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Diagnostic value of serum activin A and follistatin levels in women with peritoneal, ovarian and deep infiltrating endometriosis.
Hum Reprod. 2012 May; 27(5):1445-50.HR

Abstract

BACKGROUND

Activin A is a growth factor, produced by the endometrium, whose actions are modulated by the binding protein follistatin. Both proteins are detectable in the peripheral serum and their concentrations may be increased in women with endometriosis. The present study was designed to evaluate whether serum levels of activin A and follistatin are altered, and therefore have a potential diagnostic value, in women with peritoneal, ovarian and deep infiltrating endometriosis.

METHODS

We performed a multicenter controlled study evaluating simultaneously serum activin A and follistatin concentrations in women with and without endometriosis. Women with endometriosis (n = 139) were subdivided into three groups: peritoneal endometriosis (n = 28); ovarian endometrioma (n = 61) and deep infiltrating endometriosis (n = 50). The control group (n = 75) consisted of healthy women with regular menstrual cycles. Blood samples were collected from a peripheral vein and assayed for activin A and follistatin using commercially available enzyme immunoassay kits.

RESULTS

The ovarian endometrioma group had serum activin A levels significantly higher than healthy controls (0.22 ± 0.01 ng/ml versus 0.17 ± 0.01 ng/ml, P < 0.01). None of the endometriosis groups had serum follistatin levels which were significantly altered compared with healthy controls; however, levels found in the endometrioma group (2.34 ± 0.32 ng/ml) were higher than that in the deep endometriosis group (1.50 ± 0.17 ng/ml, P < 0.05). The area under the receiver operating characteristic curve of activin A was 0.700 (95% confidence interval: 0.605-0.794), while that of follistatin was 0.620 (95% confidence interval: 0.510-0.730) for the diagnosis of ovarian endometrioma. The combination of both markers into a duo marker index did not improve significantly their diagnostic accuracy.

CONCLUSIONS

The present study demonstrated that serum activin A and follistatin are not significantly altered in peritoneal or deep infiltrating endometriosis and have limited diagnostic accuracy in the diagnosis of ovarian endometrioma.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, University of Minas Gerais, and National Institute of Hormones and Women's Health, Belo Horizonte, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22416010

Citation

Reis, Fernando M., et al. "Diagnostic Value of Serum Activin a and Follistatin Levels in Women With Peritoneal, Ovarian and Deep Infiltrating Endometriosis." Human Reproduction (Oxford, England), vol. 27, no. 5, 2012, pp. 1445-50.
Reis FM, Luisi S, Abrão MS, et al. Diagnostic value of serum activin A and follistatin levels in women with peritoneal, ovarian and deep infiltrating endometriosis. Hum Reprod. 2012;27(5):1445-50.
Reis, F. M., Luisi, S., Abrão, M. S., Rocha, A. L., Viganò, P., Rezende, C. P., Florio, P., & Petraglia, F. (2012). Diagnostic value of serum activin A and follistatin levels in women with peritoneal, ovarian and deep infiltrating endometriosis. Human Reproduction (Oxford, England), 27(5), 1445-50. https://doi.org/10.1093/humrep/des055
Reis FM, et al. Diagnostic Value of Serum Activin a and Follistatin Levels in Women With Peritoneal, Ovarian and Deep Infiltrating Endometriosis. Hum Reprod. 2012;27(5):1445-50. PubMed PMID: 22416010.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnostic value of serum activin A and follistatin levels in women with peritoneal, ovarian and deep infiltrating endometriosis. AU - Reis,Fernando M, AU - Luisi,Stefano, AU - Abrão,Maurício S, AU - Rocha,Ana Luiza L, AU - Viganò,Paola, AU - Rezende,Carolina P, AU - Florio,Pasquale, AU - Petraglia,Felice, Y1 - 2012/03/12/ PY - 2012/3/15/entrez PY - 2012/3/15/pubmed PY - 2013/1/29/medline SP - 1445 EP - 50 JF - Human reproduction (Oxford, England) JO - Hum. Reprod. VL - 27 IS - 5 N2 - BACKGROUND: Activin A is a growth factor, produced by the endometrium, whose actions are modulated by the binding protein follistatin. Both proteins are detectable in the peripheral serum and their concentrations may be increased in women with endometriosis. The present study was designed to evaluate whether serum levels of activin A and follistatin are altered, and therefore have a potential diagnostic value, in women with peritoneal, ovarian and deep infiltrating endometriosis. METHODS: We performed a multicenter controlled study evaluating simultaneously serum activin A and follistatin concentrations in women with and without endometriosis. Women with endometriosis (n = 139) were subdivided into three groups: peritoneal endometriosis (n = 28); ovarian endometrioma (n = 61) and deep infiltrating endometriosis (n = 50). The control group (n = 75) consisted of healthy women with regular menstrual cycles. Blood samples were collected from a peripheral vein and assayed for activin A and follistatin using commercially available enzyme immunoassay kits. RESULTS: The ovarian endometrioma group had serum activin A levels significantly higher than healthy controls (0.22 ± 0.01 ng/ml versus 0.17 ± 0.01 ng/ml, P < 0.01). None of the endometriosis groups had serum follistatin levels which were significantly altered compared with healthy controls; however, levels found in the endometrioma group (2.34 ± 0.32 ng/ml) were higher than that in the deep endometriosis group (1.50 ± 0.17 ng/ml, P < 0.05). The area under the receiver operating characteristic curve of activin A was 0.700 (95% confidence interval: 0.605-0.794), while that of follistatin was 0.620 (95% confidence interval: 0.510-0.730) for the diagnosis of ovarian endometrioma. The combination of both markers into a duo marker index did not improve significantly their diagnostic accuracy. CONCLUSIONS: The present study demonstrated that serum activin A and follistatin are not significantly altered in peritoneal or deep infiltrating endometriosis and have limited diagnostic accuracy in the diagnosis of ovarian endometrioma. SN - 1460-2350 UR - https://www.unboundmedicine.com/medline/citation/22416010/Diagnostic_value_of_serum_activin_A_and_follistatin_levels_in_women_with_peritoneal_ovarian_and_deep_infiltrating_endometriosis_ L2 - https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/des055 DB - PRIME DP - Unbound Medicine ER -