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Association between circulating cytokine levels, diabetes and insulin resistance in a population-based sample (CoLaus study).
Clin Endocrinol (Oxf). 2013 Feb; 78(2):232-41.CE

Abstract

OBJECTIVE

The associations between inflammation, diabetes and insulin resistance remain controversial. Hence, we assessed the associations between diabetes, insulin resistance (using HOMA-IR) and metabolic syndrome with the inflammatory markers high-sensitive C-reactive protein (hs-CRP), interleukin-1 beta (IL-1β), interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α).

DESIGN

Cross-sectional study.

PARTICIPANTS

Two thousand eight hundred and eighty-four men and 3201 women, aged 35-75, participated in this study.

METHODS

C-reactive protein was assessed by immunoassay and cytokines by multiplexed flow cytometric assay. In a subgroup of 532 participants, an oral glucose tolerance test (OGTT) was performed to screen for impaired glucose tolerance (IGT).

RESULTS

IL-6, TNF-α and hs-CRP were significantly and positively correlated with fasting plasma glucose (FPG), insulin and HOMA-IR. Participants with diabetes had higher IL-6, TNF-α and hs-CRP levels than participants without diabetes; this difference persisted for hs-CRP after multivariate adjustment. Participants with metabolic syndrome had increased IL-6, TNF-α and hs-CRP levels; these differences persisted after multivariate adjustment. Participants in the highest quartile of HOMA-IR had increased IL-6, TNF-α and hs-CRP levels; these differences persisted for TNF-α and hs-CRP after multivariate adjustment. No association was found between IL-1β levels and all diabetes and insulin resistance markers studied. Finally, participants with IGT had higher hs-CRP levels than participants with a normal OGTT, but this difference disappeared after controlling for body mass index (BMI).

CONCLUSION

We found that subjects with diabetes, metabolic syndrome and increased insulin resistance had increased levels of IL6, TNF-α and hs-CRP, while no association was found with IL-1β. The increased inflammatory state of subjects with IGT is partially explained by increased BMI.

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Authors+Show Affiliations

Marques-Vidal P
Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Lausanne, Switzerland. Pedro-Manuel.Marques-Vidal@chuv.ch
Bastardot F
No affiliation info available
von Känel R
No affiliation info available
Paccaud F
No affiliation info available
Preisig M
No affiliation info available
Waeber G
No affiliation info available
Vollenweider P
No affiliation info available

MeSH

AdultAgedBiomarkersCross-Sectional StudiesCytokinesDiabetes Mellitus, Type 2FemaleGlucose Tolerance TestHumansInflammationInsulin ResistanceMaleMiddle Aged

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22409372

Citation

Marques-Vidal, Pedro, et al. "Association Between Circulating Cytokine Levels, Diabetes and Insulin Resistance in a Population-based Sample (CoLaus Study)." Clinical Endocrinology, vol. 78, no. 2, 2013, pp. 232-41.
Marques-Vidal P, Bastardot F, von Känel R, et al. Association between circulating cytokine levels, diabetes and insulin resistance in a population-based sample (CoLaus study). Clin Endocrinol (Oxf). 2013;78(2):232-41.
Marques-Vidal, P., Bastardot, F., von Känel, R., Paccaud, F., Preisig, M., Waeber, G., & Vollenweider, P. (2013). Association between circulating cytokine levels, diabetes and insulin resistance in a population-based sample (CoLaus study). Clinical Endocrinology, 78(2), 232-41. https://doi.org/10.1111/j.1365-2265.2012.04384.x
Marques-Vidal P, et al. Association Between Circulating Cytokine Levels, Diabetes and Insulin Resistance in a Population-based Sample (CoLaus Study). Clin Endocrinol (Oxf). 2013;78(2):232-41. PubMed PMID: 22409372.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between circulating cytokine levels, diabetes and insulin resistance in a population-based sample (CoLaus study). AU - Marques-Vidal,Pedro, AU - Bastardot,François, AU - von Känel,Roland, AU - Paccaud,Fred, AU - Preisig,Martin, AU - Waeber,Gérard, AU - Vollenweider,Peter, PY - 2011/12/21/received PY - 2012/01/18/revised PY - 2012/02/24/revised PY - 2012/03/07/accepted PY - 2012/3/14/entrez PY - 2012/3/14/pubmed PY - 2013/6/7/medline SP - 232 EP - 41 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 78 IS - 2 N2 - OBJECTIVE: The associations between inflammation, diabetes and insulin resistance remain controversial. Hence, we assessed the associations between diabetes, insulin resistance (using HOMA-IR) and metabolic syndrome with the inflammatory markers high-sensitive C-reactive protein (hs-CRP), interleukin-1 beta (IL-1β), interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α). DESIGN: Cross-sectional study. PARTICIPANTS: Two thousand eight hundred and eighty-four men and 3201 women, aged 35-75, participated in this study. METHODS: C-reactive protein was assessed by immunoassay and cytokines by multiplexed flow cytometric assay. In a subgroup of 532 participants, an oral glucose tolerance test (OGTT) was performed to screen for impaired glucose tolerance (IGT). RESULTS: IL-6, TNF-α and hs-CRP were significantly and positively correlated with fasting plasma glucose (FPG), insulin and HOMA-IR. Participants with diabetes had higher IL-6, TNF-α and hs-CRP levels than participants without diabetes; this difference persisted for hs-CRP after multivariate adjustment. Participants with metabolic syndrome had increased IL-6, TNF-α and hs-CRP levels; these differences persisted after multivariate adjustment. Participants in the highest quartile of HOMA-IR had increased IL-6, TNF-α and hs-CRP levels; these differences persisted for TNF-α and hs-CRP after multivariate adjustment. No association was found between IL-1β levels and all diabetes and insulin resistance markers studied. Finally, participants with IGT had higher hs-CRP levels than participants with a normal OGTT, but this difference disappeared after controlling for body mass index (BMI). CONCLUSION: We found that subjects with diabetes, metabolic syndrome and increased insulin resistance had increased levels of IL6, TNF-α and hs-CRP, while no association was found with IL-1β. The increased inflammatory state of subjects with IGT is partially explained by increased BMI. SN - 1365-2265 UR - https://www.unboundmedicine.com/medline/citation/22409372/Association_between_circulating_cytokine_levels_diabetes_and_insulin_resistance_in_a_population_based_sample__CoLaus_study__ L2 - https://doi.org/10.1111/j.1365-2265.2012.04384.x DB - PRIME DP - Unbound Medicine ER -