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The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model.
Anesth Analg. 2012 Jul; 115(1):182-8.A&A

Abstract

BACKGROUND

It has been reported that <50% of neuropathic pain patients are satisfactorily treated with drugs. It is possible that this lack of efficacy of drugs on neuropathic pain might be due to the drugs prescribed, regardless of the origin of pain. We compared the efficacy of orally administered morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia with that on neuroma pain using the tibial neuroma transposition (TNT) model.

METHODS

In the TNT model, the tibial nerve is transected, and the tibial nerve stump is transpositioned to the lateral aspect of the hindlimb. After TNT injury, mechanical allodynia and neuroma pain are observed. Morphine, pregabalin, gabapentin, and duloxetine were administered orally and were examined for the antiallodynic and antineuroma pain effects.

RESULTS

Morphine, pregabalin, gabapentin, and duloxetine attenuated the level of mechanical allodynia in a dose-dependent manner. Morphine-but not pregabalin, gabapentin, and duloxetine-attenuated the neuroma pain. Morphine was less potent in neuroma pain than in mechanical allodynia. In the 2-drug-combination studies (morphine + pregabalin, morphine + duloxetine, and pregabalin + duloxetine), all drug combinations produced a synergistic effect on mechanical allodynia, but not on neuroma pain.

CONCLUSIONS

These data indicate that the potency of morphine and the efficacy of pregabalin, gabapentin, and duloxetine on mechanical allodynia are different from those on neuroma pain and that combination therapy is one of different therapeutic choices for the treatment of neuropathic pain.

Authors+Show Affiliations

Department of Anesthesiology, School of Medical Science, Kumamoto University, 1-1-1 Honjo, Kumamoto-shi, Kumamoto 860-8556, Japan.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22415534

Citation

Miyazaki, Rika, and Tatsuo Yamamoto. "The Efficacy of Morphine, Pregabalin, Gabapentin, and Duloxetine On Mechanical Allodynia Is Different From That On Neuroma Pain in the Rat Neuropathic Pain Model." Anesthesia and Analgesia, vol. 115, no. 1, 2012, pp. 182-8.
Miyazaki R, Yamamoto T. The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model. Anesth Analg. 2012;115(1):182-8.
Miyazaki, R., & Yamamoto, T. (2012). The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model. Anesthesia and Analgesia, 115(1), 182-8. https://doi.org/10.1213/ANE.0b013e31824f94ca
Miyazaki R, Yamamoto T. The Efficacy of Morphine, Pregabalin, Gabapentin, and Duloxetine On Mechanical Allodynia Is Different From That On Neuroma Pain in the Rat Neuropathic Pain Model. Anesth Analg. 2012;115(1):182-8. PubMed PMID: 22415534.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model. AU - Miyazaki,Rika, AU - Yamamoto,Tatsuo, Y1 - 2012/03/13/ PY - 2012/3/15/entrez PY - 2012/3/15/pubmed PY - 2012/9/1/medline SP - 182 EP - 8 JF - Anesthesia and analgesia JO - Anesth Analg VL - 115 IS - 1 N2 - BACKGROUND: It has been reported that <50% of neuropathic pain patients are satisfactorily treated with drugs. It is possible that this lack of efficacy of drugs on neuropathic pain might be due to the drugs prescribed, regardless of the origin of pain. We compared the efficacy of orally administered morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia with that on neuroma pain using the tibial neuroma transposition (TNT) model. METHODS: In the TNT model, the tibial nerve is transected, and the tibial nerve stump is transpositioned to the lateral aspect of the hindlimb. After TNT injury, mechanical allodynia and neuroma pain are observed. Morphine, pregabalin, gabapentin, and duloxetine were administered orally and were examined for the antiallodynic and antineuroma pain effects. RESULTS: Morphine, pregabalin, gabapentin, and duloxetine attenuated the level of mechanical allodynia in a dose-dependent manner. Morphine-but not pregabalin, gabapentin, and duloxetine-attenuated the neuroma pain. Morphine was less potent in neuroma pain than in mechanical allodynia. In the 2-drug-combination studies (morphine + pregabalin, morphine + duloxetine, and pregabalin + duloxetine), all drug combinations produced a synergistic effect on mechanical allodynia, but not on neuroma pain. CONCLUSIONS: These data indicate that the potency of morphine and the efficacy of pregabalin, gabapentin, and duloxetine on mechanical allodynia are different from those on neuroma pain and that combination therapy is one of different therapeutic choices for the treatment of neuropathic pain. SN - 1526-7598 UR - https://www.unboundmedicine.com/medline/citation/22415534/The_efficacy_of_morphine_pregabalin_gabapentin_and_duloxetine_on_mechanical_allodynia_is_different_from_that_on_neuroma_pain_in_the_rat_neuropathic_pain_model_ L2 - https://doi.org/10.1213/ANE.0b013e31824f94ca DB - PRIME DP - Unbound Medicine ER -