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Measurement of macular pigment optical density in a healthy Chinese population sample.
Invest Ophthalmol Vis Sci. 2012 Apr 24; 53(4):2106-11.IO

Abstract

PURPOSE

Macular pigment may protect against age-related macular degeneration (AMD) by its capacity to absorb blue light and scavenge free radicals. Current information on human macular pigment density has been largely from studies on Caucasian populations. The purpose of this study was to assess macular pigment density and its determinant factors in a Chinese population sample.

METHODS

Macular pigment optical density (MPOD) was measured in a healthy Chinese population using heterochromatic flicker photometry (HFP). Participants received a standard ophthalmic examination, and only subjects who were confirmed not to have any eye diseases except mild age-related cataract were included in the study. Demographic and lifestyle data and general health status were recorded by questionnaire.

RESULTS

A total of 281 unrelated healthy Chinese individuals, including 96 males and 185 females, with ages ranging from 17 to 85 years, participated in the study. The mean and standard deviation of MPOD levels were 0.56 ± 0.19, 0.49 ± 0.18, 0.36 ± 0.15, and 0.19 ± 0.12, respectively, at 0.25°, 0.5°, 1.0°, and 1.75° eccentricity points. A significant age-related decline in MPOD was observed at 0.25° (P = 0.014). Females tended to have relatively lower levels of MPOD than males at 0.25° (P = 0.21), 0.5° (P = 0.025), and 1.0° (P = 0.16). No statistically significant association of MPOD was observed with body mass index or smoking status.

CONCLUSIONS

Macular pigment density measured by HFP tended to decline with aging in this healthy Chinese population sample. Females may have lower levels of MPOD than males.

Authors+Show Affiliations

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22427543

Citation

Yu, Jie, et al. "Measurement of Macular Pigment Optical Density in a Healthy Chinese Population Sample." Investigative Ophthalmology & Visual Science, vol. 53, no. 4, 2012, pp. 2106-11.
Yu J, Johnson EJ, Shang F, et al. Measurement of macular pigment optical density in a healthy Chinese population sample. Invest Ophthalmol Vis Sci. 2012;53(4):2106-11.
Yu, J., Johnson, E. J., Shang, F., Lim, A., Zhou, H., Cui, L., Xu, J., Snellingen, T., Liu, X., Wang, N., & Liu, N. (2012). Measurement of macular pigment optical density in a healthy Chinese population sample. Investigative Ophthalmology & Visual Science, 53(4), 2106-11. https://doi.org/10.1167/iovs.11-8518
Yu J, et al. Measurement of Macular Pigment Optical Density in a Healthy Chinese Population Sample. Invest Ophthalmol Vis Sci. 2012 Apr 24;53(4):2106-11. PubMed PMID: 22427543.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Measurement of macular pigment optical density in a healthy Chinese population sample. AU - Yu,Jie, AU - Johnson,Elizabeth J, AU - Shang,Fu, AU - Lim,Apiradee, AU - Zhou,Haiying, AU - Cui,Lei, AU - Xu,Jun, AU - Snellingen,Torkel, AU - Liu,Xipu, AU - Wang,Ningli, AU - Liu,Ningpu, Y1 - 2012/04/24/ PY - 2012/3/20/entrez PY - 2012/3/20/pubmed PY - 2012/6/23/medline SP - 2106 EP - 11 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 53 IS - 4 N2 - PURPOSE: Macular pigment may protect against age-related macular degeneration (AMD) by its capacity to absorb blue light and scavenge free radicals. Current information on human macular pigment density has been largely from studies on Caucasian populations. The purpose of this study was to assess macular pigment density and its determinant factors in a Chinese population sample. METHODS: Macular pigment optical density (MPOD) was measured in a healthy Chinese population using heterochromatic flicker photometry (HFP). Participants received a standard ophthalmic examination, and only subjects who were confirmed not to have any eye diseases except mild age-related cataract were included in the study. Demographic and lifestyle data and general health status were recorded by questionnaire. RESULTS: A total of 281 unrelated healthy Chinese individuals, including 96 males and 185 females, with ages ranging from 17 to 85 years, participated in the study. The mean and standard deviation of MPOD levels were 0.56 ± 0.19, 0.49 ± 0.18, 0.36 ± 0.15, and 0.19 ± 0.12, respectively, at 0.25°, 0.5°, 1.0°, and 1.75° eccentricity points. A significant age-related decline in MPOD was observed at 0.25° (P = 0.014). Females tended to have relatively lower levels of MPOD than males at 0.25° (P = 0.21), 0.5° (P = 0.025), and 1.0° (P = 0.16). No statistically significant association of MPOD was observed with body mass index or smoking status. CONCLUSIONS: Macular pigment density measured by HFP tended to decline with aging in this healthy Chinese population sample. Females may have lower levels of MPOD than males. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/22427543/Measurement_of_macular_pigment_optical_density_in_a_healthy_Chinese_population_sample_ L2 - https://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.11-8518 DB - PRIME DP - Unbound Medicine ER -