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Differential expression of coxsackievirus and adenovirus receptor on alveolar epithelial cells between fetal and adult mice determines their different susceptibility to coxsackievirus B infection.
Arch Virol. 2012 Jun; 157(6):1101-11.AV

Abstract

Coxsackievirus B (CVB) can cause aseptic meningitis, myocarditis and respiratory disease, especially in newborn infants. To compare the susceptibility to CVB infection of fetal and adult mice, we prepared primary alveolar epithelial cells (AECs) from lungs of BALB/c mice. In contrast to fetal mouse AECs, those of adults were less susceptible to CVB3 infection, as indicated by decreased cytopathic effects, and reduced levels of viral particles bound at the cell surface. In adult mouse AECs, amplification of the viral genome and virus capsid protein VP1 synthesis were concomitantly reduced. In addition, the cell-surface expression of coxsackievirus and adenovirus receptor (CAR), which plays a key role in the initiation of CVB and pulmonary infection, was downregulated in adult mouse AECs. These findings demonstrate that adult mouse AECs are less susceptible to CVB3 due to decreased CAR levels. Thus, these findings strongly indicate that the level of virus receptors on AECs is one of the crucial determinants for the age-dependence of CVB virulence in the mouse lung.

Authors+Show Affiliations

School of Life Sciences, Northeast Normal University, Changchun, Jilin, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22426860

Citation

Sun, Fang, et al. "Differential Expression of Coxsackievirus and Adenovirus Receptor On Alveolar Epithelial Cells Between Fetal and Adult Mice Determines Their Different Susceptibility to Coxsackievirus B Infection." Archives of Virology, vol. 157, no. 6, 2012, pp. 1101-11.
Sun F, Li Y, Jia T, et al. Differential expression of coxsackievirus and adenovirus receptor on alveolar epithelial cells between fetal and adult mice determines their different susceptibility to coxsackievirus B infection. Arch Virol. 2012;157(6):1101-11.
Sun, F., Li, Y., Jia, T., Ling, Y., Liang, L., Liu, G., Chen, H., & Chen, S. (2012). Differential expression of coxsackievirus and adenovirus receptor on alveolar epithelial cells between fetal and adult mice determines their different susceptibility to coxsackievirus B infection. Archives of Virology, 157(6), 1101-11. https://doi.org/10.1007/s00705-012-1254-6
Sun F, et al. Differential Expression of Coxsackievirus and Adenovirus Receptor On Alveolar Epithelial Cells Between Fetal and Adult Mice Determines Their Different Susceptibility to Coxsackievirus B Infection. Arch Virol. 2012;157(6):1101-11. PubMed PMID: 22426860.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential expression of coxsackievirus and adenovirus receptor on alveolar epithelial cells between fetal and adult mice determines their different susceptibility to coxsackievirus B infection. AU - Sun,Fang, AU - Li,Yuxia, AU - Jia,Tianye, AU - Ling,Yan, AU - Liang,Long, AU - Liu,Gang, AU - Chen,Huipeng, AU - Chen,Shan, Y1 - 2012/03/17/ PY - 2011/11/01/received PY - 2012/01/14/accepted PY - 2012/3/20/entrez PY - 2012/3/20/pubmed PY - 2012/8/4/medline SP - 1101 EP - 11 JF - Archives of virology JO - Arch Virol VL - 157 IS - 6 N2 - Coxsackievirus B (CVB) can cause aseptic meningitis, myocarditis and respiratory disease, especially in newborn infants. To compare the susceptibility to CVB infection of fetal and adult mice, we prepared primary alveolar epithelial cells (AECs) from lungs of BALB/c mice. In contrast to fetal mouse AECs, those of adults were less susceptible to CVB3 infection, as indicated by decreased cytopathic effects, and reduced levels of viral particles bound at the cell surface. In adult mouse AECs, amplification of the viral genome and virus capsid protein VP1 synthesis were concomitantly reduced. In addition, the cell-surface expression of coxsackievirus and adenovirus receptor (CAR), which plays a key role in the initiation of CVB and pulmonary infection, was downregulated in adult mouse AECs. These findings demonstrate that adult mouse AECs are less susceptible to CVB3 due to decreased CAR levels. Thus, these findings strongly indicate that the level of virus receptors on AECs is one of the crucial determinants for the age-dependence of CVB virulence in the mouse lung. SN - 1432-8798 UR - https://www.unboundmedicine.com/medline/citation/22426860/Differential_expression_of_coxsackievirus_and_adenovirus_receptor_on_alveolar_epithelial_cells_between_fetal_and_adult_mice_determines_their_different_susceptibility_to_coxsackievirus_B_infection_ L2 - https://dx.doi.org/10.1007/s00705-012-1254-6 DB - PRIME DP - Unbound Medicine ER -