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[Update on meat allergy. α-Gal: a new epitope, a new entity?].

Abstract

The association between the carbohydrate galactose-[alpha]-1,3-galactose (α-Gal) and anaphylaxis was first documented after severe hypersensitivity reactions to cetuximab, a chimeric mouse-human IgG1 monoclonal antibody approved for targeted therapy of carcinomas of colon, as well as of the head and neck region. α-Gal is a ubiquitous glycan moiety expressed on cells and tissue of non-primate mammals. Since this epitope is not expressed in humans, it is very immunogenic for them. α-Gal is located on the Fab portion of cetuximab and thus on the murine part of the chimera. The anaphylactic reactions to the antibody were mediated by IgE specific for α-Gal. Anti-α-Gal-IgE were first detected in sera of patients from the southeastern U.S. and reacted with a wide range of mammalian allergens. The geographic distribution prompted investigations of sensitization routes apart from the ingestion of red meat, such as tick bites und parasitic infections. Anti-α-Gal-IgE seems to be of clinical relevance for allergy to red meat and for the pork-cat syndrome. It is also associated with a novel form of delayed anaphylaxis, which appears more than 3 hours following the ingestion of red meat (beef, pork and lamb), a phenomenon which is still to be elucidated. For most of these patients conventional skin prick tests with commercial reagents proved insufficient for diagnosis.

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  • Publisher Full Text
  • Authors+Show Affiliations

    Klinik für Dermatologie, Allergologie und Venerologie, Universität Lübeck, Lübeck, Deutschland. ujappe@fz-borstel.de

    Source

    MeSH

    Allergens
    Anaphylaxis
    Animals
    Cattle
    Disaccharides
    Female
    Food Hypersensitivity
    Humans
    Hypersensitivity, Delayed
    Male
    Meat

    Pub Type(s)

    English Abstract
    Journal Article

    Language

    ger

    PubMed ID

    22418768

    Citation

    Jappe, U. "[Update On Meat Allergy. α-Gal: a New Epitope, a New Entity?]." Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete, vol. 63, no. 4, 2012, pp. 299-306.
    Jappe U. [Update on meat allergy. α-Gal: a new epitope, a new entity?]. Hautarzt. 2012;63(4):299-306.
    Jappe, U. (2012). [Update on meat allergy. α-Gal: a new epitope, a new entity?]. Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete, 63(4), pp. 299-306. doi:10.1007/s00105-011-2266-y.
    Jappe U. [Update On Meat Allergy. α-Gal: a New Epitope, a New Entity?]. Hautarzt. 2012;63(4):299-306. PubMed PMID: 22418768.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - [Update on meat allergy. α-Gal: a new epitope, a new entity?]. A1 - Jappe,U, PY - 2012/3/16/entrez PY - 2012/3/16/pubmed PY - 2012/8/25/medline SP - 299 EP - 306 JF - Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete JO - Hautarzt VL - 63 IS - 4 N2 - The association between the carbohydrate galactose-[alpha]-1,3-galactose (α-Gal) and anaphylaxis was first documented after severe hypersensitivity reactions to cetuximab, a chimeric mouse-human IgG1 monoclonal antibody approved for targeted therapy of carcinomas of colon, as well as of the head and neck region. α-Gal is a ubiquitous glycan moiety expressed on cells and tissue of non-primate mammals. Since this epitope is not expressed in humans, it is very immunogenic for them. α-Gal is located on the Fab portion of cetuximab and thus on the murine part of the chimera. The anaphylactic reactions to the antibody were mediated by IgE specific for α-Gal. Anti-α-Gal-IgE were first detected in sera of patients from the southeastern U.S. and reacted with a wide range of mammalian allergens. The geographic distribution prompted investigations of sensitization routes apart from the ingestion of red meat, such as tick bites und parasitic infections. Anti-α-Gal-IgE seems to be of clinical relevance for allergy to red meat and for the pork-cat syndrome. It is also associated with a novel form of delayed anaphylaxis, which appears more than 3 hours following the ingestion of red meat (beef, pork and lamb), a phenomenon which is still to be elucidated. For most of these patients conventional skin prick tests with commercial reagents proved insufficient for diagnosis. SN - 1432-1173 UR - https://www.unboundmedicine.com/medline/citation/22418768/[Update_on_meat_allergy__α_Gal:_a_new_epitope_a_new_entity]_ L2 - https://dx.doi.org/10.1007/s00105-011-2266-y DB - PRIME DP - Unbound Medicine ER -