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Vitamin D supplementation modulates blood and tissue zinc, liver glutathione and blood biochemical parameters in diabetic rats on a zinc-deficient diet.
Biol Trace Elem Res. 2012 Sep; 148(3):371-7.BT

Abstract

Previous studies suggest a protective effect of vitamin D3 on zinc deficiency-induced insulin secretion and on pancreas β-cell function. The aim of this study was to investigate the effect of vitamin D on blood biochemical parameters, tissue zinc and liver glutathione in diabetic rats fed a zinc-deficient diet. For that purpose, Alloxan-induced diabetic rats were divided into four groups. The first group was fed a zinc-sufficient diet while the second group was fed a zinc-deficient diet. The third and fourth groups received zinc-sufficient or zinc-deficient diets plus oral vitamin D3 for 27 days. At the end of the experiment, blood, femur, pancreas, kidney and liver samples were taken from all rats. The serum, femur, pancreas, kidney and liver zinc concentrations, liver glutathione, serum alkaline phosphatase activity, daily body weight gain and food intake were lower in the zinc-deficient rats in comparison with those receiving adequate amounts of zinc. These values were increased in the zinc-deficient group that was supplemented with vitamin D3. The serum total cholesterol, triglycerides, total protein, urea, glutamate oxaloacetate transaminase, glutamate pyruvate transaminase and blood glucose values were higher in rats fed a zinc adequate diet, but their concentrations were decreased by vitamin D3 supplementation. The serum total protein levels were not changed by zinc deficiency and vitamin D3 supplementation. These results suggest that vitamin D3 modulates tissue zinc, liver glutathione and blood biochemical values in diabetic rats fed a zinc-deficient diet.

Authors+Show Affiliations

Department of Biochemistry, Faculty of Sciences, University of Annaba, Annaba, Algeria. kechridzine@yahoo.frNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22410949

Citation

Kechrid, Zine, et al. "Vitamin D Supplementation Modulates Blood and Tissue Zinc, Liver Glutathione and Blood Biochemical Parameters in Diabetic Rats On a Zinc-deficient Diet." Biological Trace Element Research, vol. 148, no. 3, 2012, pp. 371-7.
Kechrid Z, Hamdi M, Naziroğlu M, et al. Vitamin D supplementation modulates blood and tissue zinc, liver glutathione and blood biochemical parameters in diabetic rats on a zinc-deficient diet. Biol Trace Elem Res. 2012;148(3):371-7.
Kechrid, Z., Hamdi, M., Naziroğlu, M., & Flores-Arce, M. (2012). Vitamin D supplementation modulates blood and tissue zinc, liver glutathione and blood biochemical parameters in diabetic rats on a zinc-deficient diet. Biological Trace Element Research, 148(3), 371-7. https://doi.org/10.1007/s12011-012-9383-z
Kechrid Z, et al. Vitamin D Supplementation Modulates Blood and Tissue Zinc, Liver Glutathione and Blood Biochemical Parameters in Diabetic Rats On a Zinc-deficient Diet. Biol Trace Elem Res. 2012;148(3):371-7. PubMed PMID: 22410949.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D supplementation modulates blood and tissue zinc, liver glutathione and blood biochemical parameters in diabetic rats on a zinc-deficient diet. AU - Kechrid,Zine, AU - Hamdi,Malika, AU - Naziroğlu,Mustafa, AU - Flores-Arce,Manuel, Y1 - 2012/03/14/ PY - 2012/02/01/received PY - 2012/02/28/accepted PY - 2012/3/14/entrez PY - 2012/3/14/pubmed PY - 2012/12/10/medline SP - 371 EP - 7 JF - Biological trace element research JO - Biol Trace Elem Res VL - 148 IS - 3 N2 - Previous studies suggest a protective effect of vitamin D3 on zinc deficiency-induced insulin secretion and on pancreas β-cell function. The aim of this study was to investigate the effect of vitamin D on blood biochemical parameters, tissue zinc and liver glutathione in diabetic rats fed a zinc-deficient diet. For that purpose, Alloxan-induced diabetic rats were divided into four groups. The first group was fed a zinc-sufficient diet while the second group was fed a zinc-deficient diet. The third and fourth groups received zinc-sufficient or zinc-deficient diets plus oral vitamin D3 for 27 days. At the end of the experiment, blood, femur, pancreas, kidney and liver samples were taken from all rats. The serum, femur, pancreas, kidney and liver zinc concentrations, liver glutathione, serum alkaline phosphatase activity, daily body weight gain and food intake were lower in the zinc-deficient rats in comparison with those receiving adequate amounts of zinc. These values were increased in the zinc-deficient group that was supplemented with vitamin D3. The serum total cholesterol, triglycerides, total protein, urea, glutamate oxaloacetate transaminase, glutamate pyruvate transaminase and blood glucose values were higher in rats fed a zinc adequate diet, but their concentrations were decreased by vitamin D3 supplementation. The serum total protein levels were not changed by zinc deficiency and vitamin D3 supplementation. These results suggest that vitamin D3 modulates tissue zinc, liver glutathione and blood biochemical values in diabetic rats fed a zinc-deficient diet. SN - 1559-0720 UR - https://www.unboundmedicine.com/medline/citation/22410949/Vitamin_D_supplementation_modulates_blood_and_tissue_zinc_liver_glutathione_and_blood_biochemical_parameters_in_diabetic_rats_on_a_zinc_deficient_diet_ L2 - https://dx.doi.org/10.1007/s12011-012-9383-z DB - PRIME DP - Unbound Medicine ER -