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Botany, traditional uses, phytochemistry and pharmacology of Apocynum venetum L. (Luobuma): A review.
J Ethnopharmacol. 2012 May 07; 141(1):1-8.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Apocynum venetum L. (Apocynaceae, Luobuma) has a long history as a Chinese traditional medicine with uses to calm the liver, soothe the nerves, dissipate heat, and promote diuresis. Recently, Luobuma tea has been commercialized as a sedative and anti-aging supplement that has become increasingly popular in North American and East Asian health food markets.

AIMS OF THE REVIEW

The aim of this review is to provide an up-to-date and comprehensive overview of the botany, chemical constituents, traditional uses, pharmacological activities and safety aspects of Apocynum venetum in order to assess its ethnopharmacological use and to explore its therapeutic potentials and future opportunities for research.

BACKGROUND AND METHODS

The accessible literature on Apocynum venetum written in English, Chinese and Japanese were collected and analyzed. The literatures included ancient Chinese herbal classics, pharmacopoeias and articles that included in Pubmed, Web of Science, Google Scholar and Wanfang.

KEY FINDINGS

Modern pharmacological studies demonstrated that Apocynum venetum possess wide pharmacological activities that include antihypertensive, cardiotonic, hepatoprotective, antioxidant, lipid-lowering, antidepressant and anxiolytic effects, which can be explained by the presence of various flavonoid compounds in this plant. The traditional (Lop Nor region) use of Apocynum venetum with tobacco as an agent to detoxify nicotine may receive interest as a possible therapeutic option to detoxify the body from smoking. Based on animal studies and clinical trials, Apocynum venetum causes no severe side effects, even in a stable daily dosage (50mg/person/day) for more than three years.

CONCLUSIONS

Apocynum venetum potentially has therapeutic potential in the prevention and treatment for the cardiovascular and neurological diseases, especially for high blood pressure, high cholesterol, neurasthenia, depression and anxiety. Further investigations are needed to explore individual bioactive compounds responsible for these in vitro and in vivo pharmacological effects and the mode of actions. Further safety assessments and clinical trials should be performed before it can be integrated into medicinal practices.

Authors+Show Affiliations

College of Veterinary Medicine, Northwest A&F University, Yangling 712100, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22421379

Citation

Xie, Wenyan, et al. "Botany, Traditional Uses, Phytochemistry and Pharmacology of Apocynum Venetum L. (Luobuma): a Review." Journal of Ethnopharmacology, vol. 141, no. 1, 2012, pp. 1-8.
Xie W, Zhang X, Wang T, et al. Botany, traditional uses, phytochemistry and pharmacology of Apocynum venetum L. (Luobuma): A review. J Ethnopharmacol. 2012;141(1):1-8.
Xie, W., Zhang, X., Wang, T., & Hu, J. (2012). Botany, traditional uses, phytochemistry and pharmacology of Apocynum venetum L. (Luobuma): A review. Journal of Ethnopharmacology, 141(1), 1-8. https://doi.org/10.1016/j.jep.2012.02.003
Xie W, et al. Botany, Traditional Uses, Phytochemistry and Pharmacology of Apocynum Venetum L. (Luobuma): a Review. J Ethnopharmacol. 2012 May 7;141(1):1-8. PubMed PMID: 22421379.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Botany, traditional uses, phytochemistry and pharmacology of Apocynum venetum L. (Luobuma): A review. AU - Xie,Wenyan, AU - Zhang,Xiaoying, AU - Wang,Tian, AU - Hu,Jianjun, Y1 - 2012/03/06/ PY - 2011/10/20/received PY - 2012/02/02/revised PY - 2012/02/02/accepted PY - 2012/3/17/entrez PY - 2012/3/17/pubmed PY - 2012/8/11/medline SP - 1 EP - 8 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 141 IS - 1 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Apocynum venetum L. (Apocynaceae, Luobuma) has a long history as a Chinese traditional medicine with uses to calm the liver, soothe the nerves, dissipate heat, and promote diuresis. Recently, Luobuma tea has been commercialized as a sedative and anti-aging supplement that has become increasingly popular in North American and East Asian health food markets. AIMS OF THE REVIEW: The aim of this review is to provide an up-to-date and comprehensive overview of the botany, chemical constituents, traditional uses, pharmacological activities and safety aspects of Apocynum venetum in order to assess its ethnopharmacological use and to explore its therapeutic potentials and future opportunities for research. BACKGROUND AND METHODS: The accessible literature on Apocynum venetum written in English, Chinese and Japanese were collected and analyzed. The literatures included ancient Chinese herbal classics, pharmacopoeias and articles that included in Pubmed, Web of Science, Google Scholar and Wanfang. KEY FINDINGS: Modern pharmacological studies demonstrated that Apocynum venetum possess wide pharmacological activities that include antihypertensive, cardiotonic, hepatoprotective, antioxidant, lipid-lowering, antidepressant and anxiolytic effects, which can be explained by the presence of various flavonoid compounds in this plant. The traditional (Lop Nor region) use of Apocynum venetum with tobacco as an agent to detoxify nicotine may receive interest as a possible therapeutic option to detoxify the body from smoking. Based on animal studies and clinical trials, Apocynum venetum causes no severe side effects, even in a stable daily dosage (50mg/person/day) for more than three years. CONCLUSIONS: Apocynum venetum potentially has therapeutic potential in the prevention and treatment for the cardiovascular and neurological diseases, especially for high blood pressure, high cholesterol, neurasthenia, depression and anxiety. Further investigations are needed to explore individual bioactive compounds responsible for these in vitro and in vivo pharmacological effects and the mode of actions. Further safety assessments and clinical trials should be performed before it can be integrated into medicinal practices. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/22421379/Botany_traditional_uses_phytochemistry_and_pharmacology_of_Apocynum_venetum_L___Luobuma_:_A_review_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(12)00071-2 DB - PRIME DP - Unbound Medicine ER -