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Flavonoids as modulators of memory and learning: molecular interactions resulting in behavioural effects.
Proc Nutr Soc. 2012 May; 71(2):246-62.PN

Abstract

There is considerable interest in the potential of a group of dietary-derived phytochemicals known as flavonoids in modulating neuronal function and thereby influencing memory, learning and cognitive function. The present review begins by detailing the molecular events that underlie the acquisition and consolidation of new memories in the brain in order to provide a critical background to understanding the impact of flavonoid-rich diets or pure flavonoids on memory. Data suggests that despite limited brain bioavailability, dietary supplementation with flavonoid-rich foods, such as blueberry, green tea and Ginkgo biloba lead to significant reversals of age-related deficits on spatial memory and learning. Furthermore, animal and cellular studies suggest that the mechanisms underpinning their ability to induce improvements in memory are linked to the potential of absorbed flavonoids and their metabolites to interact with and modulate critical signalling pathways, transcription factors and gene and/or protein expression which control memory and learning processes in the hippocampus; the brain structure where spatial learning occurs. Overall, current evidence suggests that human translation of these animal investigations are warranted, as are further studies, to better understand the precise cause-and-effect relationship between flavonoid intake and cognitive outputs.

Authors+Show Affiliations

Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG6 6AP, UK.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22414320

Citation

Rendeiro, Catarina, et al. "Flavonoids as Modulators of Memory and Learning: Molecular Interactions Resulting in Behavioural Effects." The Proceedings of the Nutrition Society, vol. 71, no. 2, 2012, pp. 246-62.
Rendeiro C, Guerreiro JD, Williams CM, et al. Flavonoids as modulators of memory and learning: molecular interactions resulting in behavioural effects. Proc Nutr Soc. 2012;71(2):246-62.
Rendeiro, C., Guerreiro, J. D., Williams, C. M., & Spencer, J. P. (2012). Flavonoids as modulators of memory and learning: molecular interactions resulting in behavioural effects. The Proceedings of the Nutrition Society, 71(2), 246-62. https://doi.org/10.1017/S0029665112000146
Rendeiro C, et al. Flavonoids as Modulators of Memory and Learning: Molecular Interactions Resulting in Behavioural Effects. Proc Nutr Soc. 2012;71(2):246-62. PubMed PMID: 22414320.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Flavonoids as modulators of memory and learning: molecular interactions resulting in behavioural effects. AU - Rendeiro,Catarina, AU - Guerreiro,João D T, AU - Williams,Claire M, AU - Spencer,Jeremy P E, Y1 - 2012/03/14/ PY - 2012/3/15/entrez PY - 2012/3/15/pubmed PY - 2012/8/24/medline SP - 246 EP - 62 JF - The Proceedings of the Nutrition Society JO - Proc Nutr Soc VL - 71 IS - 2 N2 - There is considerable interest in the potential of a group of dietary-derived phytochemicals known as flavonoids in modulating neuronal function and thereby influencing memory, learning and cognitive function. The present review begins by detailing the molecular events that underlie the acquisition and consolidation of new memories in the brain in order to provide a critical background to understanding the impact of flavonoid-rich diets or pure flavonoids on memory. Data suggests that despite limited brain bioavailability, dietary supplementation with flavonoid-rich foods, such as blueberry, green tea and Ginkgo biloba lead to significant reversals of age-related deficits on spatial memory and learning. Furthermore, animal and cellular studies suggest that the mechanisms underpinning their ability to induce improvements in memory are linked to the potential of absorbed flavonoids and their metabolites to interact with and modulate critical signalling pathways, transcription factors and gene and/or protein expression which control memory and learning processes in the hippocampus; the brain structure where spatial learning occurs. Overall, current evidence suggests that human translation of these animal investigations are warranted, as are further studies, to better understand the precise cause-and-effect relationship between flavonoid intake and cognitive outputs. SN - 1475-2719 UR - https://www.unboundmedicine.com/medline/citation/22414320/Flavonoids_as_modulators_of_memory_and_learning:_molecular_interactions_resulting_in_behavioural_effects_ L2 - https://www.cambridge.org/core/product/identifier/S0029665112000146/type/journal_article DB - PRIME DP - Unbound Medicine ER -