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PET follow-up in a case of anti-NMDAR encephalitis: arguments for cingulate limbic encephalitis.
Epileptic Disord. 2012 Mar; 14(1):90-3.ED

Abstract

BACKGROUND

The lack of specific MRI abnormalities in anti-NMDA receptor encephalitis makes the identification of the most affected areas difficult. Functional neuroimaging could be useful to identify brain dysfunction associated with psychiatric symptoms, but few precise data are available up to now.

CASE STUDY

A 27-year-old woman was referred for recent behavioural changes and jerks of the right foot. Serial left fronto-temporal seizures were recorded. Identification of anti-NMDA receptor antibodies in CSF indicated a diagnosis of anti-NMDA receptor encephalitis. Two foci of hypermetabolism, in the left prefrontal cortex and the anterior cingulate cortex, were identified using 18-fluorodeoxyglucose PET and both disappeared after treatment. Brain MRI was normal, except for a mild left prefrontal hypersignal.

CONCLUSIONS

The increase in marker uptake in motor and premotor regions in our case probably corresponds to epileptic activity. Our data suggest that the anterior cingulate cortex could play an important role in psychiatric symptoms. Other studies are needed to better understand the pathophysiology of anti-NMDA receptor encephalitis.

Authors+Show Affiliations

Département de Neurologie, CHRU de Strasbourg, France. jean-baptiste.chanson@chrustrasbourg.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

22426441

Citation

Chanson, Jean-Baptiste, et al. "PET Follow-up in a Case of anti-NMDAR Encephalitis: Arguments for Cingulate Limbic Encephalitis." Epileptic Disorders : International Epilepsy Journal With Videotape, vol. 14, no. 1, 2012, pp. 90-3.
Chanson JB, Diaconu M, Honnorat J, et al. PET follow-up in a case of anti-NMDAR encephalitis: arguments for cingulate limbic encephalitis. Epileptic Disord. 2012;14(1):90-3.
Chanson, J. B., Diaconu, M., Honnorat, J., Martin, T., De Seze, J., Namer, I. J., & Hirsch, E. (2012). PET follow-up in a case of anti-NMDAR encephalitis: arguments for cingulate limbic encephalitis. Epileptic Disorders : International Epilepsy Journal With Videotape, 14(1), 90-3. https://doi.org/10.1684/epd.2012.0486
Chanson JB, et al. PET Follow-up in a Case of anti-NMDAR Encephalitis: Arguments for Cingulate Limbic Encephalitis. Epileptic Disord. 2012;14(1):90-3. PubMed PMID: 22426441.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - PET follow-up in a case of anti-NMDAR encephalitis: arguments for cingulate limbic encephalitis. AU - Chanson,Jean-Baptiste, AU - Diaconu,Mihaela, AU - Honnorat,Jérôme, AU - Martin,Thierry, AU - De Seze,Jérôme, AU - Namer,Izzie-Jacques, AU - Hirsch,Edouard, PY - 2012/3/20/entrez PY - 2012/3/20/pubmed PY - 2012/7/20/medline SP - 90 EP - 3 JF - Epileptic disorders : international epilepsy journal with videotape JO - Epileptic Disord VL - 14 IS - 1 N2 - BACKGROUND: The lack of specific MRI abnormalities in anti-NMDA receptor encephalitis makes the identification of the most affected areas difficult. Functional neuroimaging could be useful to identify brain dysfunction associated with psychiatric symptoms, but few precise data are available up to now. CASE STUDY: A 27-year-old woman was referred for recent behavioural changes and jerks of the right foot. Serial left fronto-temporal seizures were recorded. Identification of anti-NMDA receptor antibodies in CSF indicated a diagnosis of anti-NMDA receptor encephalitis. Two foci of hypermetabolism, in the left prefrontal cortex and the anterior cingulate cortex, were identified using 18-fluorodeoxyglucose PET and both disappeared after treatment. Brain MRI was normal, except for a mild left prefrontal hypersignal. CONCLUSIONS: The increase in marker uptake in motor and premotor regions in our case probably corresponds to epileptic activity. Our data suggest that the anterior cingulate cortex could play an important role in psychiatric symptoms. Other studies are needed to better understand the pathophysiology of anti-NMDA receptor encephalitis. SN - 1294-9361 UR - https://www.unboundmedicine.com/medline/citation/22426441/PET_follow_up_in_a_case_of_anti_NMDAR_encephalitis:_arguments_for_cingulate_limbic_encephalitis_ L2 - http://www.jle.com/medline.md?issn=1294-9361&vol=14&iss=1&page=90 DB - PRIME DP - Unbound Medicine ER -