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[Trimetazidine versus betahistine in vestibular vertigo. A double blind study].
Ann Otolaryngol Chir Cervicofac. 1990; 107 Suppl 1:11-9.AO

Abstract

The efficacy of trimetazidine (60 mg/day) in vertigo was compared with that of betahistine (24 mg/day) in a three-month double-blind study. Included in the study were only patients with peripheral vertigo associated or not with tinnitus or hearing loss, and excluded were those presenting with symptoms related to retrocochlear or central disease. Out of the 40 patients enrolled, 20 suffered from Meniere's disease; 4 patients either dropped out of the study or were non-compliant to therapy and could not be taken into account in the final analysis, which bore on 36 patients (18 treated by trimetazidine and 18 with betahistine). There were no dropouts in the Meniere's disease subgroup (10 receiving trimetazidine and 10 receiving betahistine). Results revealed a better response to therapy with trimetazidine in patients suffering from vertigo, and this was particularly true of the Meniere's disease subgroup (p less than 0.025). Moreover, in the latter subgroup, all patients treated with trimetazidine fully recovered from vertigo spells, while these disappeared completely only in 4 of the patients administered betahistine (p less than 0.005). There was no noticeable difference between the two treatment groups as regards the evolution of the accompanying symptoms and the audiometric or vestibular test results. Clinical acceptability was equally excellent in both treatment groups. Overall, this study allowed to confirm the therapeutical efficacy of trimetazidine in the management of vertigo, as well as establishing the clinical advantage of trimetazidine over betahistine in patients suffering from Meniere's disease.

Authors+Show Affiliations

ENT Clinic, Ghent RUG.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
English Abstract
Journal Article

Language

fre

PubMed ID

2240994

Citation

Kluyskens, P, et al. "[Trimetazidine Versus Betahistine in Vestibular Vertigo. a Double Blind Study]." Annales D'oto-laryngologie Et De Chirurgie Cervico Faciale : Bulletin De La Societe D'oto-laryngologie Des Hopitaux De Paris, vol. 107 Suppl 1, 1990, pp. 11-9.
Kluyskens P, Lambert P, D'Hooge D. [Trimetazidine versus betahistine in vestibular vertigo. A double blind study]. Ann Otolaryngol Chir Cervicofac. 1990;107 Suppl 1:11-9.
Kluyskens, P., Lambert, P., & D'Hooge, D. (1990). [Trimetazidine versus betahistine in vestibular vertigo. A double blind study]. Annales D'oto-laryngologie Et De Chirurgie Cervico Faciale : Bulletin De La Societe D'oto-laryngologie Des Hopitaux De Paris, 107 Suppl 1, 11-9.
Kluyskens P, Lambert P, D'Hooge D. [Trimetazidine Versus Betahistine in Vestibular Vertigo. a Double Blind Study]. Ann Otolaryngol Chir Cervicofac. 1990;107 Suppl 1:11-9. PubMed PMID: 2240994.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Trimetazidine versus betahistine in vestibular vertigo. A double blind study]. AU - Kluyskens,P, AU - Lambert,P, AU - D'Hooge,D, PY - 1990/1/1/pubmed PY - 1990/1/1/medline PY - 1990/1/1/entrez SP - 11 EP - 9 JF - Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Societe d'oto-laryngologie des hopitaux de Paris JO - Ann Otolaryngol Chir Cervicofac VL - 107 Suppl 1 N2 - The efficacy of trimetazidine (60 mg/day) in vertigo was compared with that of betahistine (24 mg/day) in a three-month double-blind study. Included in the study were only patients with peripheral vertigo associated or not with tinnitus or hearing loss, and excluded were those presenting with symptoms related to retrocochlear or central disease. Out of the 40 patients enrolled, 20 suffered from Meniere's disease; 4 patients either dropped out of the study or were non-compliant to therapy and could not be taken into account in the final analysis, which bore on 36 patients (18 treated by trimetazidine and 18 with betahistine). There were no dropouts in the Meniere's disease subgroup (10 receiving trimetazidine and 10 receiving betahistine). Results revealed a better response to therapy with trimetazidine in patients suffering from vertigo, and this was particularly true of the Meniere's disease subgroup (p less than 0.025). Moreover, in the latter subgroup, all patients treated with trimetazidine fully recovered from vertigo spells, while these disappeared completely only in 4 of the patients administered betahistine (p less than 0.005). There was no noticeable difference between the two treatment groups as regards the evolution of the accompanying symptoms and the audiometric or vestibular test results. Clinical acceptability was equally excellent in both treatment groups. Overall, this study allowed to confirm the therapeutical efficacy of trimetazidine in the management of vertigo, as well as establishing the clinical advantage of trimetazidine over betahistine in patients suffering from Meniere's disease. SN - 0003-438X UR - https://www.unboundmedicine.com/medline/citation/2240994/[Trimetazidine_versus_betahistine_in_vestibular_vertigo__A_double_blind_study]_ L2 - https://medlineplus.gov/dizzinessandvertigo.html DB - PRIME DP - Unbound Medicine ER -