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Neonatal outcomes are associated with latency after preterm premature rupture of membranes.
J Perinatol. 2012 Dec; 32(12):970-7.JP

Abstract

OBJECTIVE

To determine factors associated with latency time to birth after preterm premature rupture of membranes (PPROM) and the impact on neonatal outcomes.

STUDY DESIGN

Data on singleton pregnancies with PPROM (n=1535 infants) were prospectively collected in a computerized perinatal/neonatal database at a tertiary care perinatal center. Latency was characterized as ≤72h versus >72 h after PPROM.

RESULT

The percentage of women with latency to birth >72 h decreased from 67% in very preterm (gestational age (GA) 25 to 28 weeks) to 10% in late preterm women (GA 33 to 36 weeks). PPROM women with latency ≤72 h were more likely to have pregnancy-induced hypertension and birth weight <3%; PPROM women with latency >72 h were more likely to have received steroids and develop clinical chorioamnionitis. PPROM <32 weeks GA with latency ≤72 h was associated with a two-fold higher incidence of severe neonatal morbidity, while PPROM between 29 to 34 weeks GA and latency ≤72 h was associated with a higher incidence of moderate neonatal morbidity.

CONCLUSION

A latency period >72 h was associated with a decreased incidence of adverse neonatal outcomes up to 32 weeks GA for severe and 34 weeks GA for moderate morbidity indices.

Authors+Show Affiliations

Department of Obstetrics and Gynaecology, Children Health Research Institute, University of Western Ontario, London, ON, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22422118

Citation

Nayot, D, et al. "Neonatal Outcomes Are Associated With Latency After Preterm Premature Rupture of Membranes." Journal of Perinatology : Official Journal of the California Perinatal Association, vol. 32, no. 12, 2012, pp. 970-7.
Nayot D, Penava D, Da Silva O, et al. Neonatal outcomes are associated with latency after preterm premature rupture of membranes. J Perinatol. 2012;32(12):970-7.
Nayot, D., Penava, D., Da Silva, O., Richardson, B. S., & de Vrijer, B. (2012). Neonatal outcomes are associated with latency after preterm premature rupture of membranes. Journal of Perinatology : Official Journal of the California Perinatal Association, 32(12), 970-7. https://doi.org/10.1038/jp.2012.15
Nayot D, et al. Neonatal Outcomes Are Associated With Latency After Preterm Premature Rupture of Membranes. J Perinatol. 2012;32(12):970-7. PubMed PMID: 22422118.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neonatal outcomes are associated with latency after preterm premature rupture of membranes. AU - Nayot,D, AU - Penava,D, AU - Da Silva,O, AU - Richardson,B S, AU - de Vrijer,B, Y1 - 2012/03/15/ PY - 2012/3/17/entrez PY - 2012/3/17/pubmed PY - 2013/6/5/medline SP - 970 EP - 7 JF - Journal of perinatology : official journal of the California Perinatal Association JO - J Perinatol VL - 32 IS - 12 N2 - OBJECTIVE: To determine factors associated with latency time to birth after preterm premature rupture of membranes (PPROM) and the impact on neonatal outcomes. STUDY DESIGN: Data on singleton pregnancies with PPROM (n=1535 infants) were prospectively collected in a computerized perinatal/neonatal database at a tertiary care perinatal center. Latency was characterized as ≤72h versus >72 h after PPROM. RESULT: The percentage of women with latency to birth >72 h decreased from 67% in very preterm (gestational age (GA) 25 to 28 weeks) to 10% in late preterm women (GA 33 to 36 weeks). PPROM women with latency ≤72 h were more likely to have pregnancy-induced hypertension and birth weight <3%; PPROM women with latency >72 h were more likely to have received steroids and develop clinical chorioamnionitis. PPROM <32 weeks GA with latency ≤72 h was associated with a two-fold higher incidence of severe neonatal morbidity, while PPROM between 29 to 34 weeks GA and latency ≤72 h was associated with a higher incidence of moderate neonatal morbidity. CONCLUSION: A latency period >72 h was associated with a decreased incidence of adverse neonatal outcomes up to 32 weeks GA for severe and 34 weeks GA for moderate morbidity indices. SN - 1476-5543 UR - https://www.unboundmedicine.com/medline/citation/22422118/Neonatal_outcomes_are_associated_with_latency_after_preterm_premature_rupture_of_membranes_ L2 - https://doi.org/10.1038/jp.2012.15 DB - PRIME DP - Unbound Medicine ER -