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The value of diffusion tensor imaging in the differential diagnosis of subcortical ischemic vascular dementia and Alzheimer's disease in patients with only mild white matter alterations on T2-weighted images.
Acta Radiol. 2012 Apr 01; 53(3):312-7.AR

Abstract

BACKGROUND

Diffusion tensor imaging (DTI) is a form of functional magnetic resonance imaging (MRI) that allows examination of the microstructural integrity of white matter in the brain. Dementia is a neurodegenerative disease, and DTI can provide indirect insights of the microstructural characteristics of brains in individuals with different forms of dementia.

PURPOSE

To evaluate the value of DTI in the diagnosis and differential diagnosis of patients with subcortical ischemic vascular dementia (SIVD) and Alzheimer's disease (AD).

MATERIAL AND METHODS

The study included 40 patients (20 AD patients and 20 SIVD patients) and 20 normal controls (NC). After routine MRI and DTI, fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values were measured and compared in regions of interest (ROI).

RESULTS

Compared to NC and AD patients, SIVD patients had lower FA values and higher ADC values in the inferior-fronto-occipital fascicles (IFOF), genu of the corpus callosum (GCC), splenium of the corpus callosum (SCC), and superior longitudinal fasciculus (SLF). Compared to controls and SIVD patients, AD patients had lower FA values in the anterior frontal lobe, temporal lobe, hippocampus, IFOF, GCC, and CF; and higher ADC values in the temporal lobe and hippocampus.

CONCLUSION

DTI can be used to estimate the white matter impairment in dementia patients. There were significant regional reductions of FA values and heightened ADC values in multiple regions in SIVD patients compared to AD patients. When compared with conventional MRI, DTI may provide a more objective method for the differential diagnosis of SIVD and AD disease patients who have only mild white matter alterations on T2-weighted imaging.

Authors+Show Affiliations

Department of Neurology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22416261

Citation

Fu, Jian-Liang, et al. "The Value of Diffusion Tensor Imaging in the Differential Diagnosis of Subcortical Ischemic Vascular Dementia and Alzheimer's Disease in Patients With Only Mild White Matter Alterations On T2-weighted Images." Acta Radiologica (Stockholm, Sweden : 1987), vol. 53, no. 3, 2012, pp. 312-7.
Fu JL, Zhang T, Chang C, et al. The value of diffusion tensor imaging in the differential diagnosis of subcortical ischemic vascular dementia and Alzheimer's disease in patients with only mild white matter alterations on T2-weighted images. Acta Radiol. 2012;53(3):312-7.
Fu, J. L., Zhang, T., Chang, C., Zhang, Y. Z., & Li, W. B. (2012). The value of diffusion tensor imaging in the differential diagnosis of subcortical ischemic vascular dementia and Alzheimer's disease in patients with only mild white matter alterations on T2-weighted images. Acta Radiologica (Stockholm, Sweden : 1987), 53(3), 312-7. https://doi.org/10.1258/ar.2011.110272
Fu JL, et al. The Value of Diffusion Tensor Imaging in the Differential Diagnosis of Subcortical Ischemic Vascular Dementia and Alzheimer's Disease in Patients With Only Mild White Matter Alterations On T2-weighted Images. Acta Radiol. 2012 Apr 1;53(3):312-7. PubMed PMID: 22416261.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The value of diffusion tensor imaging in the differential diagnosis of subcortical ischemic vascular dementia and Alzheimer's disease in patients with only mild white matter alterations on T2-weighted images. AU - Fu,Jian-Liang, AU - Zhang,Ting, AU - Chang,Cheng, AU - Zhang,Yu-Zhen, AU - Li,Wen-Bin, Y1 - 2012/03/13/ PY - 2012/3/15/entrez PY - 2012/3/15/pubmed PY - 2012/6/5/medline SP - 312 EP - 7 JF - Acta radiologica (Stockholm, Sweden : 1987) JO - Acta Radiol VL - 53 IS - 3 N2 - BACKGROUND: Diffusion tensor imaging (DTI) is a form of functional magnetic resonance imaging (MRI) that allows examination of the microstructural integrity of white matter in the brain. Dementia is a neurodegenerative disease, and DTI can provide indirect insights of the microstructural characteristics of brains in individuals with different forms of dementia. PURPOSE: To evaluate the value of DTI in the diagnosis and differential diagnosis of patients with subcortical ischemic vascular dementia (SIVD) and Alzheimer's disease (AD). MATERIAL AND METHODS: The study included 40 patients (20 AD patients and 20 SIVD patients) and 20 normal controls (NC). After routine MRI and DTI, fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values were measured and compared in regions of interest (ROI). RESULTS: Compared to NC and AD patients, SIVD patients had lower FA values and higher ADC values in the inferior-fronto-occipital fascicles (IFOF), genu of the corpus callosum (GCC), splenium of the corpus callosum (SCC), and superior longitudinal fasciculus (SLF). Compared to controls and SIVD patients, AD patients had lower FA values in the anterior frontal lobe, temporal lobe, hippocampus, IFOF, GCC, and CF; and higher ADC values in the temporal lobe and hippocampus. CONCLUSION: DTI can be used to estimate the white matter impairment in dementia patients. There were significant regional reductions of FA values and heightened ADC values in multiple regions in SIVD patients compared to AD patients. When compared with conventional MRI, DTI may provide a more objective method for the differential diagnosis of SIVD and AD disease patients who have only mild white matter alterations on T2-weighted imaging. SN - 1600-0455 UR - https://www.unboundmedicine.com/medline/citation/22416261/The_value_of_diffusion_tensor_imaging_in_the_differential_diagnosis_of_subcortical_ischemic_vascular_dementia_and_Alzheimer's_disease_in_patients_with_only_mild_white_matter_alterations_on_T2_weighted_images_ L2 - http://journals.sagepub.com/doi/full/10.1258/ar.2011.110272?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -