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BRAF(V600E) mutation in Turkish patients with papillary thyroid cancer: strong correlation with indicators of tumor aggressiveness.
Endocrine. 2012 Oct; 42(2):404-10.E

Abstract

Papillary thyroid cancer (PTC) constitutes more than 90% of the thyroid cancers. MAP kinase/ERK pathway plays an important role in the development of several cancers. BRAF which is a member of Raf-kinase family activates this way. BRAF gene activating mutations lead to neoplastic transformation in thyroid follicle cells. In PTC, this mutation itself is a poor prognostic sign independent of other clinicopathological characteristics. We evaluated BRAF(V600E) mutation and clinical-pathological characteristics in Turkish population with PTC. We assessed 109 patients with PTC (88 female, 21 male). The average age was 38.7 ± 9.9 (17-71). BRAF(V600E) mutation was detected using polymerase chain reaction and fluorescent melting curve analysis. The results show that BRAF(V600E) mutation rate was found in 39.45% of our patients. We observed that BRAF(V600E) mutation was significantly higher in men, in tumors larger than 1 cm in size, and in patients with classical PTC. Moreover, statistically significant correlations of BRAF(V600E) with indicators of tumor aggressiveness such as thyroid capsular invasion, multifocality, lymph node metastasis, and extrathyroidal spread were found. Patient groups below and over the age of 45 did not differ in mutation frequency. Patients with micro-PTC were evaluated separately, it was found that BRAF(V600E) mutation was more frequent in the classic type and that lymph node metastasis rate significantly increased when the mutation was present. We concluded that BRAF(V600E) was correlated with indicators of tumor aggressiveness in our study population. This fact is taken into consideration in treatment and follow-up of our patients with PTC and positive BRAF(V600E) mutation.

Authors+Show Affiliations

Department of Endocrinology, Acibadem Maslak Hospital, Buyukdere Cad. No: 40, Maslak, Istanbul, Turkey. neslihandr@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22426956

Citation

Kurtulmus, Neslihan, et al. "BRAF(V600E) Mutation in Turkish Patients With Papillary Thyroid Cancer: Strong Correlation With Indicators of Tumor Aggressiveness." Endocrine, vol. 42, no. 2, 2012, pp. 404-10.
Kurtulmus N, Duren M, Ince U, et al. BRAF(V600E) mutation in Turkish patients with papillary thyroid cancer: strong correlation with indicators of tumor aggressiveness. Endocrine. 2012;42(2):404-10.
Kurtulmus, N., Duren, M., Ince, U., Cengiz Yakicier, M., Peker, O., Aydın, O., Altiok, E., Giray, S., & Azizlerli, H. (2012). BRAF(V600E) mutation in Turkish patients with papillary thyroid cancer: strong correlation with indicators of tumor aggressiveness. Endocrine, 42(2), 404-10.
Kurtulmus N, et al. BRAF(V600E) Mutation in Turkish Patients With Papillary Thyroid Cancer: Strong Correlation With Indicators of Tumor Aggressiveness. Endocrine. 2012;42(2):404-10. PubMed PMID: 22426956.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - BRAF(V600E) mutation in Turkish patients with papillary thyroid cancer: strong correlation with indicators of tumor aggressiveness. AU - Kurtulmus,Neslihan, AU - Duren,Mete, AU - Ince,Umit, AU - Cengiz Yakicier,M, AU - Peker,Onder, AU - Aydın,Ozlem, AU - Altiok,Ender, AU - Giray,Serdar, AU - Azizlerli,Halil, Y1 - 2012/03/17/ PY - 2011/11/01/received PY - 2012/02/29/accepted PY - 2012/3/20/entrez PY - 2012/3/20/pubmed PY - 2013/4/4/medline SP - 404 EP - 10 JF - Endocrine JO - Endocrine VL - 42 IS - 2 N2 - Papillary thyroid cancer (PTC) constitutes more than 90% of the thyroid cancers. MAP kinase/ERK pathway plays an important role in the development of several cancers. BRAF which is a member of Raf-kinase family activates this way. BRAF gene activating mutations lead to neoplastic transformation in thyroid follicle cells. In PTC, this mutation itself is a poor prognostic sign independent of other clinicopathological characteristics. We evaluated BRAF(V600E) mutation and clinical-pathological characteristics in Turkish population with PTC. We assessed 109 patients with PTC (88 female, 21 male). The average age was 38.7 ± 9.9 (17-71). BRAF(V600E) mutation was detected using polymerase chain reaction and fluorescent melting curve analysis. The results show that BRAF(V600E) mutation rate was found in 39.45% of our patients. We observed that BRAF(V600E) mutation was significantly higher in men, in tumors larger than 1 cm in size, and in patients with classical PTC. Moreover, statistically significant correlations of BRAF(V600E) with indicators of tumor aggressiveness such as thyroid capsular invasion, multifocality, lymph node metastasis, and extrathyroidal spread were found. Patient groups below and over the age of 45 did not differ in mutation frequency. Patients with micro-PTC were evaluated separately, it was found that BRAF(V600E) mutation was more frequent in the classic type and that lymph node metastasis rate significantly increased when the mutation was present. We concluded that BRAF(V600E) was correlated with indicators of tumor aggressiveness in our study population. This fact is taken into consideration in treatment and follow-up of our patients with PTC and positive BRAF(V600E) mutation. SN - 1559-0100 UR - https://www.unboundmedicine.com/medline/citation/22426956/BRAF_V600E__mutation_in_Turkish_patients_with_papillary_thyroid_cancer:_strong_correlation_with_indicators_of_tumor_aggressiveness_ L2 - https://dx.doi.org/10.1007/s12020-012-9651-x DB - PRIME DP - Unbound Medicine ER -