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IgG responses to the gSG6-P1 salivary peptide for evaluating human exposure to Anopheles bites in urban areas of Dakar region, Sénégal.
Malar J. 2012 Mar 16; 11:72.MJ

Abstract

BACKGROUND

Urban malaria can be a serious public health problem in Africa. Human-landing catches of mosquitoes, a standard entomological method to assess human exposure to malaria vector bites, can lack sensitivity in areas where exposure is low. A simple and highly sensitive tool could be a complementary indicator for evaluating malaria exposure in such epidemiological contexts. The human antibody response to the specific Anopheles gSG6-P1 salivary peptide have been described as an adequate tool biomarker for a reliable assessment of human exposure level to Anopheles bites. The aim of this study was to use this biomarker to evaluate the human exposure to Anopheles mosquito bites in urban settings of Dakar (Senegal), one of the largest cities in West Africa, where Anopheles biting rates and malaria transmission are supposed to be low.

METHODS

One cross-sectional study concerning 1,010 (505 households) children (n = 505) and adults (n = 505) living in 16 districts of downtown Dakar and its suburbs was performed from October to December 2008. The IgG responses to gSG6-P1 peptide have been assessed and compared to entomological data obtained in or near the same district.

RESULTS

Considerable individual variations in anti-gSG6-P1 IgG levels were observed between and within districts. In spite of this individual heterogeneity, the median level of specific IgG and the percentage of immune responders differed significantly between districts. A positive and significant association was observed between the exposure levels to Anopheles gambiae bites, estimated by classical entomological methods, and the median IgG levels or the percentage of immune responders measuring the contact between human populations and Anopheles mosquitoes. Interestingly, immunological parameters seemed to better discriminate the exposure level to Anopheles bites between different exposure groups of districts.

CONCLUSIONS

Specific human IgG responses to gSG6-P1 peptide biomarker represent, at the population and individual levels, a credible new alternative tool to assess accurately the heterogeneity of exposure level to Anopheles bites and malaria risk in low urban transmission areas. The development of such biomarker tool would be particularly relevant for mapping and monitoring malaria risk and for measuring the efficiency of vector control strategies in these specific settings.

Authors+Show Affiliations

Unité Mixte de Recherche MIVEGEC (IRD 224-CNRS 5290-UM1), Institut de Recherche pour le Développement, 34394, Montpellier Cedex 8, France. papa-makhtar.drame@ird.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22424570

Citation

Drame, Papa M., et al. "IgG Responses to the gSG6-P1 Salivary Peptide for Evaluating Human Exposure to Anopheles Bites in Urban Areas of Dakar Region, Sénégal." Malaria Journal, vol. 11, 2012, p. 72.
Drame PM, Machault V, Diallo A, et al. IgG responses to the gSG6-P1 salivary peptide for evaluating human exposure to Anopheles bites in urban areas of Dakar region, Sénégal. Malar J. 2012;11:72.
Drame, P. M., Machault, V., Diallo, A., Cornélie, S., Poinsignon, A., Lalou, R., Sembène, M., Dos Santos, S., Rogier, C., Pagès, F., Le Hesran, J. Y., & Remoué, F. (2012). IgG responses to the gSG6-P1 salivary peptide for evaluating human exposure to Anopheles bites in urban areas of Dakar region, Sénégal. Malaria Journal, 11, 72. https://doi.org/10.1186/1475-2875-11-72
Drame PM, et al. IgG Responses to the gSG6-P1 Salivary Peptide for Evaluating Human Exposure to Anopheles Bites in Urban Areas of Dakar Region, Sénégal. Malar J. 2012 Mar 16;11:72. PubMed PMID: 22424570.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - IgG responses to the gSG6-P1 salivary peptide for evaluating human exposure to Anopheles bites in urban areas of Dakar region, Sénégal. AU - Drame,Papa M, AU - Machault,Vanessa, AU - Diallo,Abdoulaye, AU - Cornélie,Sylvie, AU - Poinsignon,Anne, AU - Lalou,Richard, AU - Sembène,Mbacké, AU - Dos Santos,Stéphanie, AU - Rogier,Christophe, AU - Pagès,Frédéric, AU - Le Hesran,Jean-Yves, AU - Remoué,Franck, Y1 - 2012/03/16/ PY - 2012/01/02/received PY - 2012/03/16/accepted PY - 2012/3/20/entrez PY - 2012/3/20/pubmed PY - 2012/7/13/medline SP - 72 EP - 72 JF - Malaria journal JO - Malar J VL - 11 N2 - BACKGROUND: Urban malaria can be a serious public health problem in Africa. Human-landing catches of mosquitoes, a standard entomological method to assess human exposure to malaria vector bites, can lack sensitivity in areas where exposure is low. A simple and highly sensitive tool could be a complementary indicator for evaluating malaria exposure in such epidemiological contexts. The human antibody response to the specific Anopheles gSG6-P1 salivary peptide have been described as an adequate tool biomarker for a reliable assessment of human exposure level to Anopheles bites. The aim of this study was to use this biomarker to evaluate the human exposure to Anopheles mosquito bites in urban settings of Dakar (Senegal), one of the largest cities in West Africa, where Anopheles biting rates and malaria transmission are supposed to be low. METHODS: One cross-sectional study concerning 1,010 (505 households) children (n = 505) and adults (n = 505) living in 16 districts of downtown Dakar and its suburbs was performed from October to December 2008. The IgG responses to gSG6-P1 peptide have been assessed and compared to entomological data obtained in or near the same district. RESULTS: Considerable individual variations in anti-gSG6-P1 IgG levels were observed between and within districts. In spite of this individual heterogeneity, the median level of specific IgG and the percentage of immune responders differed significantly between districts. A positive and significant association was observed between the exposure levels to Anopheles gambiae bites, estimated by classical entomological methods, and the median IgG levels or the percentage of immune responders measuring the contact between human populations and Anopheles mosquitoes. Interestingly, immunological parameters seemed to better discriminate the exposure level to Anopheles bites between different exposure groups of districts. CONCLUSIONS: Specific human IgG responses to gSG6-P1 peptide biomarker represent, at the population and individual levels, a credible new alternative tool to assess accurately the heterogeneity of exposure level to Anopheles bites and malaria risk in low urban transmission areas. The development of such biomarker tool would be particularly relevant for mapping and monitoring malaria risk and for measuring the efficiency of vector control strategies in these specific settings. SN - 1475-2875 UR - https://www.unboundmedicine.com/medline/citation/22424570/IgG_responses_to_the_gSG6_P1_salivary_peptide_for_evaluating_human_exposure_to_Anopheles_bites_in_urban_areas_of_Dakar_region_Sénégal_ L2 - https://malariajournal.biomedcentral.com/articles/10.1186/1475-2875-11-72 DB - PRIME DP - Unbound Medicine ER -