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Abnormal functional connectivity between the anterior cingulate and the default mode network in drug-naïve boys with attention deficit hyperactivity disorder.
Psychiatry Res. 2012 Feb 28; 201(2):120-7.PR

Abstract

A previous study indicated that adults with attention deficit hyperactivity disorder (ADHD) had a decreased anti-correlation between the dorsal anterior cingulate cortex (dACC) and the default mode network (DMN). In this study, we investigated whether children with ADHD also show a decreased anti-correlation between the dACC and the DMN. We also explored the developmental characteristics of the resting-state functional connectivity (RSFC) of the dACC with the DMN in children with ADHD. Resting-state functional magnetic resonance imaging scans were obtained from a 3T scanner in 19 drug-naïve boys with ADHD and 23 controls. Compared with normal controls, the dACC in boys with ADHD showed a significantly decreased negative RSFC with the DMN, including the dorsomedial prefrontal cortex and the posterior cingulate cortex. The RSFC strength between the dACC and the posterior cingulate cortex showed a significantly negative correlation with age in normal controls, but not in boys with ADHD. This decreased anti-correlation may suggest an abnormal balance or interaction between attentional and intrinsic thoughts. Our age-related analysis suggested an abnormal development pattern of the dACC-DMN interaction in ADHD.

Authors+Show Affiliations

Institute of Mental Health, Peking University, Beijing 100191, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22424873

Citation

Sun, Li, et al. "Abnormal Functional Connectivity Between the Anterior Cingulate and the Default Mode Network in Drug-naïve Boys With Attention Deficit Hyperactivity Disorder." Psychiatry Research, vol. 201, no. 2, 2012, pp. 120-7.
Sun L, Cao Q, Long X, et al. Abnormal functional connectivity between the anterior cingulate and the default mode network in drug-naïve boys with attention deficit hyperactivity disorder. Psychiatry Res. 2012;201(2):120-7.
Sun, L., Cao, Q., Long, X., Sui, M., Cao, X., Zhu, C., Zuo, X., An, L., Song, Y., Zang, Y., & Wang, Y. (2012). Abnormal functional connectivity between the anterior cingulate and the default mode network in drug-naïve boys with attention deficit hyperactivity disorder. Psychiatry Research, 201(2), 120-7. https://doi.org/10.1016/j.pscychresns.2011.07.001
Sun L, et al. Abnormal Functional Connectivity Between the Anterior Cingulate and the Default Mode Network in Drug-naïve Boys With Attention Deficit Hyperactivity Disorder. Psychiatry Res. 2012 Feb 28;201(2):120-7. PubMed PMID: 22424873.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abnormal functional connectivity between the anterior cingulate and the default mode network in drug-naïve boys with attention deficit hyperactivity disorder. AU - Sun,Li, AU - Cao,Qingjiu, AU - Long,Xiangyu, AU - Sui,Manqiu, AU - Cao,Xiaohua, AU - Zhu,Chaozhe, AU - Zuo,Xinian, AU - An,Li, AU - Song,Yan, AU - Zang,Yufeng, AU - Wang,Yufeng, Y1 - 2012/03/15/ PY - 2010/05/04/received PY - 2011/06/29/revised PY - 2011/07/01/accepted PY - 2012/3/20/entrez PY - 2012/3/20/pubmed PY - 2012/6/7/medline SP - 120 EP - 7 JF - Psychiatry research JO - Psychiatry Res VL - 201 IS - 2 N2 - A previous study indicated that adults with attention deficit hyperactivity disorder (ADHD) had a decreased anti-correlation between the dorsal anterior cingulate cortex (dACC) and the default mode network (DMN). In this study, we investigated whether children with ADHD also show a decreased anti-correlation between the dACC and the DMN. We also explored the developmental characteristics of the resting-state functional connectivity (RSFC) of the dACC with the DMN in children with ADHD. Resting-state functional magnetic resonance imaging scans were obtained from a 3T scanner in 19 drug-naïve boys with ADHD and 23 controls. Compared with normal controls, the dACC in boys with ADHD showed a significantly decreased negative RSFC with the DMN, including the dorsomedial prefrontal cortex and the posterior cingulate cortex. The RSFC strength between the dACC and the posterior cingulate cortex showed a significantly negative correlation with age in normal controls, but not in boys with ADHD. This decreased anti-correlation may suggest an abnormal balance or interaction between attentional and intrinsic thoughts. Our age-related analysis suggested an abnormal development pattern of the dACC-DMN interaction in ADHD. SN - 0165-1781 UR - https://www.unboundmedicine.com/medline/citation/22424873/Abnormal_functional_connectivity_between_the_anterior_cingulate_and_the_default_mode_network_in_drug_naïve_boys_with_attention_deficit_hyperactivity_disorder_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0925-4927(11)00241-1 DB - PRIME DP - Unbound Medicine ER -