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Differential expression of Immunoglobulin A in the adenoids of children with and without exudative otitis media.
Int J Pediatr Otorhinolaryngol. 2012 May; 76(5):728-30.IJ

Abstract

OBJECTIVE

To evaluate the variation of Immunoglobulin A (IgA) levels in the adenoids of children with otitis media with effusion (OME) and the correlation to age.

METHODS

A total of 129 children were enrolled in this study, including 60 children with OME and 69 children without OME. The children were divided into two groups according to age: aged ≤ 4 years (33 children with OME and 39 children without OME) and aged > 4 years (27 children with OME and 30 children without OME). The samples were collected from hypertrophic adenoids, which could cause obstructive symptoms and/or OME. The IgA concentrations were analyzed by immunohistochemistry in the two groups.

RESULTS

The expression of IgA in the adenoids of children ≤ 4 years was significantly lower than in those aged > 4 years. Among children > 4 years, lower levels of IgA in the adenoids were observed in patients with OME than in patients without OME. However, no statistically significant differences in the IgA levels were found between patients aged ≤ 4 years with and without OME.

CONCLUSIONS

The differential expression of IgA in the adenoids between patients with and without OME was correlated to age.

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Authors+Show Affiliations

Wang B
Department of Otolaryngology, Children's Hospital of Chongqing Medical University, Chongqing, China.
Tang X
No affiliation info available
Xu J
No affiliation info available
Yao H
No affiliation info available

MeSH

AdenoidsAge FactorsCase-Control StudiesChildChild, PreschoolFemaleHumansImmunoglobulin AImmunohistochemistryInfantMaleOtitis Media with EffusionReference Values

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22425064

Citation

Wang, Bing, et al. "Differential Expression of Immunoglobulin a in the Adenoids of Children With and Without Exudative Otitis Media." International Journal of Pediatric Otorhinolaryngology, vol. 76, no. 5, 2012, pp. 728-30.
Wang B, Tang X, Xu J, et al. Differential expression of Immunoglobulin A in the adenoids of children with and without exudative otitis media. Int J Pediatr Otorhinolaryngol. 2012;76(5):728-30.
Wang, B., Tang, X., Xu, J., & Yao, H. (2012). Differential expression of Immunoglobulin A in the adenoids of children with and without exudative otitis media. International Journal of Pediatric Otorhinolaryngology, 76(5), 728-30. https://doi.org/10.1016/j.ijporl.2012.02.036
Wang B, et al. Differential Expression of Immunoglobulin a in the Adenoids of Children With and Without Exudative Otitis Media. Int J Pediatr Otorhinolaryngol. 2012;76(5):728-30. PubMed PMID: 22425064.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential expression of Immunoglobulin A in the adenoids of children with and without exudative otitis media. AU - Wang,Bing, AU - Tang,Xinye, AU - Xu,Jie, AU - Yao,Hongbing, Y1 - 2012/03/16/ PY - 2011/11/29/received PY - 2012/02/08/revised PY - 2012/02/11/accepted PY - 2012/3/20/entrez PY - 2012/3/20/pubmed PY - 2013/4/25/medline SP - 728 EP - 30 JF - International journal of pediatric otorhinolaryngology JO - Int J Pediatr Otorhinolaryngol VL - 76 IS - 5 N2 - OBJECTIVE: To evaluate the variation of Immunoglobulin A (IgA) levels in the adenoids of children with otitis media with effusion (OME) and the correlation to age. METHODS: A total of 129 children were enrolled in this study, including 60 children with OME and 69 children without OME. The children were divided into two groups according to age: aged ≤ 4 years (33 children with OME and 39 children without OME) and aged > 4 years (27 children with OME and 30 children without OME). The samples were collected from hypertrophic adenoids, which could cause obstructive symptoms and/or OME. The IgA concentrations were analyzed by immunohistochemistry in the two groups. RESULTS: The expression of IgA in the adenoids of children ≤ 4 years was significantly lower than in those aged > 4 years. Among children > 4 years, lower levels of IgA in the adenoids were observed in patients with OME than in patients without OME. However, no statistically significant differences in the IgA levels were found between patients aged ≤ 4 years with and without OME. CONCLUSIONS: The differential expression of IgA in the adenoids between patients with and without OME was correlated to age. SN - 1872-8464 UR - https://www.unboundmedicine.com/medline/citation/22425064/Differential_expression_of_Immunoglobulin_A_in_the_adenoids_of_children_with_and_without_exudative_otitis_media_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-5876(12)00129-2 DB - PRIME DP - Unbound Medicine ER -