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Sheep as a large animal model for middle and inner ear implantable hearing devices: a feasibility study in cadavers.
Otol Neurotol. 2012 Apr; 33(3):481-9.ON

Abstract

OBJECTIVE

Currently, no large animal model exists for surgical-experimental exploratory analysis of implantable hearing devices. In a histomorphometric study, we sought to investigate whether sheep or pig cochleae are suitable for this purpose and whether device implantation is feasible.

METHODS

Skulls of pig and sheep cadavers were examined using high-resolution 128-slice computed tomography (CT) to study anatomic relationships. A cochlear implant and an active middle ear implant could be successfully implanted into the sheep's inner and middle ear, respectively. Correct device placement was verified by CT and histology. The cochlear anatomy of the sheep was further studied by micro-CT and histology.

RESULTS

Our investigations indicate that the sheep is a suitable animal model for implantation of implantable hearing devices. The implantation of the devices was successfully performed by access through a mastoidectomy. The histologic, morphologic, and micro-CT study of the sheep cochlea showed that it is highly similar to the human cochlea. The temporal bone of the pig was not suitable for these microsurgical procedures because the middle and inner ear were not accessible owing to distinct soft and fatty tissue coverage of the mastoid.

CONCLUSION

The sheep is an appropriate large animal model for experimental studies with implantable hearing devices, whereas the pig is not.

Authors+Show Affiliations

Department of Otolaryngology, University Hospital, Medical University Innsbruck, Innsbruck, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22410732

Citation

Schnabl, Johannes, et al. "Sheep as a Large Animal Model for Middle and Inner Ear Implantable Hearing Devices: a Feasibility Study in Cadavers." Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, vol. 33, no. 3, 2012, pp. 481-9.
Schnabl J, Glueckert R, Feuchtner G, et al. Sheep as a large animal model for middle and inner ear implantable hearing devices: a feasibility study in cadavers. Otol Neurotol. 2012;33(3):481-9.
Schnabl, J., Glueckert, R., Feuchtner, G., Recheis, W., Potrusil, T., Kuhn, V., Wolf-Magele, A., Riechelmann, H., & Sprinzl, G. M. (2012). Sheep as a large animal model for middle and inner ear implantable hearing devices: a feasibility study in cadavers. Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 33(3), 481-9. https://doi.org/10.1097/MAO.0b013e318248ee3a
Schnabl J, et al. Sheep as a Large Animal Model for Middle and Inner Ear Implantable Hearing Devices: a Feasibility Study in Cadavers. Otol Neurotol. 2012;33(3):481-9. PubMed PMID: 22410732.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sheep as a large animal model for middle and inner ear implantable hearing devices: a feasibility study in cadavers. AU - Schnabl,Johannes, AU - Glueckert,Rudolf, AU - Feuchtner,Gudrun, AU - Recheis,Wolfgang, AU - Potrusil,Thomas, AU - Kuhn,Volker, AU - Wolf-Magele,Astrid, AU - Riechelmann,Herbert, AU - Sprinzl,Georg M, PY - 2012/3/14/entrez PY - 2012/3/14/pubmed PY - 2012/7/13/medline SP - 481 EP - 9 JF - Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology JO - Otol Neurotol VL - 33 IS - 3 N2 - OBJECTIVE: Currently, no large animal model exists for surgical-experimental exploratory analysis of implantable hearing devices. In a histomorphometric study, we sought to investigate whether sheep or pig cochleae are suitable for this purpose and whether device implantation is feasible. METHODS: Skulls of pig and sheep cadavers were examined using high-resolution 128-slice computed tomography (CT) to study anatomic relationships. A cochlear implant and an active middle ear implant could be successfully implanted into the sheep's inner and middle ear, respectively. Correct device placement was verified by CT and histology. The cochlear anatomy of the sheep was further studied by micro-CT and histology. RESULTS: Our investigations indicate that the sheep is a suitable animal model for implantation of implantable hearing devices. The implantation of the devices was successfully performed by access through a mastoidectomy. The histologic, morphologic, and micro-CT study of the sheep cochlea showed that it is highly similar to the human cochlea. The temporal bone of the pig was not suitable for these microsurgical procedures because the middle and inner ear were not accessible owing to distinct soft and fatty tissue coverage of the mastoid. CONCLUSION: The sheep is an appropriate large animal model for experimental studies with implantable hearing devices, whereas the pig is not. SN - 1537-4505 UR - https://www.unboundmedicine.com/medline/citation/22410732/Sheep_as_a_large_animal_model_for_middle_and_inner_ear_implantable_hearing_devices:_a_feasibility_study_in_cadavers_ L2 - https://doi.org/10.1097/MAO.0b013e318248ee3a DB - PRIME DP - Unbound Medicine ER -