Risk of Uveitis in Coeliac Disease: a Nationwide Cohort Study. Br J Ophthalmol. 2012;96(6):857-61. PubMed PMID: 22408231.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Increased risk of uveitis in coeliac disease: a nationwide cohort study. AU - Mollazadegan,Kaziwe, AU - Kugelberg,Maria, AU - Tallstedt,Leif, AU - Ludvigsson,Jonas F, Y1 - 2012/03/09/ PY - 2012/3/13/entrez PY - 2012/3/13/pubmed PY - 2012/7/20/medline SP - 857 EP - 61 JF - The British journal of ophthalmology JO - Br J Ophthalmol VL - 96 IS - 6 N2 - BACKGROUND: Case reports suggest a potential association between coeliac disease (CD) and uveitis, but larger well-controlled studies are lacking. The aim of this study was therefore to examine the risk of uveitis in patients with biopsy-verified CD. METHODS: Small intestinal biopsy reports performed between July 1969 and February 2008 were collected from all (n=28) pathology departments in Sweden. From these reports, 29,044 patients with CD (equals villous atrophy, Marsh 3) were identified. Uveitis was defined according to relevant International Classification of Disease codes in the Swedish National Patient Register. Cox regression was used to estimate HR for uveitis in individuals with CD compared with those in reference individuals matched for age, sex, county and calendar year. RESULTS: During follow-up, 148 patients with CD developed uveitis (expected count 112), corresponding to a HR of 1.32 (95% CI 1.10 to 1.58). The absolute risk of uveitis was 50/100,000 person-years in CD. The risk estimate did not change more than marginally when adjusted for type 1 diabetes, rheumatoid arthritis and autoimmune thyroid disease (HR 1.30; 95% CI 1.08 to 1.56). The risk of uveitis remained significantly increased even 5 years after CD diagnosis (HR 1.31; 95% CI 1.04 to 1.64). CONCLUSION: A moderately increased risk of uveitis was found in patients with biopsy-verified CD. CD might be considered in patients with uveitis of unknown aetiology. SN - 1468-2079 UR - https://www.unboundmedicine.com/medline/citation/22408231/Increased_risk_of_uveitis_in_coeliac_disease:_a_nationwide_cohort_study_ L2 - http://bjo.bmj.com/cgi/pmidlookup?view=long&pmid=22408231 DB - PRIME DP - Unbound Medicine ER -