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Postoperative adjuvant transcatheter arterial chemoembolisation improves survival of intrahepatic cholangiocarcinoma patients with poor prognostic factors: results of a large monocentric series.
Eur J Surg Oncol. 2012 Jul; 38(7):602-10.EJ

Abstract

BACKGROUND

The prognosis of patients with intrahepatic cholangiocarcinoma (ICC) is currently unsatisfactory. The aims of this study were to identify prognostic factors after curative ICC resection, and to evaluate the effects of postoperative transcatheter arterial chemoembolisation (TACE).

METHODS

A retrospective analysis was conducted of 114 ICC patients who underwent curative resection from January 2005 to December 2006. Relationships between survival and clinicopathological factors were evaluated using univariate and multivariate analyses. The benefits of adjuvant TACE were investigated separately.

RESULTS

The cumulative 1-, 3-, and 5-year survival rates were 63%, 26%, and 15%, respectively. Multivariate analysis revealed that tumour size ≥ 5 cm (hazard ratio [HR] 1.875, 95% CI 1.139-3.088, P=0.013) and advanced TNM stage (stage III or IV) (HR 1.681, 95% CI 1.035-2.732, P=0.036) were independently associated with poor prognosis. Fifty-seven patients underwent adjuvant TACE. In patients with poor prognostic factors, TACE improved the survival rate (P<0.001). However, in patients without poor prognostic factors, TACE did not significantly change the survival rate (P=0.724).

CONCLUSIONS

Postoperative adjuvant TACE can prolong survival in ICC patients with tumour size ≥ 5 cm or advanced TNM stage.

Authors+Show Affiliations

The Fifth Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, No. 225 Changhai Road, Shanghai 200438, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22417704

Citation

Wu, Z F., et al. "Postoperative Adjuvant Transcatheter Arterial Chemoembolisation Improves Survival of Intrahepatic Cholangiocarcinoma Patients With Poor Prognostic Factors: Results of a Large Monocentric Series." European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, vol. 38, no. 7, 2012, pp. 602-10.
Wu ZF, Zhang HB, Yang N, et al. Postoperative adjuvant transcatheter arterial chemoembolisation improves survival of intrahepatic cholangiocarcinoma patients with poor prognostic factors: results of a large monocentric series. Eur J Surg Oncol. 2012;38(7):602-10.
Wu, Z. F., Zhang, H. B., Yang, N., Zhao, W. C., Fu, Y., & Yang, G. S. (2012). Postoperative adjuvant transcatheter arterial chemoembolisation improves survival of intrahepatic cholangiocarcinoma patients with poor prognostic factors: results of a large monocentric series. European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 38(7), 602-10. https://doi.org/10.1016/j.ejso.2012.02.185
Wu ZF, et al. Postoperative Adjuvant Transcatheter Arterial Chemoembolisation Improves Survival of Intrahepatic Cholangiocarcinoma Patients With Poor Prognostic Factors: Results of a Large Monocentric Series. Eur J Surg Oncol. 2012;38(7):602-10. PubMed PMID: 22417704.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Postoperative adjuvant transcatheter arterial chemoembolisation improves survival of intrahepatic cholangiocarcinoma patients with poor prognostic factors: results of a large monocentric series. AU - Wu,Z F, AU - Zhang,H B, AU - Yang,N, AU - Zhao,W C, AU - Fu,Y, AU - Yang,G S, Y1 - 2012/03/13/ PY - 2011/11/18/received PY - 2012/01/15/revised PY - 2012/02/27/accepted PY - 2012/3/16/entrez PY - 2012/3/16/pubmed PY - 2012/8/14/medline SP - 602 EP - 10 JF - European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology JO - Eur J Surg Oncol VL - 38 IS - 7 N2 - BACKGROUND: The prognosis of patients with intrahepatic cholangiocarcinoma (ICC) is currently unsatisfactory. The aims of this study were to identify prognostic factors after curative ICC resection, and to evaluate the effects of postoperative transcatheter arterial chemoembolisation (TACE). METHODS: A retrospective analysis was conducted of 114 ICC patients who underwent curative resection from January 2005 to December 2006. Relationships between survival and clinicopathological factors were evaluated using univariate and multivariate analyses. The benefits of adjuvant TACE were investigated separately. RESULTS: The cumulative 1-, 3-, and 5-year survival rates were 63%, 26%, and 15%, respectively. Multivariate analysis revealed that tumour size ≥ 5 cm (hazard ratio [HR] 1.875, 95% CI 1.139-3.088, P=0.013) and advanced TNM stage (stage III or IV) (HR 1.681, 95% CI 1.035-2.732, P=0.036) were independently associated with poor prognosis. Fifty-seven patients underwent adjuvant TACE. In patients with poor prognostic factors, TACE improved the survival rate (P<0.001). However, in patients without poor prognostic factors, TACE did not significantly change the survival rate (P=0.724). CONCLUSIONS: Postoperative adjuvant TACE can prolong survival in ICC patients with tumour size ≥ 5 cm or advanced TNM stage. SN - 1532-2157 UR - https://www.unboundmedicine.com/medline/citation/22417704/Postoperative_adjuvant_transcatheter_arterial_chemoembolisation_improves_survival_of_intrahepatic_cholangiocarcinoma_patients_with_poor_prognostic_factors:_results_of_a_large_monocentric_series_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0748-7983(12)00238-7 DB - PRIME DP - Unbound Medicine ER -