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Sulfadiazine crystalluria revisited. The treatment of Toxoplasma encephalitis in patients with acquired immunodeficiency syndrome.
Arch Intern Med. 1990 Nov; 150(11):2379-84.AI

Abstract

Toxoplasma gondii encephalitis is an important opportunistic infection in the acquired immunodeficiency syndrome, estimated to occur in 20,000 to 40,000 patients with acquired immunodeficiency syndrome in the United States by 1991. The combination of sulfadiazine and pyrimethamine is regarded as the treatment of choice. Acute renal failure due to crystal deposition in the urinary tract was well described 30 to 40 years ago and is likely to resurface as a clinical entity if appropriate prophylactic measures are not taken. We describe two cases of sulfadiazine-induced crystalluria and renal failure in patients with acquired immunodeficiency syndrome, review the pertinent literature, and discuss the pathogenesis. Recommendations are made for the prophylaxis and treatment of sulfadiazine-related renal toxic reaction. Physicians using this "new" drug must be aware of the potential danger of sulfonamide-induced injury to the urinary tract.

Authors+Show Affiliations

Department of Medicine, Beth Israel Hospital, Boston, Mass.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

2241449

Citation

Simon, D I., et al. "Sulfadiazine Crystalluria Revisited. the Treatment of Toxoplasma Encephalitis in Patients With Acquired Immunodeficiency Syndrome." Archives of Internal Medicine, vol. 150, no. 11, 1990, pp. 2379-84.
Simon DI, Brosius FC, Rothstein DM. Sulfadiazine crystalluria revisited. The treatment of Toxoplasma encephalitis in patients with acquired immunodeficiency syndrome. Arch Intern Med. 1990;150(11):2379-84.
Simon, D. I., Brosius, F. C., & Rothstein, D. M. (1990). Sulfadiazine crystalluria revisited. The treatment of Toxoplasma encephalitis in patients with acquired immunodeficiency syndrome. Archives of Internal Medicine, 150(11), 2379-84.
Simon DI, Brosius FC, Rothstein DM. Sulfadiazine Crystalluria Revisited. the Treatment of Toxoplasma Encephalitis in Patients With Acquired Immunodeficiency Syndrome. Arch Intern Med. 1990;150(11):2379-84. PubMed PMID: 2241449.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sulfadiazine crystalluria revisited. The treatment of Toxoplasma encephalitis in patients with acquired immunodeficiency syndrome. AU - Simon,D I, AU - Brosius,F C,3rd AU - Rothstein,D M, PY - 1990/11/1/pubmed PY - 1990/11/1/medline PY - 1990/11/1/entrez SP - 2379 EP - 84 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 150 IS - 11 N2 - Toxoplasma gondii encephalitis is an important opportunistic infection in the acquired immunodeficiency syndrome, estimated to occur in 20,000 to 40,000 patients with acquired immunodeficiency syndrome in the United States by 1991. The combination of sulfadiazine and pyrimethamine is regarded as the treatment of choice. Acute renal failure due to crystal deposition in the urinary tract was well described 30 to 40 years ago and is likely to resurface as a clinical entity if appropriate prophylactic measures are not taken. We describe two cases of sulfadiazine-induced crystalluria and renal failure in patients with acquired immunodeficiency syndrome, review the pertinent literature, and discuss the pathogenesis. Recommendations are made for the prophylaxis and treatment of sulfadiazine-related renal toxic reaction. Physicians using this "new" drug must be aware of the potential danger of sulfonamide-induced injury to the urinary tract. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/2241449/Sulfadiazine_crystalluria_revisited__The_treatment_of_Toxoplasma_encephalitis_in_patients_with_acquired_immunodeficiency_syndrome_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/150/pg/2379 DB - PRIME DP - Unbound Medicine ER -