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Growing pains: twin family study evidence for genetic susceptibility and a genetic relationship with restless legs syndrome.
Eur J Pain 2012; 16(9):1224-31EJ

Abstract

BACKGROUND

Growing pains (GP) is a prevalent familial childhood disorder of unknown aetiology. Familial occurrence of GP, and individual and familial association of GP with restless legs syndrome (RLS) has been reported.

METHODS

We applied a twin family design to search for evidence of genetic susceptibility to GP, and for a genetic relationship between GP and RLS. The parents of 1843 twin pairs aged 3-16 years were administered a questionnaire, which identified 88 pairs with at least one twin individual fulfilling criteria for GP. Standard questionnaires for history of GP and RLS were completed for these twin pairs, their siblings and parents.

RESULTS

Twenty-five of 34 monozygotic (MZ) pairs were concordant for GP, compared with 12 of the 54 dizygotic (DZ) pairs. The casewise concordance was 0.85 and 0.36 for MZ and DZ pairs, respectively (p < 0.001). The lifetime GP prevalence for relatives of twins with GP was 51% for non-twin siblings, 47% for parents. Twenty-three percent of twin individuals with GP met RLS criteria compared with 8% of twin individuals without GP (p = 0.03). Of the twins with GP concordance, 19% met RLS criteria compared with 2% of twins with GP discordance (p = 0.01). In two MZ pairs, one had GP and the other RLS. The lifetime prevalence of RLS was 40% for mothers, and 24% for fathers and 18% for non-twin siblings.

CONCLUSION

This first twin family study of GP provides evidence for a genetic aetiology and for a genetic relationship to RLS.

Authors+Show Affiliations

Department of Anaesthesia and Pain Medicine, Sydney Children's Hospital, Randwick, Australia. dchamp@bigpond.net.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Twin Study

Language

eng

PubMed ID

22416025

Citation

Champion, D, et al. "Growing Pains: Twin Family Study Evidence for Genetic Susceptibility and a Genetic Relationship With Restless Legs Syndrome." European Journal of Pain (London, England), vol. 16, no. 9, 2012, pp. 1224-31.
Champion D, Pathirana S, Flynn C, et al. Growing pains: twin family study evidence for genetic susceptibility and a genetic relationship with restless legs syndrome. Eur J Pain. 2012;16(9):1224-31.
Champion, D., Pathirana, S., Flynn, C., Taylor, A., Hopper, J. L., Berkovic, S. F., ... Qiu, W. (2012). Growing pains: twin family study evidence for genetic susceptibility and a genetic relationship with restless legs syndrome. European Journal of Pain (London, England), 16(9), pp. 1224-31. doi:10.1002/j.1532-2149.2012.00130.x.
Champion D, et al. Growing Pains: Twin Family Study Evidence for Genetic Susceptibility and a Genetic Relationship With Restless Legs Syndrome. Eur J Pain. 2012;16(9):1224-31. PubMed PMID: 22416025.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Growing pains: twin family study evidence for genetic susceptibility and a genetic relationship with restless legs syndrome. AU - Champion,D, AU - Pathirana,S, AU - Flynn,C, AU - Taylor,A, AU - Hopper,J L, AU - Berkovic,S F, AU - Jaaniste,T, AU - Qiu,W, Y1 - 2012/03/13/ PY - 2012/02/10/accepted PY - 2012/3/15/entrez PY - 2012/3/15/pubmed PY - 2013/1/26/medline SP - 1224 EP - 31 JF - European journal of pain (London, England) JO - Eur J Pain VL - 16 IS - 9 N2 - BACKGROUND: Growing pains (GP) is a prevalent familial childhood disorder of unknown aetiology. Familial occurrence of GP, and individual and familial association of GP with restless legs syndrome (RLS) has been reported. METHODS: We applied a twin family design to search for evidence of genetic susceptibility to GP, and for a genetic relationship between GP and RLS. The parents of 1843 twin pairs aged 3-16 years were administered a questionnaire, which identified 88 pairs with at least one twin individual fulfilling criteria for GP. Standard questionnaires for history of GP and RLS were completed for these twin pairs, their siblings and parents. RESULTS: Twenty-five of 34 monozygotic (MZ) pairs were concordant for GP, compared with 12 of the 54 dizygotic (DZ) pairs. The casewise concordance was 0.85 and 0.36 for MZ and DZ pairs, respectively (p < 0.001). The lifetime GP prevalence for relatives of twins with GP was 51% for non-twin siblings, 47% for parents. Twenty-three percent of twin individuals with GP met RLS criteria compared with 8% of twin individuals without GP (p = 0.03). Of the twins with GP concordance, 19% met RLS criteria compared with 2% of twins with GP discordance (p = 0.01). In two MZ pairs, one had GP and the other RLS. The lifetime prevalence of RLS was 40% for mothers, and 24% for fathers and 18% for non-twin siblings. CONCLUSION: This first twin family study of GP provides evidence for a genetic aetiology and for a genetic relationship to RLS. SN - 1532-2149 UR - https://www.unboundmedicine.com/medline/citation/22416025/Growing_pains:_twin_family_study_evidence_for_genetic_susceptibility_and_a_genetic_relationship_with_restless_legs_syndrome_ L2 - https://doi.org/10.1002/j.1532-2149.2012.00130.x DB - PRIME DP - Unbound Medicine ER -