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Drug delivery in the nasal cavity after functional endoscopic sinus surgery: a computational fluid dynamics study.
J Laryngol Otol. 2012 May; 126(5):487-94.JL

Abstract

BACKGROUND

Intranasal medication is commonly used for nasal disease. However, there are no clear specifications for intranasal medication delivery after functional endoscopic sinus surgery.

METHODS

A three-dimensional model of the nasal cavity was constructed from computed tomography scans of an adult Chinese male who had previously undergone functional endoscopic sinus surgery in the right nasal cavity. Computational fluid dynamic simulations modelled airflow and particle deposition, based on discrete phase models.

RESULTS

In the right nasal cavity, more particles passed through the upper dorsal region, around the surgical area, and streamed into the right maxillary sinus region. In the left cavity, particles were distributed more regularly and uniformly in the ventral region around the inferior turbinate. A lower inspiratory airflow rate and smaller initial particle velocity assisted particle deposition within the right maxillary sinus cavity. In the right nasal cavity, the optimal particle diameter was approximately 10(-5) m for maxillary sinus cavity deposition and 3 × 10(-6) m for bottom region deposition. In the right nasal cavity, altered back head tilt angles enhanced particle deposition in the top region of the surgical area, and altered right side head tilt angles helped enhance maxillary sinus cavity deposition.

CONCLUSION

This model indicates that a moderate inspiratory airflow rate and a particle diameter of approximately 10(-5) m should improve intranasal medication deposition into the maxillary sinus cavity following functional endoscopic sinus surgery.

Links

Publisher Full Text

Authors+Show Affiliations

Chen XB
Department of Mechanical Engineering, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Lee HP
No affiliation info available
Chong VF
No affiliation info available
Wang DY
No affiliation info available

MeSH

Administration, IntranasalAdultAir MovementsDrug Delivery SystemsEndoscopyHumansHydrodynamicsImaging, Three-DimensionalInhalationMaleModels, BiologicalNasal CavityParanasal SinusesParticle SizePatient PositioningPostoperative PeriodRhinitisSinusitisTomography, X-Ray Computed

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22414292

Citation

Chen, X B., et al. "Drug Delivery in the Nasal Cavity After Functional Endoscopic Sinus Surgery: a Computational Fluid Dynamics Study." The Journal of Laryngology and Otology, vol. 126, no. 5, 2012, pp. 487-94.
Chen XB, Lee HP, Chong VF, et al. Drug delivery in the nasal cavity after functional endoscopic sinus surgery: a computational fluid dynamics study. J Laryngol Otol. 2012;126(5):487-94.
Chen, X. B., Lee, H. P., Chong, V. F., & Wang, D. Y. (2012). Drug delivery in the nasal cavity after functional endoscopic sinus surgery: a computational fluid dynamics study. The Journal of Laryngology and Otology, 126(5), 487-94. https://doi.org/10.1017/S0022215112000205
Chen XB, et al. Drug Delivery in the Nasal Cavity After Functional Endoscopic Sinus Surgery: a Computational Fluid Dynamics Study. J Laryngol Otol. 2012;126(5):487-94. PubMed PMID: 22414292.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Drug delivery in the nasal cavity after functional endoscopic sinus surgery: a computational fluid dynamics study. AU - Chen,X B, AU - Lee,H P, AU - Chong,V F H, AU - Wang,D Y, Y1 - 2012/03/14/ PY - 2012/3/15/entrez PY - 2012/3/15/pubmed PY - 2012/9/1/medline SP - 487 EP - 94 JF - The Journal of laryngology and otology JO - J Laryngol Otol VL - 126 IS - 5 N2 - BACKGROUND: Intranasal medication is commonly used for nasal disease. However, there are no clear specifications for intranasal medication delivery after functional endoscopic sinus surgery. METHODS: A three-dimensional model of the nasal cavity was constructed from computed tomography scans of an adult Chinese male who had previously undergone functional endoscopic sinus surgery in the right nasal cavity. Computational fluid dynamic simulations modelled airflow and particle deposition, based on discrete phase models. RESULTS: In the right nasal cavity, more particles passed through the upper dorsal region, around the surgical area, and streamed into the right maxillary sinus region. In the left cavity, particles were distributed more regularly and uniformly in the ventral region around the inferior turbinate. A lower inspiratory airflow rate and smaller initial particle velocity assisted particle deposition within the right maxillary sinus cavity. In the right nasal cavity, the optimal particle diameter was approximately 10(-5) m for maxillary sinus cavity deposition and 3 × 10(-6) m for bottom region deposition. In the right nasal cavity, altered back head tilt angles enhanced particle deposition in the top region of the surgical area, and altered right side head tilt angles helped enhance maxillary sinus cavity deposition. CONCLUSION: This model indicates that a moderate inspiratory airflow rate and a particle diameter of approximately 10(-5) m should improve intranasal medication deposition into the maxillary sinus cavity following functional endoscopic sinus surgery. SN - 1748-5460 UR - https://www.unboundmedicine.com/medline/citation/22414292/Drug_delivery_in_the_nasal_cavity_after_functional_endoscopic_sinus_surgery:_a_computational_fluid_dynamics_study_ L2 - https://www.cambridge.org/core/product/identifier/S0022215112000205/type/journal_article DB - PRIME DP - Unbound Medicine ER -