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Age-related changes in visual acuity, learning and memory in the APPswe/PS1dE9 mouse model of Alzheimer's disease.
Behav Brain Res. 2012 May 16; 231(1):75-85.BB

Abstract

Mouse models of Alzheimer's disease (AD) are often tested for learning and memory deficits using visuo-spatial tasks such as the Morris water maze. Performance on these tasks is dependent on vision and the APPswe/PS1dE9 mouse model has amyloid beta plaques in their retinas which might influence their performance in these tasks. In a visual learning task, old (20-26 months) transgenic mice and their wildtype littermates of both sexes had poorer visual ability than young (5-8 months) mice and old transgenic mice had poorer visual acuity than old wildtype mice. Old transgenic mice also had deficits in visuo-spatial learning and memory on the Morris water maze. The transgenic mice had no deficits in the conditioned odour preference or conditioned taste aversion memory tests at any age. These results indicate that the old APPswe/PS1dE9 mice and their wildtype littermates both have a deficit in their visual ability and that visually dependent measures alone should not be used to assess learning and memory in this strain.

Authors+Show Affiliations

Psychology Department and Neuroscience Institute, Dalhousie University, PO Box 1500, Halifax, NS B3H 4R2, Canada.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22409975

Citation

Stover, Kurt R., and Richard E. Brown. "Age-related Changes in Visual Acuity, Learning and Memory in the APPswe/PS1dE9 Mouse Model of Alzheimer's Disease." Behavioural Brain Research, vol. 231, no. 1, 2012, pp. 75-85.
Stover KR, Brown RE. Age-related changes in visual acuity, learning and memory in the APPswe/PS1dE9 mouse model of Alzheimer's disease. Behav Brain Res. 2012;231(1):75-85.
Stover, K. R., & Brown, R. E. (2012). Age-related changes in visual acuity, learning and memory in the APPswe/PS1dE9 mouse model of Alzheimer's disease. Behavioural Brain Research, 231(1), 75-85. https://doi.org/10.1016/j.bbr.2012.02.044
Stover KR, Brown RE. Age-related Changes in Visual Acuity, Learning and Memory in the APPswe/PS1dE9 Mouse Model of Alzheimer's Disease. Behav Brain Res. 2012 May 16;231(1):75-85. PubMed PMID: 22409975.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age-related changes in visual acuity, learning and memory in the APPswe/PS1dE9 mouse model of Alzheimer's disease. AU - Stover,Kurt R, AU - Brown,Richard E, Y1 - 2012/03/03/ PY - 2012/01/25/received PY - 2012/02/21/revised PY - 2012/02/25/accepted PY - 2012/3/14/entrez PY - 2012/3/14/pubmed PY - 2012/8/21/medline SP - 75 EP - 85 JF - Behavioural brain research JO - Behav. Brain Res. VL - 231 IS - 1 N2 - Mouse models of Alzheimer's disease (AD) are often tested for learning and memory deficits using visuo-spatial tasks such as the Morris water maze. Performance on these tasks is dependent on vision and the APPswe/PS1dE9 mouse model has amyloid beta plaques in their retinas which might influence their performance in these tasks. In a visual learning task, old (20-26 months) transgenic mice and their wildtype littermates of both sexes had poorer visual ability than young (5-8 months) mice and old transgenic mice had poorer visual acuity than old wildtype mice. Old transgenic mice also had deficits in visuo-spatial learning and memory on the Morris water maze. The transgenic mice had no deficits in the conditioned odour preference or conditioned taste aversion memory tests at any age. These results indicate that the old APPswe/PS1dE9 mice and their wildtype littermates both have a deficit in their visual ability and that visually dependent measures alone should not be used to assess learning and memory in this strain. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/22409975/Age_related_changes_in_visual_acuity_learning_and_memory_in_the_APPswe/PS1dE9_mouse_model_of_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(12)00173-8 DB - PRIME DP - Unbound Medicine ER -