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Inhibitory effects of various essential oils and individual components against extended-spectrum beta-lactamase (ESBL) produced by Klebsiella pneumoniae and their chemical compositions.
J Food Sci. 2011 Oct; 76(8):M538-46.JF

Abstract

In the current study, in vitro inhibitory activity of several essential oils obtained from the cultivated plants, Foeniculum vulgare, Mentha piperita and M. spicata, Ocimum basilicum, Origanum majorana, O. onites, O. vulgare, Satureja cuneifolia, and a number of individual essential oil components of terpene and aromatic types were screened against 10 isolated strains of Klebsiella pneumoniae producing extended-spectrum beta-lactamase (ESBL) enzyme, which makes this microorganism quite resistant against the antibiotics: trimetoprime-sulfametoksazol, sulbactam-ampicilin, clavulonate-amoxicilin, ceftriaxon, cefepime, imipenem, ceftazidime, tobramicine, gentamisine, ofloxacin, and ciprofloksasin. All of the essential oils and the components exerted a remarkable inhibition ranging between 32 and 64 μg/mL against all of these strains as strong as the references (ampicilin and oflaxocin) inhibiting at 32 μg/mL. Besides, chemical compositions of the essential oils were elucidated by gas chromatography-mass spectrometry (GC-MS). The essential oils and the pure components widely found in essential oils screened herein have shown remarkable inhibition against ESBL-producing K. pneumoniae strains, which leads to the suggestion that they may be used as food preservatives for this purpose. Practical Application: The essential oils obtained from Foeniculum vulgare, Mentha piperita and M. spicata, O.cimum basilicum, Origanum majorana, O. onites, O. vulgare, and Satureja cuneifolia as well as common essential oil components have shown notable inhibitory effects against 10 isolated strains of Klebsiella pneumoniae producing extended-spectrum beta-lactamase (ESBL) enzyme and they might be used as food preservative or ingredient.

Authors+Show Affiliations

Dept. of Pharmacognosy, Faculty of Pharmacy, Gazi Univ., 06330 Ankara, Turkey. iorhan@gazi.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22417594

Citation

Orhan, Ilkay Erdogan, et al. "Inhibitory Effects of Various Essential Oils and Individual Components Against Extended-spectrum Beta-lactamase (ESBL) Produced By Klebsiella Pneumoniae and Their Chemical Compositions." Journal of Food Science, vol. 76, no. 8, 2011, pp. M538-46.
Orhan IE, Ozcelik B, Kan Y, et al. Inhibitory effects of various essential oils and individual components against extended-spectrum beta-lactamase (ESBL) produced by Klebsiella pneumoniae and their chemical compositions. J Food Sci. 2011;76(8):M538-46.
Orhan, I. E., Ozcelik, B., Kan, Y., & Kartal, M. (2011). Inhibitory effects of various essential oils and individual components against extended-spectrum beta-lactamase (ESBL) produced by Klebsiella pneumoniae and their chemical compositions. Journal of Food Science, 76(8), M538-46. https://doi.org/10.1111/j.1750-3841.2011.02363.x
Orhan IE, et al. Inhibitory Effects of Various Essential Oils and Individual Components Against Extended-spectrum Beta-lactamase (ESBL) Produced By Klebsiella Pneumoniae and Their Chemical Compositions. J Food Sci. 2011;76(8):M538-46. PubMed PMID: 22417594.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibitory effects of various essential oils and individual components against extended-spectrum beta-lactamase (ESBL) produced by Klebsiella pneumoniae and their chemical compositions. AU - Orhan,Ilkay Erdogan, AU - Ozcelik,Berrin, AU - Kan,Yüksel, AU - Kartal,Murat, PY - 2012/3/16/entrez PY - 2012/3/16/pubmed PY - 2012/7/7/medline SP - M538 EP - 46 JF - Journal of food science JO - J Food Sci VL - 76 IS - 8 N2 - In the current study, in vitro inhibitory activity of several essential oils obtained from the cultivated plants, Foeniculum vulgare, Mentha piperita and M. spicata, Ocimum basilicum, Origanum majorana, O. onites, O. vulgare, Satureja cuneifolia, and a number of individual essential oil components of terpene and aromatic types were screened against 10 isolated strains of Klebsiella pneumoniae producing extended-spectrum beta-lactamase (ESBL) enzyme, which makes this microorganism quite resistant against the antibiotics: trimetoprime-sulfametoksazol, sulbactam-ampicilin, clavulonate-amoxicilin, ceftriaxon, cefepime, imipenem, ceftazidime, tobramicine, gentamisine, ofloxacin, and ciprofloksasin. All of the essential oils and the components exerted a remarkable inhibition ranging between 32 and 64 μg/mL against all of these strains as strong as the references (ampicilin and oflaxocin) inhibiting at 32 μg/mL. Besides, chemical compositions of the essential oils were elucidated by gas chromatography-mass spectrometry (GC-MS). The essential oils and the pure components widely found in essential oils screened herein have shown remarkable inhibition against ESBL-producing K. pneumoniae strains, which leads to the suggestion that they may be used as food preservatives for this purpose. Practical Application: The essential oils obtained from Foeniculum vulgare, Mentha piperita and M. spicata, O.cimum basilicum, Origanum majorana, O. onites, O. vulgare, and Satureja cuneifolia as well as common essential oil components have shown notable inhibitory effects against 10 isolated strains of Klebsiella pneumoniae producing extended-spectrum beta-lactamase (ESBL) enzyme and they might be used as food preservative or ingredient. SN - 1750-3841 UR - https://www.unboundmedicine.com/medline/citation/22417594/Inhibitory_effects_of_various_essential_oils_and_individual_components_against_extended_spectrum_beta_lactamase__ESBL__produced_by_Klebsiella_pneumoniae_and_their_chemical_compositions_ L2 - https://doi.org/10.1111/j.1750-3841.2011.02363.x DB - PRIME DP - Unbound Medicine ER -