Tags

Type your tag names separated by a space and hit enter

Exercise training attenuates neuropathic pain and cytokine expression after chronic constriction injury of rat sciatic nerve.
Anesth Analg. 2012 Jun; 114(6):1330-7.A&A

Abstract

BACKGROUND

The underlying mechanism of exercise on neuropathic pain is not well understood. We investigated whether physical exercise regulates the functional recovery and heat shock protein 72 (Hsp72), tumor necrosis factor-α (TNF-α), and interlukin-1β (IL-1β) expression after chronic constriction injury (CCI) of the sciatic nerve.

METHODS

Male Sprague-Dawley rats were divided into 7 groups: control, sham operated (SO), SO with swimming or treadmill exercise (SOSE or SOTE), CCI, CCI with swimming or treadmill exercise (CCISE or CCITE). We recorded body weight, thermal withdrawal latency, and mechanical withdrawal threshold as well as Hsp72, TNF-α, and IL-1β expression in sciatic nerve.

RESULTS

The body weights in the control and SO groups were heavier than those in the SOSE, SOTE, CCI, CCISE, and CCITE groups. CCI rats with swimming or treadmill exercise showed significant increase in thermal withdrawal latency and mechanical withdrawal threshold when compared with CCI rats without exercise on day 21 after CCI. Both CCISE and CCITE groups demonstrated greater Hsp72 expression and lower TNF-α or IL-1β level than did the CCI group in sciatic nerve on day 21 after CCI.

CONCLUSIONS

These results suggest that progressive exercise training decreases peripheral neuropathic pain as well as TNF-α and IL-1β overproduction and increases HSP72 expression after CCI of the sciatic nerve.

Authors+Show Affiliations

Department of Physical Therapy, China Medical University, Taichung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22415536

Citation

Chen, Yu-Wen, et al. "Exercise Training Attenuates Neuropathic Pain and Cytokine Expression After Chronic Constriction Injury of Rat Sciatic Nerve." Anesthesia and Analgesia, vol. 114, no. 6, 2012, pp. 1330-7.
Chen YW, Li YT, Chen YC, et al. Exercise training attenuates neuropathic pain and cytokine expression after chronic constriction injury of rat sciatic nerve. Anesth Analg. 2012;114(6):1330-7.
Chen, Y. W., Li, Y. T., Chen, Y. C., Li, Z. Y., & Hung, C. H. (2012). Exercise training attenuates neuropathic pain and cytokine expression after chronic constriction injury of rat sciatic nerve. Anesthesia and Analgesia, 114(6), 1330-7. https://doi.org/10.1213/ANE.0b013e31824c4ed4
Chen YW, et al. Exercise Training Attenuates Neuropathic Pain and Cytokine Expression After Chronic Constriction Injury of Rat Sciatic Nerve. Anesth Analg. 2012;114(6):1330-7. PubMed PMID: 22415536.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exercise training attenuates neuropathic pain and cytokine expression after chronic constriction injury of rat sciatic nerve. AU - Chen,Yu-Wen, AU - Li,Yung-Tsung, AU - Chen,Yu Chung, AU - Li,Zong-Ying, AU - Hung,Ching-Hsia, Y1 - 2012/03/13/ PY - 2012/3/15/entrez PY - 2012/3/15/pubmed PY - 2012/7/20/medline SP - 1330 EP - 7 JF - Anesthesia and analgesia JO - Anesth Analg VL - 114 IS - 6 N2 - BACKGROUND: The underlying mechanism of exercise on neuropathic pain is not well understood. We investigated whether physical exercise regulates the functional recovery and heat shock protein 72 (Hsp72), tumor necrosis factor-α (TNF-α), and interlukin-1β (IL-1β) expression after chronic constriction injury (CCI) of the sciatic nerve. METHODS: Male Sprague-Dawley rats were divided into 7 groups: control, sham operated (SO), SO with swimming or treadmill exercise (SOSE or SOTE), CCI, CCI with swimming or treadmill exercise (CCISE or CCITE). We recorded body weight, thermal withdrawal latency, and mechanical withdrawal threshold as well as Hsp72, TNF-α, and IL-1β expression in sciatic nerve. RESULTS: The body weights in the control and SO groups were heavier than those in the SOSE, SOTE, CCI, CCISE, and CCITE groups. CCI rats with swimming or treadmill exercise showed significant increase in thermal withdrawal latency and mechanical withdrawal threshold when compared with CCI rats without exercise on day 21 after CCI. Both CCISE and CCITE groups demonstrated greater Hsp72 expression and lower TNF-α or IL-1β level than did the CCI group in sciatic nerve on day 21 after CCI. CONCLUSIONS: These results suggest that progressive exercise training decreases peripheral neuropathic pain as well as TNF-α and IL-1β overproduction and increases HSP72 expression after CCI of the sciatic nerve. SN - 1526-7598 UR - https://www.unboundmedicine.com/medline/citation/22415536/Exercise_training_attenuates_neuropathic_pain_and_cytokine_expression_after_chronic_constriction_injury_of_rat_sciatic_nerve_ L2 - https://doi.org/10.1213/ANE.0b013e31824c4ed4 DB - PRIME DP - Unbound Medicine ER -